IndraLab

Statements

CYLD deubiquitinates NLRP6. 6 / 6
| 6
reach
"For the regulation of the NLRP6 inflammasome, Mukherjee et al. [107] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld, which mediates deubiquitination of NLRP6; as a consequence, Cyld inhibits NLRP6-ASC assembly and IL-18 production."
33808793
reach
"Cyld deubiquitinated NLRP6, suggesting that Cyld directly deubiquitinates NLRP6 (XREF_FIG)."
32424362
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"To confirm that Cyld directly deubiquitinates NLRP6, we coexpressed Flag -- NLRP6 with Ub."
32424362
reach
"Coexpression of Cyld with NLRP6 and UbK63 markedly inhibited ubiquitination of NLRP6 (XREF_FIG, lane 4), suggesting that Cyld cleaves K63 linked Ub chains."
32424362
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"NLRP6 ubiquitination was diminished in the presence of wild-type Cyld but not with the Cyld (C601A) deubiquitinase defective mutant, suggesting that Cyld deubiquitinates NLRP6 (XREF_FIG)."
32424362
reach
"Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation."
32424362