IndraLab

Statements

CYLD deubiquitinates BCL3. 12 / 12
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"The CYLD protein deubiquitinates Bcl-3 and inhibits its nuclear translocation, so alterations in these gene or upstream events to it present an additional layer of regulation."
22195643
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"CYLD is also able to deubiquitinate Bcl-3 and prevent it from entering nucleus, where Bcl-3 can interact with NFkappaB family members (p50 and p52) to activate the transcription of NFkappaB target genes."
19037995
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"In addition to its deubiquitination effects on TRAFs and IKKgamma, CYLD also deubiquitinates Bcl-3, and in so doing prevents its nuclear localization."
18977328
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"CYLD deubiquitinates several NF-kappaB regulators, including TRAF2, TRAF6, and NEMO as well as BCL3, a member of the NF-kappaB family of transcription factors."
19481526
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"CYLD deubiquitylates BCL-3 inhibiting its nuclear translocation and so decreases the transcription of BCL-3 target genes including CCND [XREF_BIBR]."
28900014
ubibrowser
"In this region, CYLD associates with its substrate Bcl-3 and prevents the nuclear localization of Bcl3"
26763122
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"In the present study, the cytoplasmic and perinuclear expression levels of CYLD suggest that CYLD may play a role in the deubiquitination of BCl-3 and/or TRAF in NF-kappaB signaling within the cytoplasm or perinuclear region in keratinocytes of normal skin and cholesteatoma, in agreement with previously reported results."
20414373
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"In these cases, mutated CYLD is unable to deubiquitinate Bcl-3, allowing increased proliferation in cell of the skin adnexa [XREF_BIBR]."
22195643
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"In this issue of Cell, Massoumi et al. (2006) show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-kappaB and activates transcription of proliferation genes in response to growth signals."
16713556
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"As for CYLD, studies have shown that CYLD binds to and deubiquitylates BCL-3 inhibiting its nuclear translocation, leading to decreased transcription of CCND, and delayed cells from entering S-phase 35."
33654169
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"In our experiments, the inhibitory effect of CYLD on the nuclear accumulation of phosphorylated STAT3 resembles CYLD-Bcl3 interaction, since CYLD also deubiquitinates Bcl-3 in perinuclear regions and prevents its translocation to the nucleus, a process which significantly contributes to the development of keratinocyte hyperproliferation and development of benign tumors of the skin appendage called cylindromatosis XREF_BIBR."
23825949
signor
"Cyld binds and deubiquitinates bcl-3in cyld+/+ keratinocytes, tpa or uv light triggers the translocation of cyld from the cytoplasm to the perinuclear region, where cyld binds and deubiquitinates bcl-3, thereby preventing nuclear accumulation of bcl-3 and p50/bcl-3- or p52/bcl-3-dependent proliferation."
16713561