IndraLab

Statements

USP49 inhibits AKT. 3 / 3
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"In contrast, another DUB, USP49, inhibits AKT pathway by promoting interaction of PHLPP1 to AKT, thus facilitating the de-phosphorylation of AKT."
28923280
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"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."
31001918
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"In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling."
31001918