IndraLab

Statements


CYLD deubiquitinates SMAD7. 3 / 3
1 | 2

reach
"CYLD deubiquitinates Smad7 and inhibits TGF-β signaling (58)."

"This showed that <span class="match term0">CYLD</span> can bind to <span class="match term1">SMAD7</span> and deubiquitinate <span class="match term1">SMAD7</span> at Lysine 360 and 374 residues, which are required for the activation of TAK1 and p38 signaling"

reach
"CYLD deubiquitinates Smad7 and thereby inhibits the activation of TAK1 and p38, thus inhibiting the TGFbeta induced development of regulatory T cells."