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CYLD deubiquitinates DVL. 4 / 4
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"Based on the established role of Wnt signaling in self-renewal of the skin, associated cell lineage decisions, and skin appendage formation (Fuchs, 2007), we propose that increased or prolonged activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Dvl is ubiquitinated by NEDL1, KLHL12, NEDD4L, Huwe1, Inversin, and ITCH and deubiquitinated by CYLD, USP9X, and USP14 (Miyazaki et al. 2004; Angers et al. 2006; Tauriello et al. 2010; Wei et al. 2012; Ding et al. 2013; Jung et al. 2013; de Groot et al. 2014; Nielsen et al. 2019)."

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"Knockout of CYLD in tumor cells can prevent K63 linked deubiquitination of Dvl [Dishevelled], which enhances Wnt and beta-catenin signaling [XREF_BIBR]."

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"It is also reported that a tumor suppressor CYLD deubiquitinase inhibits the ubiquitination of Dvl."