IndraLab

Statements

CYLD deubiquitinates NFkappaB. 7 / 7
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"In this investigation, we found that CYLD failed to inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination and NF-kappaB activation (XREF_FIG, XREF_SUPPLEMENTARY)."
21331078
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"In vivo, CYLD also reduced hepatic STAT3 K63 ubiquitination and activation, NF-kappaB activation, IL-6 and NOX2 mRNA production as well as fibrin production in murine listeriosis."
23825949
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"18 CYLD 's deubiquitination of NFkappaB inhibits NFkappaB activity without decreasing NFkappaB protein expression."
23034333
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"CYLD deubiquitinates several NF-kappaB regulators, including TRAF2, TRAF6, and NEMO as well as BCL3, a member of the NF-kappaB family of transcription factors."
19481526
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"CYLD deubiquitinates NEMO, thus decreasing its stability and preventing the IKK complex from phosphorylating IkappaB, and NF-kappaB activation."
28295216
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"Deubiquitination of NF-kappaB members by CYLD is crucial in controlling the magnitude and nature of cell activation."
19342479
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"Mechanistically, our results reveal that miR-135b directly targets the 3 '-untranslated region (UTR) of the deubiquitinase CYLD, thereby modulating ubiquitination and activation of NF-kappaB signaling."
33990540