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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP49 deubiquitinates gemcitabine. 1 / 1

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"Recent studies show that DUBs play essential roles in proliferation, motility, and chemoresistance of malignant cells through stabilizing critical proteins.5 For example, USP49 deubiquitinates FKBP51, which serves as a scaffold for dephosphorylating Ser473 residue at Akt, and further sensitizes pancreatic cancer cells to gemcitabine."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...