IndraLab

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USP49 deubiquitinates BAG2. 3 / 3
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"USP49 promotes the proliferation and chemoresistance of CRC cells by deubiquitinating and stabilizing Bcl-2-associated athanogene 2 (BAG2)."
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"20 For instance, USP49 deubiquitinates and stabilizes Bcl‐2‐Associated Athanogene 2 (BAG2) which is a well‐known oncogenic protein that antagonizes apoptosis and enables adaptive response in colorectal cancer."
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"In addition, BAG2 is deubiquitinated and stabilized by USP49, and knockdown of USP49 markedly inhibits colorectal cancer proliferation, colony formation, and chemoresistance resistance in vitro 19."
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