IndraLab

Statements

CYLD deubiquitinates STING1. 3 / 3
| 3
reach
"Notably, the CYLD USP domain also deubiquitinated STING in vitro (S6D Fig), which is consistent with our observation in S4E Fig. To substantiate this finding, we transfected Flag-STING along with HA-tagged WT ubiquitin or ubiquitin mutants in the presence or absence of CYLD, followed by immunoblotting."
30388174
reach
"Therefore, STING translocated from the ER to the Golgi upon HSV-1 stimulation, and CYLD partially accumulated with STING to promote STING deubiquitination."
30388174
reach
"We also confirmed that human CYLD and murine CYLD deubiquitinated STING in vitro, but the catalytically dead mutants (human CYLD C601S and murine CYLD C597S) could not perform the same function (S6D and S6E Fig)."
30388174