IndraLab

Statements

CYLD affects RIPK1
2 1 | 67
CYLD deubiquitinates RIPK1. 10 / 67
1 | 66
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"Deubiquitination of RIP by over-expressed CYLD was abrogated in optineurin knockdown cells."
21408173
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"Then, a tumor suppressor cylindromatosis (CYLD) protein promotes the deubiquitination of RIP1 in either complex I or complex II."
28789335
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"It does this by binding to ubiquitinated RIP (receptor interacting protein) to displace IKBKG (inhibitor of kappaB kinase gamma), and then bringing in cylindromatosis (CYLD) to deubiquitinate RIP and terminate the signaling pathway XREF_BIBR - XREF_BIBR."
25329564
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"In the course of complex II formation, RIP1 deubiquitination by CYLD, a deubiquitinase that cleaves linear- and K63-ubiquitin chains, plays a crucial role."
33815386
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"CYLD can deubiquitinate RIPK1, freeing it to be phosphorylated and complex with RIPK3 (Complex IIb) to form the necrosome [XREF_BIBR - XREF_BIBR]."
25342597
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"RIPK1 ubiquitylation can be restricted by cIAP inhibition or by the deubiquitylase activity of CYLD, which is recruited to the complex-I through the LUBAC binding protein SPATA2 XREF_BIBR - XREF_BIBR."
29449584
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"[XREF_BIBR] CYLD deubiquitination of TRAF6, RIP1, and NF-kappaB-essential modulator (NEMO) leads to inactivation of NF-kappaB signaling."
25025000
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"The suppression of CYLD by overexpression of LEF-1 stimulates sustained ubiquitination of RIPK1, causing the defection of necroptosis and survival of CLL cells."
32764983
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"The deubiquitination of RIPK1 by CYLD is critical for the activation of necroptosis and complex II formation [16]."
31752870
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"It regulates NF-kappaB signaling by facilitating deubiquitination of ubiquitinated RIP by CYLD [7,14]."
23811275
CYLD deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
CYLD phosphorylated on S418 deubiquitinates RIPK1 on K377. 1 / 1
1 |
biopax:reactome
No evidence text available
Modified CYLD leads to the deubiquitination of RIPK1. 1 / 1
| 1
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"As shown in XREF_FIG, CYLD overexpression caused RIP1 deubiquitination, which was exacerbated by selenite treatment."
24577083
CYLD affects TRAF2
1 1 | 19
CYLD deubiquitinates TRAF2. 10 / 18
1 1 | 16
signor
"Cyld also interacts directly with tumour-necrosis factor receptor (tnfr)-associated factor 2 (traf2), an adaptor molecule involved in by members of the family of tnf/nerve growth factor receptors. (articolo-abstract)"
12917691
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"Using an shRNA approach, Brummelkamp et al. showed that CYLD inhibits NF-kappaB signaling by counteracting TRAF2 ubiquitination [XREF_BIBR]."
21119682
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"The steady state association of TRAF2 with MLKL was diminished upon TNF induced necroptosis induction, and this correlated with CYLD dependent deubiquitylation of TRAF2."
27158445
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
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"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
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"Here we described that the adenoviral vector expressing CYLD (Ad/hTERT-CYLD) augmented the cytotoxicity of TRAIL in HCC cells by negatively regulating NF-kappaB activity since CYLD could reverse the ubiquitination of TNF receptor associated factor 2 (TRAF2) and interact with the IkappaB kinasegamma (IKKgamma)."
16627981
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"Contributing to the " death signal ", CYLD deubiquitylates TRAF2 and RIPK1, allowing the formation of the ripoptosome."
| PMC
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"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
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"Because the target of CYLD in the NF-kappaB pathway is known to be deubiquitination of TRAF2, we also confirmed the deubiquitination of TRAF2 by CYLD in ECs."
18245814
ubibrowser
"We conclude that PrP traps CYLD, preventing it from binding and deubiquitinating RIP1 and TRAF2."
28900035
Modified CYLD leads to the deubiquitination of TRAF2. 2 / 2
| 2
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"Indeed, immunoprecipitation analysis showed that overexpression of CYLD induced deubiquitination of TRAF2 in ECs."
18245814
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"Of importance, overexpression of catalytically inactive CYLD did not induce deubiquitination of TRAF2."
18245814
Mutated CYLD leads to the deubiquitination of TRAF2. 1 / 1
| 1
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"When these serines are mutated to alanines, it generates a super-active CYLD mutant that prevents TNF-alpha-stimulated TRAF2 ubiquitination."
19373246
CYLD affects TRAF6
1 1 | 18
CYLD deubiquitinates TRAF6. 10 / 19
1 1 | 17
reach
"CYLD binding to one of its targets, TRAF6, requires the adaptor protein p62, which promotes the deubiquitylation of TRAF6 by CYLD 17 and probably also modulates the DUB activity of CYLD through induction of CYLD ubiquitylation 34."
18535581
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"Conversely, the PB1 domain of p62 also interacts with CYLD, a deubiquitinase, which inhibits TRAF6 polyubiquitination and serves as a negative regulator for RANK mediated NF-kappaB activation and osteoclastogenesis 113."
23856904
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"In support of this notion, in vivo poly-ubiquitination assays demonstrate that depletion of beta-TRCP impaired TRAF6 self ubiquitination likely due to enhancement of TRAF6 deubiquitination by CYLD, concomitant with a reduction in beta-TRCP-dependent ubiquitination of CYLD and impairment of auto-phosphorylation of TRAF6-downstream kinase IKKalpha."
24961988
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"CYLD deubiquitylates TRAF6, which transduces the RANK-mediated signal [99]."
30123285
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"For instance, p62, one adaptor protein, can promote the deubiquitylation of TRAF6 (one of p62 targets) by CYLD."
32850399
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"Here we demonstrated that during the RANKL dependent signaling pathway, CYLD stabilization by depletion of beta-TRCP decreased the ubiquitination of TRAF6 and impaired auto-phosphorylation of the TRAF6-downstream kinase IKKalpha."
24961988
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"OPTN negatively regulates IRAK-1 mediated NF-kappaB activation possibly by facilitating CYLD dependent deubiquitination of TRAF6."
29951055
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"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
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"Previously it has been known that TNF receptor associated factor 6 (TRAF6) acts as an E3 ligase for Akt-K63 polyubiquitination, and CYLD deubiquitinates TRAF6."
22491319
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"CYLD also decreased IFN promotor activation by deubiquitinating TRAF2 and TRAF6 in HEK293 T cells, respectively [29, 30] ."
31208841
Modified CYLD leads to the deubiquitination of TRAF6. 1 / 1
| 1
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"We showed that CYLD over-expression largely inhibited TRAF-6 ubiquitination, a step that is required for its activation."
26056944
CYLD affects IKBKG
3 1 | 10
CYLD deubiquitinates IKBKG. 10 / 11
1 | 10
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"To confirm that Tax- or TRAF6 induced polyubiquitination of NEMO is blocked by CYLD expression, NEMO and an HA tagged ubiquitin mutant (HA-K63Ub) were co-expressed with Tax or TRAF6 in the presence or[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418100
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"When transfected into mammalian cells, CYLD deubiquitinates NEMO as well as several IKK upstream regulators, including TRAF2, TRAF6, TRAF7, RIP1, and Tak1."
19373246
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
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"CYLD deubiquitinates NEMO, thus decreasing its stability and preventing the IKK complex from phosphorylating IkappaB, and NF-kappaB activation."
28295216
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"Deubiquitinating enzyme CYLD inhibits NEMO linear ubiquitination, possibly by disassembling both K63 linked and linear polyubiquitin."
21811235
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
reach
"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
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"CYLD also deubiquitinates IkappaB kinase gamma (IKKgamma, also known as NEMO), the regulatory subunit of IKK thus inhibiting the activation of IKK."
19489724
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"CYLD physically interacts with and deubiquitinates NEMO, thereby negatively regulating NF-kappaB activation [XREF_BIBR]."
18775672
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"CYLD can deubiquitinate NEMO, preventing it from causing phosphorylation of IkB, thereby killing the signal [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25342597
CYLD deubiquitinates IKBKG on K285. 2 / 2
2 |
biopax:pid
No evidence text available
biopax:reactome
No evidence text available
CYLD deubiquitinates IKBKG phosphorylated on S85 on lysine. 1 / 1
1 |
biopax:pid
No evidence text available
12917691
CYLD affects DDX58
3 1 | 9
CYLD deubiquitinates DDX58. 9 / 9
1 | 8
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"CYLD (cylindromatosis) deubiquitinates RIG-I and several downstream molecules to prevent premature RIG-I activation in uninfected cells [17], while USP3 deubiquitinates RIG-I specifically after viral infection, likely serving as a negative feedback regulator [18]."
25644461
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"ORF64, USP25, USP21, USP15, USP3, Cylindromatosis (CYLD), porcine epidemic diarrhea virus papain-like protease 2 (PEDV PLP2) and transmissible gastroenteritis virus papain-like protease1 (TGEV PL1) are the DUBs found to deubiquitinate RIG-I."
31208841
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"CYLD (cylindromatosis) deubiquitinates RIG-I and several downstream molecules to prevent premature RIG-I activation in uninfected cells [XREF_BIBR], while USP3 deubiquitinates RIG-I specifically after viral infection, likely serving as a negative feedback regulator [XREF_BIBR]."
25644461
reach
"Tumor suppressor protein cylindromatosis (CYLD) reduced the baseline Lys63-linked ubiquitination of RIG-I in uninfected cells [69]."
25023063
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"CYLD can inhibit ubiquitination of the RIG1 cytoplasmic viral RNA sensor and also downregulate antiviral Interferon production by controlling IKK activation [XREF_BIBR]."
25342597
ubibrowser
"SDC4 likely promotes redistribution of RIG-I and CYLD in a perinuclear pattern post viral infection, and thus enhances the RIG-I-CYLD interaction and potentiates the K63-linked deubiquitination of RIG-I."
27279133
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"XREF_BIBR, XREF_BIBR We and others have recently shown that RIG-I ubiquitination and TBK1 and IKKepsilon activation are negatively regulated by CYLD, XREF_BIBR, XREF_BIBR a deubiquitinase known to digest K63 linked ubiquitin chains."
21946435
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"CYLD has been shown to deubiquitinate, or prevent ubiquitination of RIG-I in cells."
21135871
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"A simple explanation for this result is that the carboxyl-terminal fragment of SDC4 brings RIG-I and CYLD close together, which promotes the deubiquitination of RIG-I by CYLD."
27279133
CYLD deubiquitinates DDX58 ubiquitinated on K172 and K154 on K164. 1 / 1
1 |
biopax:reactome
No evidence text available
CYLD deubiquitinates DDX58 ubiquitinated on K154 and K164 on K172. 1 / 1
1 |
biopax:reactome
No evidence text available
CYLD deubiquitinates DDX58 ubiquitinated on K172 and K164 on K154. 1 / 1
1 |
biopax:reactome
No evidence text available
Modified CYLD leads to the deubiquitination of DDX58. 1 / 1
| 1
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"Loss of CYLD in DCs causes accumulation of ubiquitination of RIG-I indicating that RIG-I is constantly in the cycle of ubiquitination deubiquitination with deubiquitination being a dominant event in steady state."
18703349
CYLD affects BCL3
1 1 | 11
CYLD deubiquitinates BCL3. 10 / 12
1 1 | 10
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"The CYLD protein deubiquitinates Bcl-3 and inhibits its nuclear translocation, so alterations in these gene or upstream events to it present an additional layer of regulation."
22195643
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"CYLD is also able to deubiquitinate Bcl-3 and prevent it from entering nucleus, where Bcl-3 can interact with NFkappaB family members (p50 and p52) to activate the transcription of NFkappaB target genes."
19037995
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"In addition to its deubiquitination effects on TRAFs and IKKgamma, CYLD also deubiquitinates Bcl-3, and in so doing prevents its nuclear localization."
18977328
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"CYLD deubiquitinates several NF-kappaB regulators, including TRAF2, TRAF6, and NEMO as well as BCL3, a member of the NF-kappaB family of transcription factors."
19481526
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"CYLD deubiquitylates BCL-3 inhibiting its nuclear translocation and so decreases the transcription of BCL-3 target genes including CCND [XREF_BIBR]."
28900014
ubibrowser
"In this region, CYLD associates with its substrate Bcl-3 and prevents the nuclear localization of Bcl3"
26763122
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"In the present study, the cytoplasmic and perinuclear expression levels of CYLD suggest that CYLD may play a role in the deubiquitination of BCl-3 and/or TRAF in NF-kappaB signaling within the cytoplasm or perinuclear region in keratinocytes of normal skin and cholesteatoma, in agreement with previously reported results."
20414373
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"In these cases, mutated CYLD is unable to deubiquitinate Bcl-3, allowing increased proliferation in cell of the skin adnexa [XREF_BIBR]."
22195643
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"In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-kappaB and activates transcription of proliferation genes in response to growth signals."
16713556
reach
"As for CYLD, studies have shown that CYLD binds to and deubiquitylates BCL-3 inhibiting its nuclear translocation, leading to decreased transcription of CCND, and delayed cells from entering S-phase 35."
33654169
Modified CYLD leads to the deubiquitination of BCL3. 1 / 1
| 1
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"Loss of CYLD expression in melanoma promoted ubiquitination of BCL-3, which is a transcriptional regulator of N-cadherin expression [28]."
22085498
CYLD affects AKT
| 11
CYLD deubiquitinates AKT. 8 / 8
| 8
reach
"Because CYLD suppresses ubiquitination and activation of Akt, it is possible that CYLD may also inhibit cancer cell proliferation and survival."
23300340
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"To determine whether CYLD is a direct DUB for Akt, we performed in vitro deubiquitination assays and found that deubiquitination of Akt was mediated by wild-type CYLD but not the C601A mutant (XREF_FIG)."
23300340
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"Because CYLD is a known deubiquitinase and Akt ubiquitination is critical for its functional activity XREF_BIBR, we next investigated whether CYLD deubiquitinates Akt."
22491319
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"In this study we provided experimental evidences for direct interaction between Akt and CYLD, and also showed that CYLD does directly deubiquitinate Akt under both endogenous and exogenous conditions."
22491319
reach
"Among the DUBs, only CYLD effectively reduced the ubiquitination of Akt (XREF_FIG and XREF_SUPPLEMENTARY)."
23300340
reach
"Both E3 ligases TRAF6 [158] and Skp2 [159] regulate Akt activity through K63 linked ubiquitination while CYLD promotes deubiquitination of Akt [160]."
30217566
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"Reversely, CYLD negatively regulates Akt signaling by deubiquitinating Akt in TGFbeta signaling [XREF_BIBR]."
27119228
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"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
28412322
Mutated CYLD leads to the deubiquitination of AKT. 1 / 1
| 1
reach
"We found that the inhibitory effect of CYLD on ubiquitination of Akt depended on its catalytic activity, because the catalytically dead mutant of CYLD (Cys 601 --> Ala 601; C601A) failed to attenuate ubiquitination of Akt (XREF_FIG)."
23300340
CYLD deubiquitinates AKT ubiquitinated on K63 on K63. 1 / 1
| 1
reach
"CYLD deubiquitinates K63 ubiquitinated Akt to inhibit Smad3."
22491319
Ubiquitinated CYLD leads to the deubiquitination of AKT. 1 / 1
| 1
reach
"We also demonstrated that PI3K activity, which is usually essential for growth factor mediated Akt activation, is dispensable for growth factor mediated ubiquitination and CYLD mediated deubiquitination of Akt."
23300340
CYLD affects TP53
1 | 8
CYLD deubiquitinates TP53. 9 / 9
1 | 8
ubibrowser
"Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress.| Collectively, our results identify CYLD as a deubiquitinase facilitating DNA damage-induced p53 activation and suggest that regulation of p53 responses to genotoxic stress contributes to the tumour suppressor function of CYLD."
27561390
reach
"As shown in XREF_FIG and XREF_SUPPLEMENTARY, in contrast to WT CYLD, the catalytically inactive CYLDR936X (R/X) and CYLDH871N (H/N) mutants did not diminish p53 ubiquitination although they bound p53, demonstrating that CYLD DUB activity is required to reduce p53 ubiquitination."
27561390
reach
"To address this question, we first assessed the capacity of CYLD to reduce p53 ubiquitination in cells overexpressing HA tagged Lys-to-Arg ubiquitin mutants that can only form K48- or K63 linked chains."
27561390
reach
"Furthermore, recombinant His CYLD reduced ubiquitination of Flag-p53 immunoprecipitated from CpT treated HEK293T cells, showing that CYLD can directly deubiquitinate p53 in a cell-free in vitro assay (XREF_SUPPLEMENTARY)."
27561390
reach
"CYLD deubiquitinates p53 facilitating its stabilization."
27561390
reach
"Together, these results suggested that CYLD directly interacts with and deubiquitinates p53 facilitating its optimal stabilization in response to DNA damage."
27561390
reach
"Mechanistically, we show that CYLD interacts with and deubiquitinates p53 in response to DNA damage."
27561390
reach
"This experiment showed that CYLD diminishes p53 ubiquitination in cells expressing HA-mutant ubiquitin forming K63 only chains, but also in cells expressing HA-mutant ubiquitin forming K48 only chains (XREF_FIG)."
27561390
reach
"Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress."
27561390
CYLD affects MAP3K7
1 | 8
CYLD deubiquitinates MAP3K7. 9 / 9
1 | 8
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"Although it is not yet clear precisely how CYLD regulates the function of the CARMA1-BCL-10-MALT1 signalosome, CYLD deubiquitylates TAK1 and thereby suppresses its catalytic activity 19."
18535581
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"These results indicate that USP4 mainly inhibits inducible TAK1 polyubiquitination and activation whereas CYLD mainly inhibits basal level of TAK1 polyubiquitination and activation."
21331078
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"Finally, we showed that CYLD interacts with and deubiquitinates TAK1 to negatively regulate the activation of the downstream MKK3/6-p 38alpha/beta pathway."
18332137
reach
"In this investigation, we found that CYLD failed to inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination and NF-kappaB activation (XREF_FIG, XREF_SUPPLEMENTARY)."
21331078
reach
"CYLD does not inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination."
21331078
ubibrowser
"The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.&CYLD targets a ubiquitin-dependent kinase, transforming growth factor-beta-activated kinase 1 (Tak1), and inhibits its ubiquitination and autoactivation."
22057290
reach
"Indeed, our data suggest that CYLD directly targets Tak1 and inhibits Tak1 ubiquitination."
17548520
reach
"Koga et al. had reported that CYLD interacted with and deubiquitinates TAK1 by negatively regulating the activation of the downstream MKK3/6-p 38alpha/beta pathway to resist the infection of gram positive bacterium Streptococcus pneumonia [XREF_BIBR]."
27738385
reach
"Inclusion of Cyld (WT) (XREF_FIG, lane3) but not Cyld (C601A) mutant (XREF_FIG, lane4) that lacks the DUB activity 37 resulted in diminished Tak1 ubiquitination suggesting that Cyld deubiquitinated Tak1."
22057290
CYLD affects Tax
| 7
CYLD deubiquitinates Tax. 4 / 4
| 4
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"Since CYLD deubiquitinates Tax, we examined the effect of CYLD on these Tax specific signaling events."
21824392
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"Since CYLD is a K63 specific DUB, we examined whether the ubiquitination of Tax is negatively regulated by CYLD."
21824392
reach
"CYLD inhibits Tax ubiquitination."
21824392
reach
"As expected, the wildtype CYLD, but not its catalytically inactive mutant, efficiently inhibited Tax ubiquitination."
21824392
Mutated CYLD deubiquitinates Tax. 3 / 3
| 3
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"Consistently, a phospho-mimetic CYLD mutant fails to inhibit Tax ubiquitination."
21824392
reach
"Importantly, a phospho-mimetic CYLD mutant harboring serine to glutamic acid substitutions at the phosphorylation sites completely failed to deubiquitinate Tax, whereas a mutant harboring serine to analine mutations at the phsphorylation sites of CYLD (CYLD7SA) remained active in Tax deubiquitination."
21824392
reach
"A phospho-mimetic CYLD mutant failed to inhibit Tax ubiquitination."
21824392
CYLD affects NFkappaB
| 7
CYLD deubiquitinates NFkappaB. 7 / 7
| 7
reach
"Deubiquitination of NF-kappaB members by CYLD is crucial in controlling the magnitude and nature of cell activation."
19342479
reach
"CYLD deubiquitinates several NF-kappaB regulators, including TRAF2, TRAF6, and NEMO as well as BCL3, a member of the NF-kappaB family of transcription factors."
19481526
reach
"In vivo, CYLD also reduced hepatic STAT3 K63 ubiquitination and activation, NF-kappaB activation, IL-6 and NOX2 mRNA production as well as fibrin production in murine listeriosis."
23825949
reach
"CYLD deubiquitinates NEMO, thus decreasing its stability and preventing the IKK complex from phosphorylating IkappaB, and NF-kappaB activation."
28295216
reach
"In this investigation, we found that CYLD failed to inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination and NF-kappaB activation (XREF_FIG, XREF_SUPPLEMENTARY)."
21331078
reach
"18 CYLD 's deubiquitination of NFkappaB inhibits NFkappaB activity without decreasing NFkappaB protein expression."
23034333
reach
"Mechanistically, our results reveal that miR-135b directly targets the 3 '-untranslated region (UTR) of the deubiquitinase CYLD, thereby modulating ubiquitination and activation of NF-kappaB signaling."
33990540
CYLD affects NLRP6
| 6
CYLD deubiquitinates NLRP6. 6 / 6
| 6
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"For the regulation of the NLRP6 inflammasome, Mukherjee et al. [107] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld, which mediates deubiquitination of NLRP6; as a consequence, Cyld inhibits NLRP6-ASC assembly and IL-18 production."
33808793
reach
"Cyld deubiquitinated NLRP6, suggesting that Cyld directly deubiquitinates NLRP6 (XREF_FIG)."
32424362
reach
"To confirm that Cyld directly deubiquitinates NLRP6, we coexpressed Flag -- NLRP6 with Ub."
32424362
reach
"Coexpression of Cyld with NLRP6 and UbK63 markedly inhibited ubiquitination of NLRP6 (XREF_FIG, lane 4), suggesting that Cyld cleaves K63 linked Ub chains."
32424362
reach
"NLRP6 ubiquitination was diminished in the presence of wild-type Cyld but not with the Cyld (C601A) deubiquitinase defective mutant, suggesting that Cyld deubiquitinates NLRP6 (XREF_FIG)."
32424362
reach
"Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation."
32424362
CYLD affects TBK1
1 | 4
CYLD leads to the deubiquitination of TBK1. 5 / 5
1 | 4
reach
"CYLD also inhibits the ubiquitylation of TBK1 and IKKɛ, which contributes to the negative regulation of IFN responses ."
28959952
ubibrowser
"CYLD removes polyubiquitin chains from RIG-I as well as from TANK binding kinase 1 (TBK1), the kinase that phosphorylates IRF3, coincident with an inhibition of the IRF3 signalling pathway."
25923723
reach
"In addition, CYLD also inhibits the ubiquitination of TBK1 and IKKepsilon, which also contributes to the negative regulation of IFN responses by CYLD 79."
27012466
reach
"CYLD also inhibits the ubiquitylation of TBK1 and IKKε, which contributes to the negative regulation of IFN responses 171 ."
28959952
reach
"XREF_BIBR, XREF_BIBR We and others have recently shown that RIG-I ubiquitination and TBK1 and IKKepsilon activation are negatively regulated by CYLD, XREF_BIBR, XREF_BIBR a deubiquitinase known to digest K63 linked ubiquitin chains."
21946435
CYLD affects SMAD7
1 | 4
CYLD deubiquitinates SMAD7. 3 / 3
1 | 2
ubibrowser
"This showed that CYLD can bind to SMAD7 and deubiquitinate SMAD7 at Lysine 360 and 374 residues, which are required for the activation of TAK1 and p38 signaling"
24756567
reach
"CYLD deubiquitinates Smad7 and inhibits TGF-β signaling (58)."
30386338
reach
"CYLD deubiquitinates Smad7 and thereby inhibits the activation of TAK1 and p38, thus inhibiting the TGFbeta induced development of regulatory T cells."
22335355
CYLD deubiquitinates SMAD7 on K64. 1 / 1
| 1
reach
"Moreover, CYLD appears to deubiquitylate SMAD7 at Lys360 and Lys374 but not at Lys64 or Lys70 [XREF_BIBR]."
22724073
CYLD deubiquitinates SMAD7 at position 374. 1 / 1
| 1
reach
"Under endogenous conditions, CYLD formed a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues."
21931165
CYLD affects IKK_complex
| 4
CYLD deubiquitinates IKK_complex. 4 / 4
| 4
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"CYLD also deubiquitinates IkappaB kinase gamma (IKKgamma, also known as NEMO), the regulatory subunit of IKK thus inhibiting the activation of IKK."
19489724
reach
"CYLD also inhibits the ubiquitylation of TBK1 and IKKɛ, which contributes to the negative regulation of IFN responses ."
28959952
reach
"When transfected into mammalian cells, CYLD deubiquitinates NEMO as well as several IKK upstream regulators, including TRAF2, TRAF6, TRAF7, RIP1, and Tak1."
19373246
reach
"CYLD also inhibits the ubiquitylation of TBK1 and IKKε, which contributes to the negative regulation of IFN responses 171 ."
28959952
CYLD affects ARHGEF12
1 | 3
CYLD deubiquitinates ARHGEF12. 3 / 3
1 | 2
ubibrowser
"Mechanistically, CYLD does not interact with RhoA; instead, it interacts with and deubiquitinates leukemia-associated RhoGEF (LARG)."
23405219
reach
"In the present study, we show that CYLD deubiquitinates LARG, thus adding LARG to the growing list of CYLD substrates."
23405219
reach
"Taken together, our data provide the first evidence that CYLD deubiquitinates LARG and increases its ability to catalyze the GDP/GTP exchange on RhoA."
23405219
Modified CYLD leads to the deubiquitination of ARHGEF12. 1 / 1
| 1
reach
"Conversely, overexpression of CYLD dramatically inhibited LARG ubiquitination (XREF_FIG)."
23405219
CYLD affects STING1
| 3
CYLD deubiquitinates STING1. 3 / 3
| 3
reach
"Notably, the CYLD USP domain also deubiquitinated STING in vitro (S6D Fig), which is consistent with our observation in S4E Fig. To substantiate this finding, we transfected Flag-STING along with HA-tagged WT ubiquitin or ubiquitin mutants in the presence or absence of CYLD, followed by immunoblotting."
30388174
reach
"Therefore, STING translocated from the ER to the Golgi upon HSV-1 stimulation, and CYLD partially accumulated with STING to promote STING deubiquitination."
30388174
reach
"We also confirmed that human CYLD and murine CYLD deubiquitinated STING in vitro, but the catalytically dead mutants (human CYLD C601S and murine CYLD C597S) could not perform the same function (S6D and S6E Fig)."
30388174
CYLD affects NTRK1
1 | 2
CYLD deubiquitinates NTRK1. 3 / 3
1 | 2
reach
"In the internalization of the nerve growth factor receptor TrkA, siRNA mediated suppression of CYLD causes sustained TrkA ubiquitination with Lys63 chains (Geetha et al., 2005)."
18313383
reach
"Geetha and collaborators saw that the polyubiquitination of TrkA increases when CYLD is depleted, but no direct evidence of TrkA deubiquitination by CYLD was provided [XREF_BIBR]."
28335430
ubibrowser
"Moreover, additional studies showed that CYLD specifically deubiquitinates polyubiquitin chains at K63 of different substrates (e.g., TRAF2 and TRAF6), or tyrosine kinase receptors such as TrkA."
28335430
CYLD affects MIB2
1 | 2
CYLD deubiquitinates MIB2. 3 / 3
1 | 2
reach
"As we demonstrated that MIB2 can ubiquitylate itself as well as CYLD, we postulated that CYLD, as an ubiquitin hydrolase, might deubiquitylate MIB2, hence providing a potential mechanism of mutual regulation."
25565632
ubibrowser
"?To dissect CYLD function we used a proteomics approach to identify CYLD interacting proteins and identified MIB2, an ubiquitin ligase enzyme involved in Notch signalling, as a protein which interacts with CYLD. Coexpression of CYLD and MIB2 resulted in stabilisation of MIB2 protein levels and was associated with reduced levels of JAG2, a ligand implicated in Notch signalling.?"
25565632
reach
"Moreover, MIB2, an E3 ligase for the Notch ligand JAG2, is deubiquitinated and stabilized by CYLD."
27844253
CYLD affects IKBKE
| 3
CYLD leads to the deubiquitination of IKBKE. 3 / 3
| 3
reach
"In addition, CYLD also inhibits the ubiquitination of TBK1 and IKKepsilon, which also contributes to the negative regulation of IFN responses by CYLD 79."
27012466
reach
"We further show that CYLD targets a cytoplasmic RNA sensor, RIG-I, and inhibits the ubiquitination of this IKKepsilon and TBK1 stimulator."
18467330
reach
"XREF_BIBR, XREF_BIBR We and others have recently shown that RIG-I ubiquitination and TBK1 and IKKepsilon activation are negatively regulated by CYLD, XREF_BIBR, XREF_BIBR a deubiquitinase known to digest K63 linked ubiquitin chains."
21946435
CYLD affects DVL
| 3
CYLD leads to the deubiquitination of DVL. 3 / 3
| 3
reach
"Knockout of CYLD in tumor cells can prevent K63 linked deubiquitination of Dvl [Dishevelled], which enhances Wnt and beta-catenin signaling [XREF_BIBR]."
25342597
reach
"It is also reported that a tumor suppressor CYLD deubiquitinase inhibits the ubiquitination of Dvl."
27536874
reach
"Based on the established role of Wnt signaling in self-renewal of the skin, associated cell lineage decisions, and skin appendage formation (Fuchs, 2007), we propose that increased or prolonged activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20227366
CYLD affects CDKN2C
| 3
CYLD deubiquitinates CDKN2C. 3 / 3
| 3
reach
"Knockdown of CYLD significantly increased the polyubiquitylation of p18, whereas, overexpression of CYLD reduced the levels of polyubiquitylation of p18."
33654169
reach
"As expected, CYLD decreased p18 polyubiquitylation in vitro."
33654169
reach
"These data indicate that CYLD directly deubiquitylates p18."
33654169
CYLD affects polyubiquitin chains
| 2
CYLD deubiquitinates polyubiquitin chains on K63. 2 / 2
| 2
reach
"The tumor suppressor cylindromatosis (CYLD) inhibits NFkappaB activation by deubiquitinating K63 polyubiquitin chains on TRAF2, TRAF6, and NEMO [15-17]."
17418100
reach
"Moreover, additional studies showed that CYLD specifically deubiquitinates polyubiquitin chains at K63 of different substrates (e.g., TRAF2 and TRAF6), or tyrosine kinase receptors such as TrkA."
28335430
CYLD affects TRAF7
1 | 1
CYLD deubiquitinates TRAF7. 2 / 2
1 | 1
reach
"CYLD deubiquitinates TRAF6 and TRAF7 to negatively regulate peptidoglycan-induced Toll-Like receptor 2 (TLR2) signaling and inflammation [45]."
32650621
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
CYLD affects RIPK2
1 | 1
CYLD deubiquitinates RIPK2. 2 / 2
1 | 1
reach
"The authors showed that CYLD deubiquitinated RIPK2 in macrophages infected with L. monocytogenes, leading to impaired activation of NF-kappaB, reduced production of proinflammatory cytokines and reactive oxygen and nitrogen species, which ultimately resulted in impaired infection control."
29520263
ubibrowser
"CYLD-mediated K63 deubiquitination of RIPK2 resulted in an impaired activation of both NF-kappaB and ERK1/2 pathways, reduced production of proinflammatory cytokines interleukin-6 (IL-6), IL-12, anti-listerial reactive oxygen species (ROS) and nitric oxide (NO), and, finally, impaired pathogen control."
26834734
CYLD affects PLK1
1 | 1
CYLD deubiquitinates PLK1. 2 / 2
1 | 1
reach
"It is currently unknown how deubiquitylation of PLK1 by CYLD regulates mitotic cell division."
20347313
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
CYLD affects JNK
| 2
CYLD deubiquitinates JNK. 2 / 2
| 2
reach
"CYLD mediated regulation of the JNK signaling pathway appears to target TRAF2 ubiquitylation, as CYLD knockdown increases both TRAF2 ubiquitylation and JNK activation, further enhancing cell survival [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
reach
"We speculate that CYLD could function to deubiquitinate specific substrates in signaling pathways such as NF-κB and JNK, which are well-known to be involved in promoting cancers [39–41]."
33952719
CYLD affects DVL1
1 | 1
CYLD leads to the deubiquitination of DVL1. 2 / 2
1 | 1
ubibrowser
"CYLD negatively regulates the Wnt/β-catenin signaling pathway by deubiquitinating Dvl proteins."
28840581
reach
"Ubiquitination of Dvl1 was diminished by overexpression of wild-type CYLD and enhanced by overexpression of a catalytically inactive CYLD (CYLD C601S)."
20227366
CYLD affects CEP70
1 | 1
CYLD deubiquitinates CEP70. 2 / 2
1 | 1
reach
"It has been shown previously that the cylindromatosis (CYLD) tumor suppressor deubiquitinates Cep70 and promotes its centrosomal localization, thereby contributing to ciliogenesis XREF_BIBR."
26893288
ubibrowser
"The ciliary function of CYLD is attributed to its deconjugation of the polyubiquitin chain from centrosomal protein of 70 kDa (Cep70), a requirement for Cep70 to interact with γ -tubulin and localize at the centrosome"
26763122
CYLD affects AKT1
1 | 1
CYLD leads to the deubiquitination of AKT1. 2 / 2
1 | 1
ubibrowser
"We showed that CYLD was a DUB for Akt and suppressed growth factor-mediated ubiquitination and activation of Akt."
23300340
reach
"Because Akt has three isoforms (Akt1, Akt2 and Akt3), we next examined whether CYLD displays differential specificity for various Akt isoforms and found that CYLD promoted deubiquitination of Akt1 and Akt2 (XREF_SUPPLEMENTARY)."
23300340
CYLD affects plakoglobin
| 1
CYLD deubiquitinates plakoglobin. 1 / 1
| 1
reach
"CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart."
36577382
CYLD affects forkhead
| 1
CYLD deubiquitinates forkhead. 1 / 1
| 1
reach
"CYLD : cylindromatosis; DUB : deubiquitylating enzyme; EBNA : Epstein-Barr nuclear antigen; FOXO : forkhead box O; HAUSP : herpesvirus associated ubiquitin specific peptidase; JAMM : Jab1 and MPN domain associated metalloisopeptidase; MJD : Machado-Joseph disease; OUT : ovarian tumor; PD : Parkinson 's disease; RIP : receptor interacting protein; TNF : tumor necrosis factor; TRAF : tumor necrosis factor receptor associated factor; UBP : ubiquitin processing peptidase; USP : ubiquitin specific peptidase; UCH : ubiquitin C-terminal hydrolase; VHL : von Hippel-Lindau."
19007433
CYLD affects Wnt
| 1
CYLD leads to the deubiquitination of Wnt. 1 / 1
| 1
reach
"Based on the established role of Wnt signaling in self-renewal of the skin, associated cell lineage decisions, and skin appendage formation (Fuchs, 2007), we propose that increased or prolonged activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20227366
CYLD affects USP7
| 1
CYLD deubiquitinates USP7. 1 / 1
| 1
reach
"CYLD : cylindromatosis; DUB : deubiquitylating enzyme; EBNA : Epstein-Barr nuclear antigen; FOXO : forkhead box O; HAUSP : herpesvirus associated ubiquitin specific peptidase; JAMM : Jab1 and MPN domain associated metalloisopeptidase; MJD : Machado-Joseph disease; OUT : ovarian tumor; PD : Parkinson 's disease; RIP : receptor interacting protein; TNF : tumor necrosis factor; TRAF : tumor necrosis factor receptor associated factor; UBP : ubiquitin processing peptidase; USP : ubiquitin specific peptidase; UCH : ubiquitin C-terminal hydrolase; VHL : von Hippel-Lindau."
19007433
CYLD affects TRIP12
1 |
CYLD deubiquitinates TRIP12. 1 / 1
1 |
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
CYLD affects TNFRSF1A
| 1
CYLD leads to the deubiquitination of TNFRSF1A. 1 / 1
| 1
reach
"CYLD, a deubiquitinating enzyme that targets both M1- and K63 linked ubiquitin chains, is recruited to TNF-RSC to negatively regulate ubiquitinations of RIPK1, TNFR1, NEMO and TRADD to attenuate the NF-kappaB pathway and promote both apoptosis and necroptosis."
27984721
CYLD affects TNF
| 1
CYLD leads to the deubiquitination of TNF. 1 / 1
| 1
reach
"The DUB function of CYLD was first revealed by in vitro work showing that CYLD inhibits the ubiquitination of certain TNF receptor associated factors and the regulatory subunit of IkappaB kinase."
17548520
CYLD affects TNF receptor
| 1
CYLD leads to the deubiquitination of TNF receptor. 1 / 1
| 1
reach
"The DUB function of CYLD was first revealed by in vitro work showing that CYLD inhibits the ubiquitination of certain TNF receptor associated factors and the regulatory subunit of IkappaB kinase."
17548520
CYLD affects TGFBR1
1 |
CYLD deubiquitinates TGFBR1. 1 / 1
1 |
ubibrowser
"Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma"
29235674
CYLD affects TGFB
| 1
CYLD leads to the deubiquitination of TGFB. 1 / 1
| 1
reach
"Reversely, CYLD negatively regulates Akt signaling by deubiquitinating Akt in TGFbeta signaling [XREF_BIBR]."
27119228
CYLD affects TAB1
| 1
CYLD leads to the deubiquitination of TAB1. 1 / 1
| 1
reach
"CYLD does not inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination."
21331078
CYLD affects RIPK3
| 1
CYLD deubiquitinates RIPK3. 1 / 1
| 1
reach
"CYLD deficiency leads to hyperubiquitinated RIPK1 in the necrosome and impaired phosphorylation of RIPK1 and RIPK3, thereby blocking caspase-8 activation."
26491219
CYLD affects RIPK
| 1
CYLD leads to the deubiquitination of RIPK on A20. 1 / 1
| 1
reach
"It is assumed that complex IIB contains deubiquitylated RIP caused by CYLD and A20."
21151032
CYLD affects NR2C2
1 |
CYLD deubiquitinates NR2C2. 1 / 1
1 |
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
CYLD affects NOX4
1 |
CYLD deubiquitinates NOX4. 1 / 1
1 |
ubibrowser
"Moreover, Nox4 was deubiquitinated via a direct interaction with the ubiquitin-specific protease domain of CYLD."
28751569
CYLD affects NDRG1
| 1
CYLD leads to the deubiquitination of NDRG1. 1 / 1
| 1
reach
"Given that CYLD is a deubiquitinase, we hypothesized that CYLD might inhibit NDRG1 ubiquitination and degradation via the ubiquitin-proteasome pathway."
33149672
CYLD affects NADP(+)
| 1
CYLD deubiquitinates NADP(+). 1 / 1
| 1
reach
"CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling."
28751569
CYLD affects MYD88
| 1
CYLD leads to the deubiquitination of MYD88. 1 / 1
| 1
reach
"Although it is unclear whether this ubiquitination event is mediated by TRAF6 or another E3, the ubiquitination of MyD88 is negatively regulated by the DUB CYLD and is important for activating downstream proinflammatory signaling."
27012466
CYLD affects MAPK3
| 1
CYLD deubiquitinates MAPK3. 1 / 1
| 1
reach
"CYLD was also ineffective in deubiquitinating and inactivating ERK1 (Fig. 6c and Extended Data Fig. 6c), although it was fully capable of deubiquitinating another substrate, TRAF2 (Extended Data Fig. 6d) ."
34497368
CYLD affects LCK
1 |
CYLD deubiquitinates LCK. 1 / 1
1 |
ubibrowser
"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
CYLD affects JUN
| 1
CYLD leads to the deubiquitination of JUN. 1 / 1
| 1
reach
"CYLD suppresses AP1 function by regulating c-Jun and c-Fos ubiquitination."
21478324
CYLD affects IL6
| 1
CYLD leads to the deubiquitination of IL6. 1 / 1
| 1
reach
"In vivo, CYLD also reduced hepatic STAT3 K63 ubiquitination and activation, NF-kappaB activation, IL-6 and NOX2 mRNA production as well as fibrin production in murine listeriosis."
23825949
CYLD affects IKKgamma subunit
| 1
CYLD leads to the deubiquitination of IKKgamma subunit. 1 / 1
| 1
reach
"The tumor suppressor CYLD inhibits the NF-kappaB pathway at multiple steps by deubiquitinating the IKKgamma subunit, TRAF2, TRAF6, and BCL3 (Brummelkamp et al., 2003; Kovalenko et al., 2003; Massoumi [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17692804
CYLD affects GSK3B
| 1
CYLD leads to the deubiquitination of GSK3B. 1 / 1
| 1
reach
"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
28412322
CYLD affects FOXO3
| 1
CYLD leads to the deubiquitination of FOXO3. 1 / 1
| 1
reach
"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
28412322
CYLD affects FOXO
| 1
CYLD deubiquitinates FOXO. 1 / 1
| 1
reach
"CYLD : cylindromatosis; DUB : deubiquitylating enzyme; EBNA : Epstein-Barr nuclear antigen; FOXO : forkhead box O; HAUSP : herpesvirus associated ubiquitin specific peptidase; JAMM : Jab1 and MPN domain associated metalloisopeptidase; MJD : Machado-Joseph disease; OUT : ovarian tumor; PD : Parkinson 's disease; RIP : receptor interacting protein; TNF : tumor necrosis factor; TRAF : tumor necrosis factor receptor associated factor; UBP : ubiquitin processing peptidase; USP : ubiquitin specific peptidase; UCH : ubiquitin C-terminal hydrolase; VHL : von Hippel-Lindau."
19007433
CYLD affects FOS
| 1
CYLD leads to the deubiquitination of FOS. 1 / 1
| 1
reach
"CYLD suppresses AP1 function by regulating c-Jun and c-Fos ubiquitination."
21478324
CYLD affects EBNA
| 1
CYLD deubiquitinates EBNA. 1 / 1
| 1
reach
"CYLD : cylindromatosis; DUB : deubiquitylating enzyme; EBNA : Epstein-Barr nuclear antigen; FOXO : forkhead box O; HAUSP : herpesvirus associated ubiquitin specific peptidase; JAMM : Jab1 and MPN domain associated metalloisopeptidase; MJD : Machado-Joseph disease; OUT : ovarian tumor; PD : Parkinson 's disease; RIP : receptor interacting protein; TNF : tumor necrosis factor; TRAF : tumor necrosis factor receptor associated factor; UBP : ubiquitin processing peptidase; USP : ubiquitin specific peptidase; UCH : ubiquitin C-terminal hydrolase; VHL : von Hippel-Lindau."
19007433
CYLD affects E3_Ub_ligase
| 1
CYLD deubiquitinates E3_Ub_ligase. 1 / 1
| 1
reach
"As it has previously been demonstrated that CYLD deubiquitinates TRAF6 these results suggests that CYLD deubiquitinates and suppresses the activity of both the E3 ligase and its kindred substrate [184[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
CYLD affects Death
| 1
CYLD deubiquitinates Death. 1 / 1
| 1
reach
"Conversely, disrupting CYLD phosphorylation using IKK inhibitors reactivates CYLD, which in turn, deubiquitinates and switches RIPK1 into a death-signaling molecule (Fig. 8b)."
32024820
CYLD affects DLG4
1 |
CYLD deubiquitinates DLG4. 1 / 1
1 |
ubibrowser
"CYLD-mediated PSD-95 deubiquitination, mobilizing and depleting PSD-95 from synapses."
28973854
CYLD affects Complex I components
| 1
CYLD deubiquitinates Complex I components. 1 / 1
| 1
reach
"A20- and cylindromatosis (CYLD)-mediated deubiquitylation of Complex I components induces disassembly of Complex I. Subsequently either cytosolic Complex IIa or Complex IIb is formed [XREF_BIBR]."
26726307
CYLD affects CYBB
| 1
CYLD leads to the deubiquitination of CYBB. 1 / 1
| 1
reach
"In vivo, CYLD also reduced hepatic STAT3 K63 ubiquitination and activation, NF-kappaB activation, IL-6 and NOX2 mRNA production as well as fibrin production in murine listeriosis."
23825949
CYLD affects CNTN2
1 |
CYLD deubiquitinates CNTN2. 1 / 1
1 |
ubibrowser
"RESULTS: We show here that the deubiquitinase CYLD physically interacts with Tax and negatively regulates the ubiquitination of this viral protein."
21824392
CYLD affects CENPV
| 1
CYLD deubiquitinates CENPV. 1 / 1
| 1
reach
"CENPV is deubiquitylated by CYLD and localizes in interphase to primary cilia where it increases the ciliary levels of acetylated alpha-tubulin."
31260673
CYLD affects BCL2L11
| 1
CYLD leads to the deubiquitination of BCL2L11. 1 / 1
| 1
reach
"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
28412322
CYLD affects AKT2
| 1
CYLD leads to the deubiquitination of AKT2. 1 / 1
| 1
reach
"Because Akt has three isoforms (Akt1, Akt2 and Akt3), we next examined whether CYLD displays differential specificity for various Akt isoforms and found that CYLD promoted deubiquitination of Akt1 and Akt2 (XREF_SUPPLEMENTARY)."
23300340