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CYLD deubiquitinates MAP3K7. 16 / 18
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"CYLD abrogates TAK1 ubiquitination and autoactivation, leading to hyperactive TAK1, JNK, and IKK signaling in CLYD -deficient T cells [28] ."
23664135
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"These results indicate that USP4 mainly inhibits inducible TAK1 polyubiquitination and activation whereas CYLD mainly inhibits basal level of TAK1 polyubiquitination and activation."
21331078
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"In contrast, CYLD deficiency enhances IAV-induced RIG-I and TAK1 ubiquitination and innate antiviral immunity."
39158695
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"Indeed, our data suggest that CYLD directly targets Tak1 and inhibits Tak1 ubiquitination."
17548520
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"Although previous studies have suggested that CYLD deubiquitinates TAK1, the initiating event is unclear, that is to say, some signals may initiate the event."
31301291
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"Finally, we showed that CYLD interacts with and deubiquitinates TAK1 to negatively regulate the activation of the downstream MKK3/6-p 38alpha/beta pathway."
18332137
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"CYLD attenuates NF-κB activity by regulating the ubiquitination of NEMO, TRAF2, TRAF6, and TAK1, which are important signaling elements constituting the NF-κB pathway [ 16–18 ]."
35131382
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"Koga et al. had reported that CYLD interacted with and deubiquitinates TAK1 by negatively regulating the activation of the downstream MKK3/6-p 38alpha/beta pathway to resist the infection of gram positive bacterium Streptococcus pneumonia [XREF_BIBR]."
27738385
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"CYLD antagonizes antiviral immunity in part by deubiquitinating RIG-I and TAK1 [14]."
39158695
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"Furthermore, CYLD deubiquitylated mitogen-activated protein kinase kinase kinase 7 (TAK1), which negatively regulates TAK1-JNK-p38 signaling."
35884607
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"Although it is not yet clear precisely how CYLD regulates the function of the CARMA1-BCL-10-MALT1 signalosome, CYLD deubiquitylates TAK1 and thereby suppresses its catalytic activity 19."
18535581
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"These data suggest that CYLD is required for LRRC62-mediated inhibition of K63 linked poly-ubiquitination of TAK1.The results in Fig. 4 raised the possibility that LRRC62 recruits the CYLD to deubiqui[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31301291
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"CYLD does not inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination."
21331078
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"In this investigation, we found that CYLD failed to inhibit TAK1 and TAB1 co-overexpression-induced TAK1 polyubiquitination and NF-kappaB activation (XREF_FIG, XREF_SUPPLEMENTARY)."
21331078
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"Inclusion of Cyld (WT) (XREF_FIG, lane3) but not Cyld (C601A) mutant (XREF_FIG, lane4) that lacks the DUB activity 37 resulted in diminished Tak1 ubiquitination suggesting that Cyld deubiquitinated Tak1."
22057290
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"Consistent with these observations, our study showed that CYLD deficiency significantly enhanced TAK1 and RIG-I ubiquitination in IAV-infected cells (Fig. 9), leading to increased innate immunity."
39158695