IndraLab

Statements


USP49 deubiquitinates STING1. 3 / 3
1 | 2

"Mechanistically, USP49 removes K63-linked ubiquitin chains from MITA after HSV-1 infection which inhibits the aggregation of MITA and the subsequent recruitment of TBK1 to the signaling complex."

reach
"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."

reach
"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."