IndraLab

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CYLD deubiquitinates ARHGEF12. 3 / 3
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"In the present study, we show that CYLD deubiquitinates LARG, thus adding LARG to the growing list of CYLD substrates."
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"Mechanistically, <span class="match term0">CYLD</span> does not interact with RhoA; instead, it interacts with and deubiquitinates leukemia-associated RhoGEF (<span class="match term1">LARG</span>)."
23405219
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"Taken together, our data provide the first evidence that CYLD deubiquitinates LARG and increases its ability to catalyze the GDP/GTP exchange on RhoA."
23405219