IndraLab

Statements

CYLD deubiquitinates NLRP6. 8 / 9
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"Cyld deubiquitinated NLRP6, suggesting that Cyld directly deubiquitinates NLRP6 (XREF_FIG)."
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"For the regulation of the NLRP6 inflammasome, Mukherjee et al. [107] found that the assembly of this inflammasome was regulated by deubiquitinase Cyld, which mediates deubiquitination of NLRP6; as a consequence, Cyld inhibits NLRP6-ASC assembly and IL-18 production."
33808793
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"The ubiquitin carboxyl-terminal hydrolase CYLD prevents excessive IL-18 production by deubiquitinating NLRP6 and impairing inflammasome formation, thus preventing excessive inflammation ."
35650327
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"Furthermore, in patients with ulcerative colitis elevated levels of IL-18 inversely correlate with CYLD expression, suggesting that CYLD deubiquitination of NLRP6 could be a new therapeutic approach for treating intestinal inflammation ."
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"Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation."
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"NLRP6 ubiquitination was diminished in the presence of wild-type Cyld but not with the Cyld (C601A) deubiquitinase defective mutant, suggesting that Cyld deubiquitinates NLRP6 (XREF_FIG)."
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"Coexpression of Cyld with NLRP6 and UbK63 markedly inhibited ubiquitination of NLRP6 (XREF_FIG, lane 4), suggesting that Cyld cleaves K63 linked Ub chains."
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"To confirm that Cyld directly deubiquitinates NLRP6, we coexpressed Flag -- NLRP6 with Ub."
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