IndraLab

Statements

USP49 deubiquitinates Histone_H2B. 6 / 6
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"It has been reported that USP49 deubiquitinates histone H2B and regulates co-transcriptional pre-mRNA splicing; interestingly, p53 is also mainly localized to the nucleus."
29748582
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"Silencing Usp49 induces relatively small changes in gene expression, however alterations in H2B ubiquitination levels caused by Usp49 regulate U1A and U2B association with chromatin and binding to nascent pre-mRNA."
25962961
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"Usp49 in complex with RVB1 and SUG1 yeast homologues deubiquitinates H2B, this modification is required for efficient co-transcriptional splicing of a large set of exons."
25962961
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"Here we report the purification of ubiquitin specific peptidase 49 (USP49) as a histone H2B specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons."
23824326
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"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."
23824326
reach
"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."
23824326