IndraLab

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USP49 leads to the deubiquitination of TP53. 3 / 3

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"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."

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"USP49 suppresses p53 ubiquitination."

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"To assess this, we co-transfected HA-p53, Myc-ubiquitin, and Flag-USP49 into 293T cells, and found that USP49 suppressed ubiquitination of HA-p53."

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INDRA sources:

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IndraLab

Statements

USP49 leads to the deubiquitination of TP53. 3 / 3

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