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CYLD deubiquitinates RIPK2. 3 / 3
1 | 2
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"The authors showed that CYLD deubiquitinated RIPK2 in macrophages infected with L. monocytogenes, leading to impaired activation of NF-kappaB, reduced production of proinflammatory cytokines and reactive oxygen and nitrogen species, which ultimately resulted in impaired infection control."
29520263
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"<span class="match term0">CYLD</span>-mediated K63 deubiquitination of <span class="match term1">RIPK2</span> resulted in an impaired activation of both NF-kappaB and ERK1/2 pathways, reduced production of proinflammatory cytokines interleukin-6 (IL-6), IL-12, anti-listerial reactive oxygen species (ROS) and nitric oxide (NO), and, finally, impaired pathogen control."
26834734
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"In addition, CYLD deubiquitinates STAT3 and RIPK2, thereby impairing protective IL-6 and NOD2-dependent protective immunity in listeriosis (37, 38)."
39958342