IndraLab

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CYLD deubiquitinates IKBKG. 11 / 11
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"To confirm that Tax- or TRAF6 induced polyubiquitination of NEMO is blocked by CYLD expression, NEMO and an HA tagged ubiquitin mutant (HA-K63Ub) were co-expressed with Tax or TRAF6 in the presence or[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17418100
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"When transfected into mammalian cells, CYLD deubiquitinates NEMO as well as several IKK upstream regulators, including TRAF2, TRAF6, TRAF7, RIP1, and Tak1."
19373246
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"Other identified CYLD substrates include TNF receptor associated factor 7 (TRAF7), TRAF interacting protein (TRIP), transforming growth factor beta-activated kinase 1 (TAK1), NF-kappa-B essential modifier (NEMO), lymphocyte cell specific protein-tyrosine kinase (LCK), receptor-interacting protein 1 (RIP1), retinoic acid inducible gene (RIG), and polo-like kinase 1 (PLK1)"
26763122
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"CYLD deubiquitinates NEMO, thus decreasing its stability and preventing the IKK complex from phosphorylating IkappaB, and NF-kappaB activation."
28295216
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"Deubiquitinating enzyme CYLD inhibits NEMO linear ubiquitination, possibly by disassembling both K63 linked and linear polyubiquitin."
21811235
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"Numerous studies in vitro and in vivo have validated that CYLD mediates NF-κB activation by deubiquitinating TRAF2, TRAF6, and NEMO, making it an important regulator in the adaptive immune response."
30285829
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"The Cylindroma tumour suppressor protein (CYLD) de-ubiquitinates NEMO and TRAF2 [XREF_BIBR - XREF_BIBR], while USP15 reverses betaTRCP mediated ubiquitination of IkappaBalpha [XREF_BIBR]."
22212761
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"CYLD also deubiquitinates IkappaB kinase gamma (IKKgamma, also known as NEMO), the regulatory subunit of IKK thus inhibiting the activation of IKK."
19489724
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"CYLD physically interacts with and deubiquitinates NEMO, thereby negatively regulating NF-kappaB activation [XREF_BIBR]."
18775672
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"CYLD can deubiquitinate NEMO, preventing it from causing phosphorylation of IkB, thereby killing the signal [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25342597
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"In the absence of any robust stimulation of NF-kappaB (such as TCR engagement or cytokine signaling), CYLD deubiquitylates TRAF2, TRAF6, and NEMO, dampening NF-kappaB signaling by removing activating K63 chains formed by TRAF2/6."
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