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CYLD deubiquitinates RIPK2. 2 / 3
1 | 2

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"The authors showed that CYLD deubiquitinated RIPK2 in macrophages infected with L. monocytogenes, leading to impaired activation of NF-kappaB, reduced production of proinflammatory cytokines and reactive oxygen and nitrogen species, which ultimately resulted in impaired infection control."

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"In addition, CYLD deubiquitinates STAT3 and RIPK2, thereby impairing protective IL-6 and NOD2-dependent protective immunity in listeriosis (37, 38)."