IndraLab

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USP49 activates Aneuploidy. 2 / 2
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"We show that loss of USP49 in different cancer cell lines impairs proliferation and increases aneuploidy."
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"However, we found that USP49 downregulation caused a significant increase in aneuploidy (Fig. 2B), suggesting that passage through mitosis in the absence of USP49 would lead to chromosome mis-segregation."
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