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USP49 increases the amount of TP53. 2 / 2

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"Importantly, USP49 knockout stimulated MDM2 transcriptional level and then inhibited the mRNA levels of TP53 target genes."

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"Our findings suggest that the USP49/HDAC3 signaling axis up-regulates p53 expression by enhancing H3K18 lactylation, thereby inducing ferroptosis."

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IndraLab

Statements

USP49 increases the amount of TP53. 2 / 2

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