IndraLab

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USP49 deubiquitinates STING1. 3 / 3

1 | 2

"Mechanistically, USP49 removes K63-linked ubiquitin chains from MITA after HSV-1 infection which inhibits the aggregation of MITA and the subsequent recruitment of TBK1 to the signaling complex."

30943264

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reach

"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."

35033428

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reach

"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."

30943264

INDRA sources:

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IndraLab

Statements

USP49 deubiquitinates STING1. 3 / 3

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