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CYLD deubiquitinates LCK. 2 / 3
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"By deubiquitinating the Src kinase Lck, CYLD promotes the development of CD4 and CD8 positive T cells in thymus and periphery [36] ."
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"As a positive regulator in thymocytes, CYLD mediates Lck deubiquitination and promotes CD4 + cell differentiation [57,62] In CYLD-deficient mice, multiple roles of CYLD were implicated in immune cell [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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