IndraLab

Statements

USP49 activates gemcitabine. 3 / 3
| 3
reach
"USP49 directly increases the stability of FKBP51, a scaffolding protein in the interaction between AKT and PHLPP, and thus enhances sensitivity to gemcitabine."
35760282
reach
"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."
28363942
reach
"Luo et al. [XREF_BIBR] found that FKBP51 could promote PHLPP-Akt interaction and following Akt dephosphorylation at ser473, so that USP49 enhanced cellular response to gemcitabine through FKBP51-Akt signaling."
28938696