IndraLab

Statements

CYLD deubiquitinates AKT. 11 / 11
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"Reversely, CYLD negatively regulates Akt signaling by deubiquitinating Akt in TGFbeta signaling [XREF_BIBR]."
27119228
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"Because CYLD suppresses ubiquitination and activation of Akt, it is possible that CYLD may also inhibit cancer cell proliferation and survival."
23300340
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"In line with this, the loss of CYLD promotes Akt hyperubiquitination and activation, as well as cell proliferation, survival and prostate tumorigenesis [120]."
36769122
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"Among the DUBs, only CYLD effectively reduced the ubiquitination of Akt (XREF_FIG and XREF_SUPPLEMENTARY)."
23300340
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"Noteworthily, the CYLD-mediated deubiquitination of Akt induced by bisdemethoxycurcumin has been shown to inhibit hepatocellular carcinoma cell growth [121]."
36769122
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"To determine whether CYLD is a direct DUB for Akt, we performed in vitro deubiquitination assays and found that deubiquitination of Akt was mediated by wild-type CYLD but not the C601A mutant (XREF_FIG)."
23300340
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"Both E3 ligases TRAF6 [158] and Skp2 [159] regulate Akt activity through K63 linked ubiquitination while CYLD promotes deubiquitination of Akt [160]."
30217566
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"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
28412322
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"Because CYLD is a known deubiquitinase and Akt ubiquitination is critical for its functional activity XREF_BIBR, we next investigated whether CYLD deubiquitinates Akt."
22491319
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"PI3K/AKT signalling-related pathways, including Wnt, Notch, Shh, NF-κβ, and JNK signalling pathways, are deubiquitinated by CYLD, which functions as a negative regulator [ 100 ]."
38035995
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"In this study we provided experimental evidences for direct interaction between Akt and CYLD, and also showed that CYLD does directly deubiquitinate Akt under both endogenous and exogenous conditions."
22491319