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USP49 deubiquitinates MSX1. 5 / 5
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"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."
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"USP49 deubiquitinates PAX9 and MSX1 proteins."
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"However, no deubiquitinating activity was observed for PAX9 and MSX1 proteins in the presence of USP49CA (Fig. 4B, lane 3; 4E, lane 3; Fig. 4C, lane 5; Fig. 4F, lane 5), upon knockdown of USP49 (Fig. 4B, lane 4; 4E, lane 4; Fig. 4C, lane 6; Fig. 4F, lane 6), USP44, a paralog of USP49 [38] (Supplementary Fig. S9A, B, lane 6), indicating that USP49 deubiquitinates PAX9 and MSX1."
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"Importantly, the loss of USP49 promoted the polyubiquitination of PAX9 and MSX1, thereby triggering rapid protein degradation (Fig. 4)."
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"Here, we demonstrated that USP49 with the UCH domain at the C-terminus is necessary for the interaction and deubiquitination of PAX9 and MSX1."
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