IndraLab

Statements

CYLD deubiquitinates RIPK3. 3 / 3
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"CYLD acts as a negative regulator of necroptosis by deubiquitinating RIPK1 and RIPK3, thereby preventing their activation."
37719475
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"CYLD deficiency leads to hyperubiquitinated RIPK1 in the necrosome and impaired phosphorylation of RIPK1 and RIPK3, thereby blocking caspase-8 activation."
26491219
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"In addition, deubiquitination of RIPK3 by CYLD increases its stability, making it more susceptible to forming a complex with RIPK1 and activating MLKL.Ubiquitination of MLKL regulates its activity and membrane localization, and unubiquitinated MLKL binds more readily to RIPK3 and receives phosphorylation, resulting in oligomerization and translocation to the plasma membrane (39)."
39720715