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CYLD deubiquitinates TP53. 13 / 13
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"This experiment showed that CYLD diminishes p53 ubiquitination in cells expressing HA-mutant ubiquitin forming K63 only chains, but also in cells expressing HA-mutant ubiquitin forming K48 only chains (XREF_FIG)."
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"CYLD deubiquitinates and stabilizes p53, which serves as a transcriptional factor to positively regulate m7G Methyltransferase1 (Mettl1) in MIRI mouse model."
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"Thus, overexpression of CYLD and anti-apoptotic proteins may increase cell survival as a result of positive feedback signaling.CYLD directly interacts with and deubiquitinates p53, promoting DNA damage-induced p53 stabilization and activation in response to oxidative stress-induced genotoxicity."
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"CYLD interacts with and deubiquitinates p53 in response to DNA damage (40) and therefore affects genomic instability."
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"Mechanistically, <span class="match term0">CYLD</span> interacts with and deubiquitinates <span class="match term1">p53</span> facilitating its stabilization in response to genotoxic stress."
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"Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in response to genotoxic stress."
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"Mechanistically, we show that CYLD interacts with and deubiquitinates p53 in response to DNA damage."
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"CYLD deubiquitinates p53 facilitating its stabilization."
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"Collectively, these findings indicated that CYLD deubiquitinated p53 to enhance its stability and nuclear translocation.Simultaneous knockdown of CYLD and p53 enhanced the biological effects of PFKFB3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in XREF_FIG and XREF_SUPPLEMENTARY, in contrast to WT CYLD, the catalytically inactive CYLDR936X (R/X) and CYLDH871N (H/N) mutants did not diminish p53 ubiquitination although they bound p53, demonstrating that CYLD DUB activity is required to reduce p53 ubiquitination."
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"Furthermore, recombinant His CYLD reduced ubiquitination of Flag-p53 immunoprecipitated from CpT treated HEK293T cells, showing that CYLD can directly deubiquitinate p53 in a cell-free in vitro assay (XREF_SUPPLEMENTARY)."
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"Together, these results suggested that CYLD directly interacts with and deubiquitinates p53 facilitating its optimal stabilization in response to DNA damage."
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"To address this question, we first assessed the capacity of CYLD to reduce p53 ubiquitination in cells overexpressing HA tagged Lys-to-Arg ubiquitin mutants that can only form K48- or K63 linked chains."
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