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CYLD deubiquitinates TBK1. 8 / 9
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"Our results led us to propose a model for the regulation of TBK1 activity by Optn ( Fig. 3 A): In uninfected cells, the complex formed by TBK1, Optn and CYLD constitutively deubiquitinates and inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26976762
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"CYLD also inhibits the ubiquitylation of TBK1 and IKKɛ, which contributes to the negative regulation of IFN responses ."
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"CYLD targets the cytoplasmic RNA sensor RIG-I and inhibits the polyubiquitination of this IKKi/TBK1 stimulator [77] ( Fig. 2 )."
18707898
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"Our study confirmed that this inhibitory function is dependent both on S177 phosphorylation of Optn and on its ability to interact with ubiquitinated proteins, but also showed that the Optn-related in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26976762
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"CYLD also deubiquitinates RIG-I and TBK1 to suppress Sendai virus-induced antiviral responses [16]."
39158695
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"In addition, CYLD also inhibits the ubiquitination of TBK1 and IKKepsilon, which also contributes to the negative regulation of IFN responses by CYLD 79."
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"CYLD overexpression decreased RIG-I, TBK1, and IKKε ubiquitination [16]."
39158695
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"XREF_BIBR, XREF_BIBR We and others have recently shown that RIG-I ubiquitination and TBK1 and IKKepsilon activation are negatively regulated by CYLD, XREF_BIBR, XREF_BIBR a deubiquitinase known to digest K63 linked ubiquitin chains."
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