IndraLab

Statements

USP49 is ubiquitinated. 8 / 8
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"Furthermore, we found that reconstitution of USP49 but not USP49 (C262A) into Usp49 -/- MLFs inhibited HSV-1-induced K63-linked ubiquitination of MITA ( xref )."
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"Moreover, ubiquitination of USP49 was dramatically inhibited in USP49 del but not in WT (Fig. xref and Supplementary Fig. xref )."
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"These results indicated that NEK6 has a potential role in the promotion of Fbxo45-mediated ubiquitination and degradation of USP49."
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"Furthermore, Fbxo45 exerted its oncogenic function partly via promotion of USP49 ubiquitination and degradation."
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"Furthermore, deletion of SPRY abrogated the ubiquitination of USP49 compared with the F-box deletion and WT of Fbxo45 in Panc-1 cells and 293 T cells (Fig. xref , Supplementary Fig. xref )."
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"We observed that Fbxo45 could bind to specific degrons of USP49 through its SPRY domain and enhance USP49 ubiquitination, subsequently leading to USP49 protein destruction in a posttranslational manner."
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"Furthermore, our results also demonstrated that Fbxo45 promoted USP49 ubiquitination (Fig. xref and Supplementary Fig. xref )."
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"More importantly, NEK6 strengthened the Fbxo45-mediated ubiquitination of USP49 WT, while NEK6 had no influence on the ubiquitination of USP49 del (Fig. xref and Supplementary Fig. xref )."
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