IndraLab

Statements

CYLD deubiquitinates BCL3. 12 / 12
1 1 | 10
signor
"Cyld binds and deubiquitinates bcl-3in cyld+/+ keratinocytes, tpa or uv light triggers the translocation of cyld from the cytoplasm to the perinuclear region, where cyld binds and deubiquitinates bcl-3, thereby preventing nuclear accumulation of bcl-3 and p50/bcl-3- or p52/bcl-3-dependent proliferation."
16713561
reach
"As for CYLD, studies have shown that CYLD binds to and deubiquitylates BCL-3 inhibiting its nuclear translocation, leading to decreased transcription of CCND, and delayed cells from entering S-phase 35."
33654169
reach
"CYLD deubiquitylates BCL-3 inhibiting its nuclear translocation and so decreases the transcription of BCL-3 target genes including CCND [XREF_BIBR]."
28900014
reach
"It has been shown that CYLD deubiquitinate Bcl-3 and thereby preventing its entry into the nucleus."
19835866
reach
"In addition to its deubiquitination effects on TRAFs and IKKgamma, CYLD also deubiquitinates Bcl-3, and in so doing prevents its nuclear localization."
18977328
ubibrowser
"In this region, <span class="match term0">CYLD</span> associates with its substrate Bcl-3 and prevents the nuclear localization of <span class="match term1">Bcl3</span>"
26763122
reach
"The CYLD protein deubiquitinates Bcl-3 and inhibits its nuclear translocation, so alterations in these gene or upstream events to it present an additional layer of regulation."
22195643
reach
"In the present study, the cytoplasmic and perinuclear expression levels of CYLD suggest that CYLD may play a role in the deubiquitination of BCl-3 and/or TRAF in NF-kappaB signaling within the cytoplasm or perinuclear region in keratinocytes of normal skin and cholesteatoma, in agreement with previously reported results."
20414373
reach
"In these cases, mutated CYLD is unable to deubiquitinate Bcl-3, allowing increased proliferation in cell of the skin adnexa [XREF_BIBR]."
22195643
reach
"CYLD deubiquitinates several NF-kappaB regulators, including TRAF2, TRAF6, and NEMO as well as BCL3, a member of the NF-kappaB family of transcription factors."
19481526
reach
"CYLD is also able to deubiquitinate Bcl-3 and prevent it from entering nucleus, where Bcl-3 can interact with NFkappaB family members (p50 and p52) to activate the transcription of NFkappaB target genes."
19037995
reach
"In our experiments, the inhibitory effect of CYLD on the nuclear accumulation of phosphorylated STAT3 resembles CYLD-Bcl3 interaction, since CYLD also deubiquitinates Bcl-3 in perinuclear regions and prevents its translocation to the nucleus, a process which significantly contributes to the development of keratinocyte hyperproliferation and development of benign tumors of the skin appendage called cylindromatosis XREF_BIBR."
23825949