IndraLab

Statements

CYLD deubiquitinates ARHGEF12. 3 / 3
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"Mechanistically, CYLD does not interact with RhoA; instead, it interacts with and deubiquitinates leukemia-associated RhoGEF (LARG)."
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"In the present study, we show that CYLD deubiquitinates LARG, thus adding LARG to the growing list of CYLD substrates."
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"Taken together, our data provide the first evidence that CYLD deubiquitinates LARG and increases its ability to catalyze the GDP/GTP exchange on RhoA."
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