IndraLab

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USP49 leads to the deubiquitination of TP53. 4 / 4
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"USP49 suppresses p53 ubiquitination."
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"To assess this, we co-transfected HA-p53, Myc-ubiquitin, and Flag-USP49 into 293T cells, and found that USP49 suppressed ubiquitination of HA-p53."
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"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."
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"In our study, we identified <span class="match term0">USP49</span> as a novel deubiquitinase (DUB) for <span class="match term1">p53</span> from a library consisting of 80 DUBs and found that <span class="match term0">USP49</span> has a positive effect on <span class="match term1">p53</span> transcriptional activity and protein stability"
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