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CYLD deubiquitinates TRAF2. 18 / 18
1 1 | 16
signor
"Cyld also interacts directly with tumour-necrosis factor receptor (tnfr)-associated factor 2 (traf2), an adaptor molecule involved in by members of the family of tnf/nerve growth factor receptors. (articolo-abstract)"
12917691
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"Using an shRNA approach, Brummelkamp et al. showed that CYLD inhibits NF-kappaB signaling by counteracting TRAF2 ubiquitination [XREF_BIBR]."
21119682
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"The steady state association of TRAF2 with MLKL was diminished upon TNF induced necroptosis induction, and this correlated with CYLD dependent deubiquitylation of TRAF2."
27158445
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
reach
"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
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"Here we described that the adenoviral vector expressing CYLD (Ad/hTERT-CYLD) augmented the cytotoxicity of TRAIL in HCC cells by negatively regulating NF-kappaB activity since CYLD could reverse the ubiquitination of TNF receptor associated factor 2 (TRAF2) and interact with the IkappaB kinasegamma (IKKgamma)."
16627981
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"Contributing to the " death signal ", CYLD deubiquitylates TRAF2 and RIPK1, allowing the formation of the ripoptosome."
| PMC
reach
"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
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"Because the target of CYLD in the NF-kappaB pathway is known to be deubiquitination of TRAF2, we also confirmed the deubiquitination of TRAF2 by CYLD in ECs."
18245814
ubibrowser
"We conclude that PrP traps CYLD, preventing it from binding and deubiquitinating RIP1 and TRAF2."
28900035
reach
"In the absence of any robust stimulation of NF-kappaB (such as TCR engagement or cytokine signaling), CYLD deubiquitylates TRAF2, TRAF6, and NEMO, dampening NF-kappaB signaling by removing activating K63 chains formed by TRAF2/6."
26732666
reach
"For instance, CYLD deubiquitinates the K63-Ub chains of TRAF2 and, to some extent, TRAF6, and inhibits NF-kappaB activity."
19392652
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"CYLD, a protease that specifically cleaves K63-ubiquitin chains, de-ubiquitinates TRAF2, thereby inhibiting the recruitment of TAB and TAK and activation of IKK [15], and A20 deactivates RIP1 by remov[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24746195
reach
"CYLD mediated regulation of the JNK signaling pathway appears to target TRAF2 ubiquitylation, as CYLD knockdown increases both TRAF2 ubiquitylation and JNK activation, further enhancing cell survival [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
reach
"To verify this hypothesis, we examined CYLDex7/8 -/- mice, which lack the full CYLD molecule but overexpress a shorter CYLD isoform (sCYLD) that is unable to bind to and thus deubiquitinate TRAF2."
25824820
reach
"In this study, we also confirmed that CYLD deubiquitinated TRAF2, leading to inactivation of the NF-kappaB pathway in ECs, although CYLD may have other targets to suppress NF-kappaB activity."
18245814
reach
"An example is CYLD which suppress the ubiquitination of TNF receptor associated factor 2 (TRAF2)."
23797609
reach
"Under normal conditions, CYLD dominantly suppresses the ubiquitination of TRAF2."
15870263