IndraLab

Statements

CYLD deubiquitinates IKK_complex. 5 / 5
| 5
reach
"Previous studies indicated that CYLD could act as a negative regulator of NF-κB signaling by deubiquitinating NF-κB essential modulator (NEMO), the subunit of IκB kinase (IKK), and tumor necrosis factor receptor-associated factor (TRAF) 2 and 6 [49,50]."
35884607
reach
"When transfected into mammalian cells, CYLD deubiquitinates NEMO as well as several IKK upstream regulators, including TRAF2, TRAF6, TRAF7, RIP1, and Tak1."
19373246
reach
"CYLD also deubiquitinates IkappaB kinase gamma (IKKgamma, also known as NEMO), the regulatory subunit of IKK thus inhibiting the activation of IKK."
19489724
reach
"CYLD also inhibits the ubiquitylation of TBK1 and IKKɛ, which contributes to the negative regulation of IFN responses ."
28959952
reach
"CYLD overexpression decreased RIG-I, TBK1, and IKKε ubiquitination [16]."
39158695