IndraLab

Statements

USP49 inhibits TP53BP1. 3 / 3
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"USP49 overexpression suppressed ubiquitylation of γH2AX and DSB-induced foci formation of 53BP1."
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"Namely, inhibition or deletion of 53BP1 resulted in increased HR ( Chen, 2020; Xie, 2007; Canny, 2018 ), which is consistent with our results showing that over-expression of USP49 suppressed 53BP1 loa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"But once DSBs were generated, 53BP1 loading on chromatin and NHEJ could be promoted by proteasomal degradation of USP49."
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