IndraLab

Statements

CYLD deubiquitinates TNF. 3 / 3
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"In addition, CYLD deubiquitinates components on complex I (including RIPK1) and is therefore required for TNF plus 5Z7-/Smac-/CHX-induced complex II formation and caspase-8 activation (Peltzer et al., 2016)."
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"The DUB function of CYLD was first revealed by in vitro work showing that CYLD inhibits the ubiquitination of certain TNF receptor associated factors and the regulatory subunit of IkappaB kinase."
17548520
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"Previous studies indicated that CYLD could act as a negative regulator of NF-κB signaling by deubiquitinating NF-κB essential modulator (NEMO), the subunit of IκB kinase (IKK), and tumor necrosis factor receptor-associated factor (TRAF) 2 and 6 [49,50]."
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