IndraLab

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USP49 increases the amount of MSX1. 4 / 4
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"USP49 increases PAX9 and MSX1 protein levels."
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"Transient transfection of both sgRNA and shRNA targeting USP49 significantly decreased the expression of endogenous PAX9 and MSX1 compared to the mock control (Fig. 2C, lanes 2 and 5)."
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"On the other hand, the loss of USP49 reduces the levels of PAX9 and MSX1 proteins, which causes transient retardation of odontogenic differentiation in human dental pulp stem cells and delays the differentiation of human pluripotent stem cells into the neural crest cell lineage."
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"Furthermore, overexpression of USP49 in hDPSCs dose-dependently increased the expression of endogenous PAX9 and MSX1 proteins (Fig. 2D)."
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