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CYLD leads to the deubiquitination of AKT1. 2 / 2

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"Because Akt has three isoforms (Akt1, Akt2 and Akt3), we next examined whether CYLD displays differential specificity for various Akt isoforms and found that CYLD promoted deubiquitination of Akt1 and Akt2 (XREF_SUPPLEMENTARY)."

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"We showed that CYLD was a DUB for Akt and suppressed growth factor-mediated ubiquitination and activation of Akt"

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IndraLab

Statements

CYLD leads to the deubiquitination of AKT1. 2 / 2

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