IndraLab

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USP49 activates cell population proliferation. 19 / 19
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"In sum, these results demonstrate that USP49 enhances malignant proliferation and facilitates CBP resistance of RB cells.3.3 USP49 accelerates xenograft tumor growth and induces CBP resistance in vivo."
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"Therefore, USP49 promotes RB tumor growth and CBP resistance in vivo.3.4 USP49 promotes cell proliferation and CBP resistance in RB cells via autophagy activation."
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"In this study, we verified that IGF2BP3‐dependent m A modification of USP49 promoted aggressive proliferation, inhibited apoptosis, and aggravated CBP resistance in RB by enhancing autophagy via SIRT1 deubiquitination.USP49 has been reported as an oncogene in several cancer types."
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"For instance, USP49 promotes the proliferation, metastasis, chemoresistance, and peritoneal metastasis in gastric cancer cells."
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"20 Furthermore, USP49 is upregulated in adenocarcinoma of the esophagogastric junction and promotes cancer cell proliferation."
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"Overexpression of USP49 promoted cell proliferation, inhibited cell apoptosis, and increased the IC50 value of CBP in RB cells."
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"On the contrary, USP49 knockdown suppressed cell proliferation, increased cell apoptosis, and reduced the IC50 value of CBP in CBP‐resistant RB cells."
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"In this study, ubiquitin-specific peptidase 49 (USP49) was identified as a novel deubiquitinase of YAP1, knockdown of USP49 inhibited the proliferation, metastasis, chemoresistance, and peritoneal metastasis of GC cells."
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"The present study showed that USP49 promotes cell proliferation, invasion, and antiapoptosis, suggesting a role as a tumor promoter in GBM."
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"USP49 silencing decreases cell proliferation, migration, and invasion and enhances GC cell sensitivity to chemotherapy; however, this effect can be reversed by YAP1 overexpression."
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"We show that loss of USP49 in different cancer cell lines impairs proliferation and increases aneuploidy."
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"Specifically, we show that the depletion of USP49 in different cancer cell lines impairs proliferation."
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"As shown in Fig. 1A, USP49 depletion with three independent shRNAs significantly decreased the proliferation rate of all cell lines, an effect which was maintained more than 6 days (Supplementary Fig. S1)."
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"In this study, we revealed an oncogenic role of USP49 and identified a novel molecular mechanism responsible for USP49 mediated cell proliferation and drug resistance in vitro."
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"Indeed, knockdown of USP49 significantly inhibited the cell proliferation ( Fig. 3 A and B); moreover, re-expression of USP49 markedly rescued the cell proliferation ( Fig. 3 C)."
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"The findings from these assays indicated that USP49 overexpression significantly boosted the proliferation of endometrial cancer cells, whereas USP49 knockdown substantially inhibited their proliferation (Fig. 6D-G)."
| PMC
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"Moreover, overexpression of Glutathione PeroXidase 4 (GPX4) reversed the ferroptosis and proliferation inhibition induced by USP49 knockdown."
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"Functional assays revealed that USP49 promoted aggressive proliferation and conferred CBP resistance in RB cells."
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"Furthermore, USP49 overexpression in Y‐79 cells increased cell proliferation and inhibited cell apoptosis, whereas the knockdown of USP49 in Y‐79/CBP cells exerted an opposite effect (Figure 2F–H)."
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