IndraLab

Statements

USP49 activates TP53. 4 / 4
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"USP49 upregulates p53 protein stability."
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"However, knockdown of USP49 by shRNA reduced the level of p53 protein in HCT116 cells treated with or without Eto."
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"Conversely, overexpression of USP49 suppressed MDM2 gene expression and then promoted TP53 target genes."
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"To explore the mechanism by which USP49 enhances p53 stability and taking into consideration that USP49 is a member of the USP family of deubiquitinating enzymes, we hypothesized that USP49 may have an effect on p53 ubiquitination."
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