IndraLab

Statements

CYLD deubiquitinates IKBKG. 18 / 18
1 | 17
reach
"In contrast, CYLD can deubiquitinate the upstream regulatory factors of NF-κB, such as tumor necrosis factor receptor-associated factor (TRAF) 2, TRAF6, and NEMO 49-51, preventing excessive activation of NF-κB through negative feedback 52."
40083930
reach
"CYLD attenuates NF-κB activity by regulating the ubiquitination of NEMO, TRAF2, TRAF6, and TAK1, which are important signaling elements constituting the NF-κB pathway [ 16–18 ]."
35131382
reach
"CYLD deubiquitinates TRAF2, TRAF6 and NEMO, and inactivation of CYLD increases NF-ĸB signaling in a sustained manner, both in vitro and in vivo [43]."
39334439
reach
"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
reach
"CYLD also deubiquitinates IkappaB kinase gamma (IKKgamma, also known as NEMO), the regulatory subunit of IKK thus inhibiting the activation of IKK."
19489724
reach
"In the absence of any robust stimulation of NF-kappaB (such as TCR engagement or cytokine signaling), CYLD deubiquitylates TRAF2, TRAF6, and NEMO, dampening NF-kappaB signaling by removing activating K63 chains formed by TRAF2/6."
26732666
reach
"CYLD physically interacts with and deubiquitinates NEMO, thereby negatively regulating NF-kappaB activation [XREF_BIBR]."
18775672
reach
"CYLD, a protein encoded by a gene mutated in familial cylindromatosis (a pathology that affects hair follicles and eccrine glands), de-ubiquitinates TRAFs in addition to NEMO [11–13] ."
16857427
ubibrowser
"Other identified <span class="match term0">CYLD</span> substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (<span class="match term1">NEMO</span>), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
reach
"Deubiquitinating enzyme CYLD inhibits NEMO linear ubiquitination, possibly by disassembling both K63 linked and linear polyubiquitin."
21811235
reach
"Previous studies indicated that CYLD could act as a negative regulator of NF-κB signaling by deubiquitinating NF-κB essential modulator (NEMO), the subunit of IκB kinase (IKK), and tumor necrosis factor receptor-associated factor (TRAF) 2 and 6 [49,50]."
35884607
reach
"When transfected into mammalian cells, CYLD deubiquitinates NEMO as well as several IKK upstream regulators, including TRAF2, TRAF6, TRAF7, RIP1, and Tak1."
19373246
reach
"To confirm that Tax- or TRAF6 induced polyubiquitination of NEMO is blocked by CYLD expression, NEMO and an HA tagged ubiquitin mutant (HA-K63Ub) were co-expressed with Tax or TRAF6 in the presence or[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418100
reach
"CYLD deubiquitinates NEMO, thus decreasing its stability and preventing the IKK complex from phosphorylating IkappaB, and NF-kappaB activation."
28295216
reach
"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
reach
"For example, CYLD inhibits the ubiquitination of TRAF2 and NEMO to negatively regulate the activation of NF-κB by TLR and TNF signaling [58–60] ."
23415874
reach
"CYLD can deubiquitinate NEMO, preventing it from causing phosphorylation of IkB, thereby killing the signal [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25342597
reach
"CYLD deubiquitinates NEMO and prevents the phosphorylation of IκB and NF-κB activation [94]."
36613989