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CYLD deubiquitinates RIGI. 12 / 12
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"XREF_BIBR, XREF_BIBR We and others have recently shown that RIG-I ubiquitination and TBK1 and IKKepsilon activation are negatively regulated by CYLD, XREF_BIBR, XREF_BIBR a deubiquitinase known to digest K63 linked ubiquitin chains."
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"Recently, the deubiquitinating enzyme CYLD has been shown to negatively regulate ubiquitination of the RIG-I RNA sensor and thus inhibit the IFN response [86,87] ."
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"In contrast, CYLD deficiency enhances IAV-induced RIG-I and TAK1 ubiquitination and innate antiviral immunity."
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"CYLD has been shown to deubiquitinate, or prevent ubiquitination of RIG-I in cells."
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"CYLD (cylindromatosis) deubiquitinates RIG-I and several downstream molecules to prevent premature RIG-I activation in uninfected cells [XREF_BIBR], while USP3 deubiquitinates RIG-I specifically after viral infection, likely serving as a negative feedback regulator [XREF_BIBR]."
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"A simple explanation for this result is that the carboxyl-terminal fragment of SDC4 brings RIG-I and CYLD close together, which promotes the deubiquitination of RIG-I by CYLD."
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"SDC4 likely promotes redistribution of <span class="match term1">RIG-I</span> and <span class="match term0">CYLD</span> in a perinuclear pattern post viral infection, and thus enhances the <span class="match term1">RIG-I</span>-<span class="match term0">CYLD</span> interaction and potentiates the K63-linked deubiquitination of <span class="match term1">RIG-I</span>."
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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"CYLD also deubiquitinates RIG-I and TBK1 to suppress Sendai virus-induced antiviral responses [16]."
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"CYLD overexpression decreased RIG-I, TBK1, and IKKε ubiquitination [16]."
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"Consistent with these observations, our study showed that CYLD deficiency significantly enhanced TAK1 and RIG-I ubiquitination in IAV-infected cells (Fig. 9), leading to increased innate immunity."
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"CYLD can inhibit ubiquitination of the RIG1 cytoplasmic viral RNA sensor and also downregulate antiviral Interferon production by controlling IKK activation [XREF_BIBR]."
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