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CYLD deubiquitinates TRAF6. 32 / 34
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"In contrast, CYLD can deubiquitinate the upstream regulatory factors of NF-κB, such as tumor necrosis factor receptor-associated factor (TRAF) 2, TRAF6, and NEMO 49-51, preventing excessive activation of NF-κB through negative feedback 52."
40083930
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"CYLD deubiquitinates TRAF2, TRAF6 and NEMO, and inactivation of CYLD increases NF-ĸB signaling in a sustained manner, both in vitro and in vivo [43]."
39334439
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"In the absence of any robust stimulation of NF-kappaB (such as TCR engagement or cytokine signaling), CYLD deubiquitylates TRAF2, TRAF6, and NEMO, dampening NF-kappaB signaling by removing activating K63 chains formed by TRAF2/6."
26732666
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"For instance, p62, one adaptor protein, can promote the deubiquitylation of TRAF6 (one of p62 targets) by CYLD."
32850399
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"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
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"Then we investigated the roles A20 and CYLD in CK8 mediated inhibition of TRAF6 ubiquitination."
27586056
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"CYLD binding to one of its targets, TRAF6, requires the adaptor protein p62, which promotes the deubiquitylation of TRAF6 by CYLD 17 and probably also modulates the DUB activity of CYLD through induction of CYLD ubiquitylation 34."
18535581
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"Previously it has been known that TNF receptor associated factor 6 (TRAF6) acts as an E3 ligase for Akt-K63 polyubiquitination, and CYLD deubiquitinates TRAF6."
22491319
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"CYLD deubiquitylates TRAF6, which transduces the RANK-mediated signal [99]."
30123285
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"CYLD attenuates NF-κB activity by regulating the ubiquitination of NEMO, TRAF2, TRAF6, and TAK1, which are important signaling elements constituting the NF-κB pathway [ 16–18 ]."
35131382
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"Conversely, the PB1 domain of p62 also interacts with CYLD, a deubiquitinase, which inhibits TRAF6 polyubiquitination and serves as a negative regulator for RANK mediated NF-kappaB activation and osteoclastogenesis 113."
23856904
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"al reported that G protein-coupled receptor kinase interactor 2 (GIT2)- deficient mice were reported to be more susceptible to DSS-induced colitis, and the potential mechanism was that GIT2 could term[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33190004
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"In addition to CYLD, Nur77, an immediate-early response gene, could negatively regulate the activation of TLR–IL-1R signaling by preventing auto-ubiquitination and oligomerization of TRAF6 and subsequ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33190004
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"In support of this notion, in vivo poly-ubiquitination assays demonstrate that depletion of beta-TRCP impaired TRAF6 self ubiquitination likely due to enhancement of TRAF6 deubiquitination by CYLD, concomitant with a reduction in beta-TRCP-dependent ubiquitination of CYLD and impairment of auto-phosphorylation of TRAF6-downstream kinase IKKalpha."
24961988
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"Here we demonstrated that during the RANKL dependent signaling pathway, CYLD stabilization by depletion of beta-TRCP decreased the ubiquitination of TRAF6 and impaired auto-phosphorylation of the TRAF6-downstream kinase IKKalpha."
24961988
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"Because these mutations cause loss of the domains that are required for CYLD-TRAF6 or CYLD-p62 interactions, the truncated CYLD can no longer associate with these proteins and deubiquitinate TRAF6."
26276688
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"Specifically, as suggested by Jin et al. [XREF_BIBR], deubiquitinating enzyme CYLD negatively regulated TRAF6 ubiquitination by interacting with P62 and subsequently inhibited proangiogenesis function of TRAF6."
29081889
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"By deubiquitinating TRAF2/TRAF6, NF-κB essential modifier (NEMO), CYLD, acts as a key regulator in the typical p65/NF-κB pathway [19, 20]."
38907316
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"Considerable research suggests that CYLD mainly inhibits the ubiquitination of TRAF6 [10,27,28]."
38254792
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"CYLD negatively regulates osteoclast RANK signaling by inhibiting TRAF6 ubiquitination."
38254792
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"We further provide evidence to show that CYLD inhibits ubiquitinating TRAF-6 probably through directly interacting with sNASP."
40108019
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"CYLD inhibits TRAF6 polyubiquitination through sNASP."
40108019
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"CYLD deubiquitinates TRAF6 and TRAF7 to negatively regulate peptidoglycan-induced Toll-Like receptor 2 (TLR2) signaling and inflammation [45]."
32650621
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"However, loss of CYLD increased TRAF6 polyubiquitination in PP4-overexpressing THP-1 cells (Fig. 5A)."
40108019
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"[XREF_BIBR] CYLD deubiquitination of TRAF6, RIP1, and NF-kappaB-essential modulator (NEMO) leads to inactivation of NF-kappaB signaling."
25025000
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
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"For example, CYLD can deubiquitinate TRAF6, a key protein downstream of RANKL, and negatively regulate osteoclast formation [31]."
37333461
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"For example, the deubiquitination (DUB) enzyme A20 or CYLD switches off NF-κB signaling by deubiquitinating TRAF6 upstream of IKK [11–13] , and UBXN1 is expected to block IKK phosphorylation and subse[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30844390
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
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"OPTN negatively regulates IRAK-1 mediated NF-kappaB activation possibly by facilitating CYLD dependent deubiquitination of TRAF6."
29951055
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"As it has previously been demonstrated that CYLD deubiquitinates TRAF6 these results suggests that CYLD deubiquitinates and suppresses the activity of both the E3 ligase and its kindred substrate [184[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
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"K63-linked poly-ubiquitination is significant for the activation of TRAF6, deubiquitinase A20, CYLD and USP20 have been reported to inhibit signal pathway transduction by removing the ubiquitination o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35074523