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CYLD deubiquitinates LCK. 3 / 3
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"By deubiquitinating the Src kinase Lck, CYLD promotes the development of CD4 and CD8 positive T cells in thymus and periphery [36] ."
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"As a positive regulator in thymocytes, CYLD mediates Lck deubiquitination and promotes CD4 + cell differentiation [57,62] In CYLD-deficient mice, multiple roles of CYLD were implicated in immune cell [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Other identified <span class="match term0">CYLD</span> substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (<span class="match term1">LCK</span>), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
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