IndraLab

Statements

CYLD deubiquitinates MAP3K7. 9 / 9
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"Although it is not yet clear precisely how CYLD regulates the function of the CARMA1-BCL-10-MALT1 signalosome, CYLD deubiquitylates TAK1 and thereby suppresses its catalytic activity 19."
18535581
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"These results indicate that USP4 mainly inhibits inducible TAK1 polyubiquitination and activation whereas CYLD mainly inhibits basal level of TAK1 polyubiquitination and activation."
21331078
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"Finally, we showed that CYLD interacts with and deubiquitinates TAK1 to negatively regulate the activation of the downstream MKK3/6-p 38alpha/beta pathway."
18332137
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"In this investigation, we found that CYLD failed to inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination and NF-kappaB activation (XREF_FIG, XREF_SUPPLEMENTARY)."
21331078
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"CYLD does not inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination."
21331078
ubibrowser
"The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.&CYLD targets a ubiquitin-dependent kinase, transforming growth factor-beta-activated kinase 1 (Tak1), and inhibits its ubiquitination and autoactivation."
22057290
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"Indeed, our data suggest that CYLD directly targets Tak1 and inhibits Tak1 ubiquitination."
17548520
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"Koga et al. had reported that CYLD interacted with and deubiquitinates TAK1 by negatively regulating the activation of the downstream MKK3/6-p 38alpha/beta pathway to resist the infection of gram positive bacterium Streptococcus pneumonia [XREF_BIBR]."
27738385
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"Inclusion of Cyld (WT) (XREF_FIG, lane3) but not Cyld (C601A) mutant (XREF_FIG, lane4) that lacks the DUB activity 37 resulted in diminished Tak1 ubiquitination suggesting that Cyld deubiquitinated Tak1."
22057290