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FBXO45 ubiquitinates USP49. 5 / 5
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"FBXO28 contributes to the proliferation of PDAC by promoting ubiquitin-mediated degradation of SMARCC2 (Liu et al., 2023a), and FBXO45 facilitates cell proliferation by ubiquitinating USP49 through binding to its SPRY domain (Wu et al., 2022a)."
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"Additionally, NEK6 has been reported to enhance the ubiquitination and degradation of USP49 by FBXO45 in pancreatic cancer cells [ xref ]."
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"Furthermore, our results also demonstrated that Fbxo45 promoted USP49 ubiquitination (Fig. xref and Supplementary Fig. xref )."
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"Fbxo45-induced USP49 ubiquitination and degradation depend on its SPRY domain."
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"Additionally, NEK6 has been reported to enhance the ubiquitination and degradation of USP49 by FBXO45 in pancreatic cancer cells [64]."
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