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CYLD deubiquitinates TRAF2. 28 / 30
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"Another example is already mentioned CYLD, which is an important inflammatory mediator that deubiquitinates TRAF2 and TRAF6, resulting in negative regulation of the NF-kappaB pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23151130
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"CYLD deubiquitinates TRAF2, TRAF6 and NEMO, and inactivation of CYLD increases NF-ĸB signaling in a sustained manner, both in vitro and in vivo [43]."
39334439
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"CYLD, a protease that specifically cleaves K63-ubiquitin chains, de-ubiquitinates TRAF2, thereby inhibiting the recruitment of TAB and TAK and activation of IKK [15], and A20 deactivates RIP1 by remov[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24746195
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"A series of recent reports have shown that CYLD blocks signal transmission through the classical NF-κB cascade by deubiquitinating the TNF receptor-associated factor 2 (TRAF2), TRAF6, and IKK-γ (NEMO)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16713556
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"In the absence of any robust stimulation of NF-kappaB (such as TCR engagement or cytokine signaling), CYLD deubiquitylates TRAF2, TRAF6, and NEMO, dampening NF-kappaB signaling by removing activating K63 chains formed by TRAF2/6."
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"Under normal conditions, the ubiquitination of TRAF2 is suppressed by CYLD."
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"CYLD attenuates NF-κB activity by regulating the ubiquitination of NEMO, TRAF2, TRAF6, and TAK1, which are important signaling elements constituting the NF-κB pathway [ 16–18 ]."
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"Notably, CYLD physically interacts with and deubiquitinates TRAF2, an E3 ubiquitin–protein ligase that modifies itself with Lys63-linked ubiquitin chains."
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"CYLD knockout increases ubiquitination of TRAF2, leading to sustained JNK signaling, which subsequently upregulates cyclin D1 and c-Myc expression [46]."
35884607
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"For example, CYLD inhibits the ubiquitination of TRAF2 and NEMO to negatively regulate the activation of NF-κB by TLR and TNF signaling [58–60] ."
23415874
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"For instance, CYLD deubiquitinates the K63-Ub chains of TRAF2 and, to some extent, TRAF6, and inhibits NF-kappaB activity."
19392652
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"By deubiquitinating TRAF2/TRAF6, NF-κB essential modifier (NEMO), CYLD, acts as a key regulator in the typical p65/NF-κB pathway [19, 20]."
38907316
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"Because the target of CYLD in the NF-kappaB pathway is known to be deubiquitination of TRAF2, we also confirmed the deubiquitination of TRAF2 by CYLD in ECs."
18245814
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"To verify this hypothesis, we examined CYLDex7/8 -/- mice, which lack the full CYLD molecule but overexpress a shorter CYLD isoform (sCYLD) that is unable to bind to and thus deubiquitinate TRAF2."
25824820
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"Under normal conditions, CYLD dominantly suppresses the ubiquitination of TRAF2."
15870263
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"An example is CYLD which suppress the ubiquitination of TNF receptor associated factor 2 (TRAF2)."
23797609
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"Using an shRNA approach, Brummelkamp et al. showed that CYLD inhibits NF-kappaB signaling by counteracting TRAF2 ubiquitination [XREF_BIBR]."
21119682
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"Contributing to the " death signal ", CYLD deubiquitylates TRAF2 and RIPK1, allowing the formation of the ripoptosome."
| PMC
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"In this study, we also confirmed that CYLD deubiquitinated TRAF2, leading to inactivation of the NF-kappaB pathway in ECs, although CYLD may have other targets to suppress NF-kappaB activity."
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"CYLD mediated regulation of the JNK signaling pathway appears to target TRAF2 ubiquitylation, as CYLD knockdown increases both TRAF2 ubiquitylation and JNK activation, further enhancing cell survival [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
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"It is well established that CYLD interacts with TRAF2, causing deubiquitination of both TRAF2 and RIP1 44,47–50 and that activation of CYLD can block NF-κB activation induced by TNF-α stimulation."
16936264
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
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"Another protein, ubiquitin carboxyl-terminal hydrolase CYLD, deubiquitinates TRAF2 to block NF-κB activation [10] ."
26299341
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"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
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"Here we described that the adenoviral vector expressing CYLD (Ad/hTERT-CYLD) augmented the cytotoxicity of TRAIL in HCC cells by negatively regulating NF-kappaB activity since CYLD could reverse the ubiquitination of TNF receptor associated factor 2 (TRAF2) and interact with the IkappaB kinasegamma (IKKgamma)."
16627981
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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"CYLD is also responsible for deubiquitinating TRAF2 during necroptosis, stopping constitutive TRAF2 associated with MLKL [64]."
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"The steady state association of TRAF2 with MLKL was diminished upon TNF induced necroptosis induction, and this correlated with CYLD dependent deubiquitylation of TRAF2."
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