IndraLab

Statements

EIF3H is modified
9 | 37 3
EIF3H is phosphorylated.
9 | 35 3
EIF3H is phosphorylated. 10 / 36
| 34 2
sparser
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR-deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR/S6K1 pathway ( xref )."
28491073
sparser
"We therefore analyzed the levels of phosphorylation of eIF3H in the cervical cancer cell line HeLa."
22304650
sparser
"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
sparser
"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
sparser
"Among novel biochemical markers of brain damage neuroserpin may be a promising predictor of type 2 neurological complications and may express neuroregeneration after off-pump CABG, while glial fibrillary acidic protein, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 may not be suitable for this clinical setting."
31863758
sparser
"Serum concentrations of glial fibrillary acidic protein, neuroserpin, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 were evaluated at baseline, end of surgery as well as on postoperative day 1 and 7."
31863758
sparser
"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."
33659803
sparser
"Another possible plasma biomarker of CRCI is axonal phosphorylated neurofilament subunit H (pNF-H)."
34970595
sparser
"It is theoretically possible that eIF3h phosphorylation is a trigger for S6K1 departure from polysomes."
29281028
sparser
"The phytohormone auxin activates TOR kinase, promoting S6K1 phosphorylation at T449 and translation reinitiation of upstream open reading frame (uORF)-containing mRNAs via phosphorylation of eIF3h (eukaryotic initiation factor 3, subunit h) ( xref )."
25399018
EIF3H is phosphorylated on S183. 7 / 7
5 | 1 1
hprd
No evidence text available
20068231
hprd
No evidence text available
17322306
hprd
No evidence text available
18691976
hprd
No evidence text available
19651622
sparser
"This observation coincides with the critical in vivo effects of eIF3h’s ser-183 phosphorylation during malignant transformation of NIH 3T3 cells [ xref , xref ]."
24979134
rlimsp
"This oncogenic potential of eIF3h is enhanced by phosphorylation at Ser(183)."
18544531
hprd
No evidence text available
18767875
EIF3H is phosphorylated on T11. 1 / 1
1 |
hprd
No evidence text available
17924679
EIF3H is phosphorylated on S10. 1 / 1
1 |
hprd
No evidence text available
17924679
EIF3H is phosphorylated on T8. 1 / 1
1 |
hprd
No evidence text available
17924679
EIF3H is phosphorylated on S31. 1 / 1
1 |
hprd
No evidence text available
20068230
EIF3H is acetylated.
| 2
EIF3H is acetylated. 1 / 1
| 1
sparser
"In addition, immunoblot analysis showed that acetylation of histones H2B (K12 and K15) and H3K9 was not affected upon FR235222 treatment (), indicating that FR235222 specifically increases acetylation of the histone subunit H4."
19349466
EIF3H is acetylated on lysine. 1 / 1
| 1
sparser
"One of the most important histone post-translational modifications is acetylation of lysine residues of histone subunit H3."
20580849
METTL3 affects EIF3H
| 13 30
METTL3 binds EIF3H.
| 11 30
METTL3 binds EIF3H. 10 / 40
| 10 30
reach
"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."
34568001
sparser
"Mechanistically, exosomal circLPAR1 was internalized by CRC cells, and it suppressed tumor growth, likely because exosomal circLPAR1 directly bound with eIF3h specifically suppressed the METTL3-eIF3h interaction, decreasing the translation of oncogene BRD4."
35164758
sparser
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."
30232453
sparser
"In particular mRNA looping generated by METTL3-eIF3h interaction enhances translation of a large subset of oncogenic mRNAs, paving the way for the development of new cancer therapeutic strategies [ xref ]."
33202605
sparser
"In mammals, a direct functional and physical interaction between METTL3 and eIF3h supports the mRNA looping mechanism for ribosome recycling and translational control [ xref ], since eIF3 is essential for the attachment of the recycled 40S subunits to mRNA to start a new round [ xref , xref ]."
34070794
sparser
"In addition, direct physical and functional interactions between eIF3h and METTL3 have been reported to be required for enhanced translation of oncogenic mRNAs, formation of densely packed polyribosomes and oncogenic transformation of lung adenocarcinoma ( xref )."
36118041
sparser
"The METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes, and oncogenic transformation."
30232453
sparser
"This is supported by; 1) the position-dependent effects of METTL3 tethering on mRNA translation, 2) EM visualization of METTL3 bound to endogenous polyribosomes and its proximity to cap-binding proteins, 3) METTL3 interaction with eIF3h, and 4) Disruption of METTL3-eIF3h interaction abolishes the ability of METTL3 to promote translation, affect polysome conformation, or promote oncogenic transformation."
30232453
sparser
"For example, METTL3, METTL14 and WTAP compose a complex that promotes the localization of MTC at nuclear speckles [ xref ] and METTL3 interacts with eIF3h to enhance mRNA translation [ xref ]."
33808751
reach
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."
30232453
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
METTL3 activates EIF3H.
| 2
METTL3 activates EIF3H. 2 / 2
| 2
reach
"In addition, METTL3 can promote oncogene translation independently of m A readers by recruiting eIF3h."
31921660
reach
"METTL3 can promote cancer cell growth, survival, and invasion by recruiting eIF3h to the translation initiation complex and directly promotes oncogene translation independently of its MTase activity (34)."
31921660
EIF3H affects METTL3
| 12 30
EIF3H binds METTL3.
| 11 30
METTL3 binds EIF3H. 10 / 40
| 10 30
reach
"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."
34568001
sparser
"Mechanistically, exosomal circLPAR1 was internalized by CRC cells, and it suppressed tumor growth, likely because exosomal circLPAR1 directly bound with eIF3h specifically suppressed the METTL3-eIF3h interaction, decreasing the translation of oncogene BRD4."
35164758
sparser
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."
30232453
sparser
"In particular mRNA looping generated by METTL3-eIF3h interaction enhances translation of a large subset of oncogenic mRNAs, paving the way for the development of new cancer therapeutic strategies [ xref ]."
33202605
sparser
"In mammals, a direct functional and physical interaction between METTL3 and eIF3h supports the mRNA looping mechanism for ribosome recycling and translational control [ xref ], since eIF3 is essential for the attachment of the recycled 40S subunits to mRNA to start a new round [ xref , xref ]."
34070794
sparser
"In addition, direct physical and functional interactions between eIF3h and METTL3 have been reported to be required for enhanced translation of oncogenic mRNAs, formation of densely packed polyribosomes and oncogenic transformation of lung adenocarcinoma ( xref )."
36118041
sparser
"The METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes, and oncogenic transformation."
30232453
sparser
"This is supported by; 1) the position-dependent effects of METTL3 tethering on mRNA translation, 2) EM visualization of METTL3 bound to endogenous polyribosomes and its proximity to cap-binding proteins, 3) METTL3 interaction with eIF3h, and 4) Disruption of METTL3-eIF3h interaction abolishes the ability of METTL3 to promote translation, affect polysome conformation, or promote oncogenic transformation."
30232453
sparser
"For example, METTL3, METTL14 and WTAP compose a complex that promotes the localization of MTC at nuclear speckles [ xref ] and METTL3 interacts with eIF3h to enhance mRNA translation [ xref ]."
33808751
reach
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."
30232453
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
EIF3H inhibits METTL3.
| 1
EIF3H inhibits METTL3. 1 / 1
| 1
reach
"Knockdown of eIF3h suppressed the ability of METTL3 to promote cellular invasion (XREF_FIG and XREF_FIG)."
30232453
EIF3H affects EIF3E
7 | 2 22
EIF3H binds EIF3E. 10 / 24
7 | 2 15
sparser
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells 2004)."
20444226
biogrid
No evidence text available
22863883
reach
"In support of this, the association of the eIF3k : eIF3l dimer with eIF3 requires prior recruitment of eIF3e and eIF3h to the complex; knocking down eIF3h or eIF3e results in the strong and simultaneous downregulation of both eIF3k and l."
27924037
sparser
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
sparser
"In addition, the eIF3f subunit has been confirmed to interact with eIF3e and eIF3h ( xref )."
27703462
sparser
"EIF3e and eIF3h interact directly with each other in Arabidopsis (Kim et al., 2004)."
20444226
sparser
"Co‐expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (Figure 10)."
20444226
sparser
"EIF3e and eIF3h interact directly with each other in Arabidopsis ( xref )."
20444226
biogrid
No evidence text available
26344197
sparser
"AteIF3f protein interacts with Arabidopsis eIF3e and eIF3h in yeast."
20444226
EIF3H binds EIF3F and EIF3E. 5 / 5
| 5
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H affects SNAI1
| 22 1 6
EIF3H binds SNAI1.
| 12 1 1
SNAI1 binds EIF3H. 10 / 13
| 12 1
reach
"Next, immunoprecipitation of endogenous Snail from KYSE510 cells also confirmed the interaction between endogenous Snail and EIF3H."
32867821
reach
"EIF3H interacts with Snail."
32867821
reach
"To shed light on how EIF3H interacts with Snail, we further determined their cellular localization by immunofluorescence analysis."
32867821
sparser
"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."
32867821
reach
"We performed a co-IP assay combined with the mass spectrometry analysis and identified that an EMT associated transcription factor, Snail could interact with EIF3H."
32867821
reach
"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."
32867821
reach
"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."
32867821
reach
"Additional in vivo co-IP assay was performed in HEK293T and KYSE510 EIF3H-knockdown cells to test the specificity of the interaction between Snail and EIF3H."
32867821
reach
"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."
32867821
reach
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
SNAI1 binds EIF3H. 1 / 1
| 1
isi
"EIF3H interacts with Snail"
32867821
EIF3H increases the amount of SNAI1.
| 2 5
EIF3H increases the amount of SNAI1. 5 / 5
| 5
isi
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
isi
"Expression of Snail and EIF3H was detected (left) and the intensity of Snail expression was quantified by Image J software (right).cSnail-Flag, HA-UB plasmids with or without EIF3H were co-transfected in HEK293T cells for 24 h. After another 4 h 10 muM MG132 incubation, the ubiquitination assay was performed to detect the poly-ubiquitination of Snail.dandeThe CHX pulse-chase assay was performed on EIF3H stably overexpressed in KYSE150 and KYSE510 cells."
32867821
isi
"Clinically, the levels of EIF3H were positively correlated with Snail expression."
32867821
isi
"In concordance with our findings in xenograft model, the expression levels of EIF3H were positively correlated with Snail expression in the ESCC tissue samples (Fig.7c)."
32867821
isi
"The Snail and EIF3H expression were analyzed by immunoblotting (left panel)."
32867821
Modified EIF3H increases the amount of SNAI1. 1 / 1
| 1
reach
"XREF_FIG a, EIF3H expression increased Snail protein level."
32867821
EIF3H increases the amount of SNAI1. 1 / 1
| 1
reach
"The results exhibited that knockdown of EIF3H inhibited Snail protein level, and upregulated E-cadherin protein, whereas downregulated expression of N-Cadherin and Vimentin."
32867821
EIF3H deubiquitinates SNAI1.
| 4
EIF3H deubiquitinates SNAI1. 3 / 3
| 3
reach
"We observed overexpression of EIF3H deubiquitinated endogenous Snail, but knockdown of EIF3H facilitated ubiquitination of endogenous Snail."
32867821
reach
"Furthermore, we demonstrated Snail, as the novel identified substrate of EIF3H, could be deubiquitinated and stabilized by EIF3H."
32867821
reach
"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."
32867821
Modified EIF3H leads to the deubiquitination of SNAI1. 1 / 1
| 1
reach
"When co-expressed Snail-Flag with EIF3H in HEK293T cells, we found that Snail ubiquitination could be abolished by EIF3H overexpression."
32867821
EIF3H activates SNAI1.
| 3
EIF3H activates SNAI1. 3 / 3
| 3
reach
"We further validated whether EIF3H modulates Snail stability through deubiquitination."
32867821
reach
"EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability."
32867821
reach
"Results showed that EIF3H obviously upregulated the Snail protein, but did not affect the mRNA level of Snail."
32867821
EIF3H decreases the amount of SNAI1.
| 1
EIF3H decreases the amount of ubiquitinated SNAI1. 1 / 1
| 1
reach
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay."
32867821
EIF3H affects EIF3F
6 | 3 18
EIF3H binds EIF3F. 10 / 18
6 | 3 8
biogrid
No evidence text available
19615732
reach
"Meanwhile, knockdown EIF3F, which directly binds to EIF3H and could function as deubiquitinase, has no effect on YAP expression and cytosol and nuclear ratios (XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY)."
32269044
sparser
"To test whether eIF3f and eIF3h actually interact with the eIF4GI682-1130-MS2 fusion protein, we co-expressed both factors transiently in HEK 293T cells, immunoprecipitated the eIF4G core domain via its MS2 fusion in presence of RNase A and tested for its association of eIF3f and eIF3h ( xref )."
25148142
biogrid
No evidence text available
28514442
biogrid
No evidence text available
22939629
sparser
"Our results show that At eIF3f interacts with eIF3h."
20444226
biogrid
No evidence text available
19615732
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
sparser
"xDnd1 directly binds eIF3f and in IP experiments, brings down eIF3m and eIF3h, which associate with eIF3f ( xref )."
30230100
reach
"Based on the convincing fit of the eIF3a and eIF3c structure into the EM density, we attempted to dock the recently solved paralogs of eIF3e (CSN1) and the eIF3h and eIF3f heterodimer (Rpn8 and Rpn11) into the eIF3.IRES EM density along with older models for eIF3k, eIF3m, and eIF3l (XREF_FIG A)."
25171412
EIF3H binds EIF3F and EIF3E. 5 / 5
| 5
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
RNF139 binds EIF3H and EIF3F. 2 / 2
| 2
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
GNPTAB binds EIF3H and EIF3F. 1 / 1
| 1
sparser
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
reach
"The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H."
30022709
reach
"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."
29136179
reach
"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."
31423012
eidos
"Knockdown of EIF3H inhibited cell proliferation and colony formation ."
32867821
reach
"Previous studies have shown that RFFL and HDAC2 are known to also promote tumor formation by inhibiting the apoptosis process [XREF_BIBR, XREF_BIBR, XREF_BIBR], whereas EIF3H is known to increase cell proliferation, growth and survival and inhibit the apoptosis process [XREF_BIBR]."
24377043
reach
"EIF3H overexpression increases tumor cell proliferation, growth, and survival."
27340783
reach
"Finally, reduction of eIF3h levels in breast and prostate cancer cell lines by short interfering RNA methods reduces their rates of proliferation and anchorage independent growth in soft agar."
18544531
reach
"The higher polyp number associated with the C allele of rs16892766 could be explained by the location of this SNP in the EIF3H gene, which increases cell proliferation, growth, and survival when overexpressed."
26880076
reach
"Reduction of eIF3h levels in breast and prostate cancer cell lines by shRNA methods has previously been shown to reduce cell proliferation and anchorage independent growth in soft agar XREF_BIBR."
20862326
reach
"XREF_BIBR At the cellular level, EIF3H overexpression increases proliferation, growth and survival."
19204574
EIF3H inhibits cell population proliferation. 6 / 6
| 6
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
reach
"Knockdown of the translation initiation factor EIF3H, which scored as essential in 8 BrCa, 5 PDAC, and 3 HGS-OvCa cell lines, by any of three independent shRNAs significantly reduced cell proliferation in the HGS-OvCa cell lines tested (OVCAR5, OVCAR8 and A2780) (XREF_FIG)."
22585861
reach
"The in vitro results indicated that silencing EIF3H in MM cells could significantly suppress cell proliferation, promote cell apoptosis and induce cell cycle arrest."
33508274
reach
"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro, whereas depletion of EIF3H significantly reduced cell proliferation."
32867821
reach
"Knockdown of EIF3H significantly inhibited the proliferation and colony formation of OS cells in vitro, and tumour growth in nude mice in vivo."
29805516
reach
"EIF3H depletion in ESCC cells significantly decreased the ability of cell proliferation and mobility, examined by CCK8 assay, colony formation assay and transwell assay in vitro and xenograft and tail-vein lung metastatic mouse models in vivo."
32867821
EIF3H affects YAP1
| 1 21
EIF3H binds YAP1.
| 21
YAP1 binds EIF3H. 10 / 21
| 21
sparser
"In addition, the interaction between endogenous EIF3H and YAP in both cytosol and nucleus was further confirmed by confocal immunofluorescence and in situ Proximity Ligation Assay ( xref and xref )."
32269044
sparser
"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
sparser
"We further observed, while EIF3H cofractionated with EIF3A in peak I (Fraction 2-4), EIF3H cofractionated with YAP in peak II (Fraction 8-12), suggesting the presence of two endogenous EIF3H complexes, one eIF3 complex and another EIF3H-YAP complex."
32269044
sparser
"Mutated EIF3H catalytic core or disrupted EIF3H-YAP binding affect YAP expression independent on translation."
32269044
sparser
"These results implicated that mutated EIF3H catalytic core (EIF3H DDQ/AAA ) or disrupted EIF3H-YAP binding (EIF3H YW/AA ) has no effect on eIF3 complex integrity, YAP mRNA binds to eIF3 complex."
32269044
sparser
"The above analysis has indicated the importance of the N-terminal 14 amino acids on YAP and the amino acid stretch 34-146 on EIF3H in mediating the interaction between YAP and EIF3H. To further identify the pivotal amino acid residues in EIF3H responsible for recognition of YAP by EIF3H, we have further performed molecular docking simulations by homology modelling service iTASSER and Haddock ( xref – xref )."
32269044
sparser
"As shown in xref – xref , replacement of Trp119, Tyr140 alone or combine by alanines significantly destabilized EIF3H-binding to YAP, presumably due to the perturbation of the interfacial interactions between EIF3H and YAP ( xref ), and reduced the deubiquitylation capacity of EIF3H, which function same as the catalytic core mutant EIF3H DDQ/AAA ( xref )."
32269044
sparser
"Our blast analysis further suggests the potential role for the four conserved proline residues in this region that facilitate the interaction between YAP and EIF3H ( xref )."
32269044
sparser
"The identification of an interaction between EIF3H and YAP brings us a puzzle because EIF3H was previously thought as a member of the eIF3 complex involved in regulating protein translational initiation and elongation ( xref )."
32269044
sparser
"To our surprise, we observed, while only overexpression of the wild-type EIF3H fully recapitulates lung metastasis, the expression of mutant EIF3H fails to restore lung metastasis, indicating that EIF3H-YAP axis is critical for EIF3H-driven tumor invasion and metastasis ( xref and xref )."
32269044
EIF3H activates YAP1.
| 1
EIF3H activates YAP1. 1 / 1
| 1
eidos
"EIF3H catalyzed YAP for deubiquitylation , resulting in its stabilization ."
32269044
SNAI1 affects EIF3H
| 13 1 4
SNAI1 binds EIF3H.
| 12 1 1
SNAI1 binds EIF3H. 10 / 13
| 12 1
reach
"Next, immunoprecipitation of endogenous Snail from KYSE510 cells also confirmed the interaction between endogenous Snail and EIF3H."
32867821
reach
"EIF3H interacts with Snail."
32867821
reach
"To shed light on how EIF3H interacts with Snail, we further determined their cellular localization by immunofluorescence analysis."
32867821
sparser
"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."
32867821
reach
"We performed a co-IP assay combined with the mass spectrometry analysis and identified that an EMT associated transcription factor, Snail could interact with EIF3H."
32867821
reach
"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."
32867821
reach
"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."
32867821
reach
"Additional in vivo co-IP assay was performed in HEK293T and KYSE510 EIF3H-knockdown cells to test the specificity of the interaction between Snail and EIF3H."
32867821
reach
"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."
32867821
reach
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
SNAI1 binds EIF3H. 1 / 1
| 1
isi
"EIF3H interacts with Snail"
32867821
SNAI1 increases the amount of EIF3H.
| 3
SNAI1 increases the amount of EIF3H. 3 / 3
| 3
isi
"Expression of Snail and EIF3H was detected (left) and the intensity of Snail expression was quantified by Image J software (right).cSnail-Flag, HA-UB plasmids with or without EIF3H were co-transfected in HEK293T cells for 24 h. After another 4 h 10 muM MG132 incubation, the ubiquitination assay was performed to detect the poly-ubiquitination of Snail.dandeThe CHX pulse-chase assay was performed on EIF3H stably overexpressed in KYSE150 and KYSE510 cells."
32867821
isi
"In clinical ESCC samples, there is also a positive correlation between EIF3H and Snail expression."
32867821
isi
"Scale bars, 100 mum.cThe positive correlation was obtained in ESCC samples between EIF3H and Snail protein expression"
32867821
SNAI1 decreases the amount of EIF3H.
| 1
SNAI1 decreases the amount of EIF3H. 1 / 1
| 1
reach
"Knockdown of Snail strikingly reversed the promoting effects of ectopic expression of EIF3H."
32867821
EIF3H affects apoptotic process
| 14
EIF3H inhibits apoptotic process.
| 9
EIF3H inhibits apoptotic process. 9 / 10
| 9
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
reach
"As shown in XREF_FIG, EIF3H knockdown also increased the rate of apoptosis in the two OS cell lines based on flow cytometry using Annexin V and 7-AAD double staining at both the early and late phases of apoptosis (Saos2 cells : 14.13 and 3.83% vs. 4.97 and 0.67% in controls, respectively, P < 0.05; U2OS cells : 7.96 and 12.53% vs. 6.89 and 7.14% in controls, respectively, P < 0.01)."
29805516
reach
"Mahmood et al demonstrated that EIF3H knockdown with specific small interfering RNA induced cell cycle arrest and apoptosis in breast tumour cells."
29805516
reach
"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."
18544531
reach
"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."
31423012
reach
"Thus, we come to the conclusion that EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells at the same time by stabilizing the CCND1 protein structure."
36350008
reach
"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."
19204574
reach
"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."
27340783
reach
"The knockdown of EIF3H, TPPP3, or DOCK2 promoted apoptosis of stem cells."
33509274
EIF3H activates apoptotic process.
| 5
EIF3H activates apoptotic process. 5 / 5
| 5
reach
"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro."
35809300
reach
"In addition, we showed that EIF3H knock-down led to cell apoptosis."
30022709
reach
"Knockdown of EIF3H led to cell cycle arrest and promoted apoptosis in OS cells."
29805516
reach
"The in vitro results indicated that silencing EIF3H in MM cells could significantly suppress cell proliferation, promote cell apoptosis and induce cell cycle arrest."
33508274
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
EIF3H affects Neoplasm Metastasis
| 4 11
reach
"Besides, it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo."
32867821
reach
"Taken together, these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC."
32867821
reach
"To find out whether EIF3H enhances cancer metastasis ability in vivo, we then performed lung metastatic model assay."
32867821
reach
"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
32867821
reach
"In the spontaneous lung metastasis model, we observed that loss of EIF3H significantly decreased lung metastasis nodules."
32269044
eidos
"Other than the translation-initiation function of EIF3H , in the present study , our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation ."
32269044
eidos
"Besides , it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo ."
32867821
reach
"Thus, functional knockdown of EIF3H expression inhibits HCC growth and metastasis in vitro and in vivo."
27340783
eidos
"To find out whether EIF3H enhances cancer metastasis ability in vivo , we then performed lung metastatic model assay ."
32867821
eidos
"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."
32867821
EIF3H bound to PDCD4 activates Neoplasm Metastasis. 1 / 1
| 1
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
Mutated EIF3H activates Neoplasm Metastasis. 1 / 1
| 1
reach
"To our surprise, we observed, while only overexpression of the wild-type EIF3H fully recapitulates lung metastasis, the expression of mutant EIF3H fails to restore lung metastasis, indicating that EIF3H-YAP axis is critical for EIF3H driven tumor invasion and metastasis (XREF_FIG and XREF_SUPPLEMENTARY)."
32269044
GPHN affects EIF3H
| 6 6
GPHN binds EIF3H. 8 / 8
| 5 3
sparser
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
sparser
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non-neuronal cells and forms a complex with eIF3 in the brain."
20858277
sparser
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
reach
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non neuronal cells and forms a complex with eIF3 in the brain."
20858277
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
reach
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
reach
"We then examined the possibility that gephyrin may also interact with eIF3H."
20858277
GPHN binds EIF3H and CB. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects EIF3B
8 | 1 2
EIF3H binds EIF3B. 9 / 9
8 | 1
biogrid
No evidence text available
18599441
biogrid
No evidence text available
28514442
biogrid
No evidence text available
22939629
biogrid
No evidence text available
18628297
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
26186194
biogrid
No evidence text available
18599441
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26344197
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H binds EIF3D and EIF3B. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3H affects translation
| 10
EIF3H activates translation.
| 9
EIF3H activates translation. 9 / 9
| 9
reach
"These risk variants, conferring an approximate 10%-18% increase in risk per allele, are located either inside or near protein coding genes that include TFEB (lysosome biogenesis and autophagy), EIF3H (initiation of translation), CYP17A1 (steroidogenesis), SPSB2 (proteasome degradation), and RPS21 (ribosome biogenesis)."
26965516
reach
"Our results are in agreement with these ideas and suggest an eIF3H mediated control of HIF-1alpha translation that could explain in part its oncogenic properties."
25166596
reach
"In any case, polysomal microarray analysis clearly demonstrated that eIF3h is a general stimulator of efficient translation of short uORF (s)-containing mRNAs throughout the transcriptome."
29281028
reach
"In agreement with this, our data show that, as CCT is required for the correct folding of eIF3h and eIF3i subunits, it indirectly influences gene expression with eIF3i overexpression enhancing both cap- and IRES (internal ribosome entry segment)-dependent translation initiation, whereas eIF3h overexpression selectively increases IRES dependent translation initiation."
24320561
reach
"Together with the study which suggests that eIF3h may play an important regulatory role in translation of specific mRNAs [75] as discussed above, these findings suggest that aberrant over-expression o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16829125
reach
"Earlier studies found that the elevation of eIF3h could stimulate protein synthesis."
32708122
reach
"This is an important TOR effect, since the S6K pathway not only stimulates overall protein synthesis but also eIF3h mediated translation reinitiation after an upstream open reading frame (uORF), a frequent feature found in plant mRNAs."
28491073
reach
"Interestingly, the oncogenic function of METTL3 in NSCLC is complicated, where METTL3 could methylate YAP mRNA and recruit YTHDF1/3 and eIF3b to promote translation of YAP mRNA, or could interact with eIF3h to promote translation of target mRNAs (e.g., BRD4) independent of its enzymatic activity."
32183948
reach
"Translation assays revealed that eIF3h supports the efficient translation of the mRNAs for CLV1 and the leaf transcription factor, AS1, which contain uORFs in their 5 ' UTR."
24736281
EIF3H inhibits translation.
| 1
EIF3H inhibits translation. 1 / 1
| 1
reach
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."
30232453
EIF3H affects EIF3D
7 | 1 2
EIF3H binds EIF3D.
7 | 2
EIF3H binds EIF3D. 7 / 7
7 |
biogrid
No evidence text available
22190034
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H binds EIF3D and EIF3B. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3H inhibits EIF3D.
| 1
EIF3H inhibits EIF3D. 1 / 1
| 1
reach
"Depletion of eIF3d, but not eIF3e or eIF3h, reduced the inhibitory effect of SXL, suggesting that eIF3d is a potential target of the repressor complex within the translational machinery."
29635389
EIF3H affects EIF3A
9 | 1
EIF3A binds EIF3H. 9 / 9
9 |
biogrid
No evidence text available
14519125
biogrid
No evidence text available
17353931
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22863883
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28514442
biogrid
No evidence text available
9822659
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H activates Neoplasm Invasiveness.
| 8
reach
"We found that EIF3H overexpression significantly increased the abilities of migration and invasion in KYSE150 and KYSE510 cells."
32867821
reach
"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
32064160
reach
"Increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association XREF_BIBR."
25609216
reach
"We found that EIF3H is significantly upregulated in esophageal cancer and ectopic expression of EIF3H in ESCC cell lines promotes cell proliferation, colony formation, migration and invasion."
32867821
reach
"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
reach
"As shown in XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, knockdown of either the YAP and CTGF expression abrogated EIF3H driven tumor cell invasion."
32269044
reach
"We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association."
20862326
reach
"To further determine whether YAP is a physiologically relevant substrate for EIF3H that mediates EIF3H promoted tumor cell invasion, we have characterized catalytic function for EIF3H in regulating YAP abundance, YAP turnover rate and YAP ubiquitylation."
32269044
EIF3H inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
EIF3H affects EIF3C
6 | 2 1
EIF3H binds EIF3C. 8 / 8
6 | 2
biogrid
No evidence text available
22863883
biogrid
No evidence text available
26344197
reach
"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."
27703462
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3D affects EIF3H
7 | 2
EIF3H binds EIF3D. 7 / 7
7 |
biogrid
No evidence text available
22190034
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H binds EIF3D and EIF3B. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3C affects EIF3H
6 | 2 1
EIF3H binds EIF3C. 8 / 8
6 | 2
biogrid
No evidence text available
22863883
biogrid
No evidence text available
26344197
reach
"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."
27703462
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
RPS6KB1 affects EIF3H
1 | 5 2
RPS6KB1 phosphorylates EIF3H.
| 4 1
RPS6KB1 phosphorylates EIF3H. 4 / 4
| 3 1
reach
"S6K1 in turn phosphorylates the subunit h of eukaryotic Initiation Factor 3 (eIF3h), which promotes loading of mRNAs that carry upstream open reading frames (uORFs) within their 5' untranslated regions (5'UTRs) into the ribosome for translation re-initiation (Figure 1) (Schepetilnikov et al., 2013)."
32117365
reach
"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
sparser
"The previous report demonstrated EIF3H is regulated in response to mTOR-S6K1 cascade, where EIF3H can be phosphorylated by S6K1 kinase through the serine 183 on EIF3H ( xref )."
32269044
reach
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."
28491073
RPS6KB1 phosphorylates EIF3H on S183. 1 / 1
| 1
reach
"The previous report demonstrated EIF3H is regulated in response to mTOR-S6K1 cascade, where EIF3H can be phosphorylated by S6K1 kinase through the serine 183 on EIF3H."
32269044
RPS6KB1 binds EIF3H.
1 | 1 1
RPS6KB1 binds EIF3H. 3 / 3
1 | 1 1
biogrid
No evidence text available
16286006
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
sparser
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1 (Schepetilnikov et al. xref )."
29281028
PDCD4 affects EIF3H
1 | 1 5 1
PDCD4 binds EIF3H.
1 | 1 2 1
EIF3H binds PDCD4. 5 / 5
1 | 1 2 1
trips
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
sparser
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H. Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
reach
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H."
32064160
biogrid
No evidence text available
26344197
PDCD4 inhibits EIF3H.
| 2
PDCD4 inhibits EIF3H. 2 / 2
| 2
reach
"Furthermore, we discovered that introduction of PDCD4 to EIF3H overexpressing LUAD cells abrogated the function of EIF3H, reducing migration and invasion of LUAD cells by downregulating EMT signaling."
32064160
reach
"Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
PDCD4 activates EIF3H.
| 1
PDCD4 activates EIF3H. 1 / 1
| 1
reach
"Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
EIF3H affects CB
| 2 6
EIF3H binds CB. 4 / 4
| 4
sparser
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
sparser
"To investigate whether CB and eIF3H associate in a mammalian cell context, coimmunoprecipitation assays were carried out."
20858277
sparser
"Yeast-two-hybrid assay using the human CB lacking the SH3 domain (bait protein GAL4BD-CB SH3- ) showed that this truncated form of CB can also interact with eIF3H, indicating that this domain is not required to mediate the interaction with eIF3H (Figure xref )."
20858277
sparser
"Also, through YTH assay, we showed that the SH3 domain of CB is not required for interaction with eIF3H. Interaction of CB and eIF3H was further substantiated by coimmunoprecipitation of transiently expressed proteins in 293T cells."
20858277
EIF3H binds CB. 2 / 2
| 2
reach
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
GPHN binds EIF3H and CB. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
M affects EIF3H
4 | 3
EIF3H binds M. 3 / 3
3 |
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
EIF3H binds M. 3 / 3
| 3
reach
"We resorted to surface plasmon resonance assays to obtain further confirmation of a direct interaction between eIF3h and M, and to determine the characteristics of such an interaction."
17287294
reach
"This result allowed us to put forth the hypothesis that translation initiation on factor dependent mRNAs could be inhibited by RV M protein, by a mechanism that involves an interaction between M and eIF3h."
17287294
reach
"If it is the interaction between M and eIF3h that inhibits canonical initiation of protein synthesis, this inhibition should be overcome when the role of eIF3 in translation initiation is different."
17287294
EIF3H binds M. 1 / 1
1 |
virhostnet
No evidence text available
26789921
EIF3L affects EIF3H
6 | 1
EIF3L binds EIF3H. 6 / 6
6 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H affects M
4 | 3
EIF3H binds M. 3 / 3
3 |
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
EIF3H binds M. 3 / 3
| 3
reach
"We resorted to surface plasmon resonance assays to obtain further confirmation of a direct interaction between eIF3h and M, and to determine the characteristics of such an interaction."
17287294
reach
"This result allowed us to put forth the hypothesis that translation initiation on factor dependent mRNAs could be inhibited by RV M protein, by a mechanism that involves an interaction between M and eIF3h."
17287294
reach
"If it is the interaction between M and eIF3h that inhibits canonical initiation of protein synthesis, this inhibition should be overcome when the role of eIF3 in translation initiation is different."
17287294
EIF3H binds M. 1 / 1
1 |
virhostnet
No evidence text available
26789921
EIF3H affects EIF3L
6 | 1
EIF3L binds EIF3H. 6 / 6
6 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H affects EIF3G
6 1 |
EIF3H binds EIF3G. 7 / 7
6 1 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
hprd
No evidence text available
9822659
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
9822659
MYH9 affects EIF3H
| 6
EIF3H binds MYH9. 6 / 6
| 6
sparser
"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."
35113898
sparser
"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
EIF3M affects EIF3H
6 |
EIF3M binds EIF3H. 6 / 6
6 |
biogrid
No evidence text available
17403899
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
EIF3K affects EIF3H
5 1 |
EIF3K binds EIF3H. 6 / 6
5 1 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
hprd
No evidence text available
14519125
biogrid
No evidence text available
22939629
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
EIF3I affects EIF3H
4 | 1 1
EIF3I binds EIF3H. 5 / 5
4 | 1
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
reach
"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."
27210288
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3H affects MYH9
| 6
EIF3H binds MYH9. 6 / 6
| 6
sparser
"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."
35113898
sparser
"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
EIF3H affects EIF3M
6 |
EIF3M binds EIF3H. 6 / 6
6 |
biogrid
No evidence text available
17403899
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26344197
EIF3H affects EIF3K
5 1 |
EIF3K binds EIF3H. 6 / 6
5 1 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
hprd
No evidence text available
14519125
biogrid
No evidence text available
22939629
biogrid
No evidence text available
19615732
biogrid
No evidence text available
26186194
EIF3H affects EIF3I
4 | 1 1
EIF3I binds EIF3H. 5 / 5
4 | 1
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
reach
"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."
27210288
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3F affects EIF3E
| 6
EIF3H binds EIF3F and EIF3E. 5 / 5
| 5
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
RPL24 affects EIF3H
| 3 2
RPL24 binds EIF3H. 5 / 5
| 3 2
sparser
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
sparser
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
PTPRA affects EIF3H
| 5
EIF3H binds PTPRA. 5 / 5
| 5
sparser
"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."
24346161
sparser
"Wong et al. ( xref ) demonstrated that PtpA directly binds to the V1 subunit H to: i) block the trafficking of this subunit to the mycobacterial phagosome and ii) block its interaction with Vps33B ( xref )."
33717183
sparser
"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."
29709019
sparser
"PtpA binds subunit H of the V-ATPase (Wong et al., xref ) and it also binds to and dephosphorylates VPS33B (Bach et al., xref ), a protein enabling endosome to lysosome trafficking (Galmes et al., xref )."
33194845
sparser
"In a subsequent study from the same group, Wong et al. demonstrated that PtpA binds to subunit H of the host vacuolar ATPase (V-ATPase) in the phagosome membrane and that the macrophage class C sorting complex associates with the V-ATPase during phagosome maturation ( xref )."
25429354
EIF3H affects cell growth
| 5
EIF3H activates cell growth. 5 / 5
| 5
reach
"Overexpression of EIF3H promotes cancer cell growth [XREF_BIBR], results in a malignant phenotype [XREF_BIBR], and serves as a prognostic marker of recurrence and metastasis [XREF_BIBR, XREF_BIBR]."
32867821
reach
"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."
27340783
reach
"Overexpression of EIF3S3 promotes cancer cell growth."
16652384
reach
"50 Recent studies have shown that EIF3H promoted cancer cell growth by stimulating protein synthesis."
26965516
reach
"Besides, the mechanism of EIF3H mediated cell growth and migration also needs further study."
32867821
EIF3H affects RPL24
| 3 2
RPL24 binds EIF3H. 5 / 5
| 3 2
sparser
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
sparser
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
EIF3H affects PTPRA
| 5
EIF3H binds PTPRA. 5 / 5
| 5
sparser
"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."
24346161
sparser
"Wong et al. ( xref ) demonstrated that PtpA directly binds to the V1 subunit H to: i) block the trafficking of this subunit to the mycobacterial phagosome and ii) block its interaction with Vps33B ( xref )."
33717183
sparser
"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."
29709019
sparser
"PtpA binds subunit H of the V-ATPase (Wong et al., xref ) and it also binds to and dephosphorylates VPS33B (Bach et al., xref ), a protein enabling endosome to lysosome trafficking (Galmes et al., xref )."
33194845
sparser
"In a subsequent study from the same group, Wong et al. demonstrated that PtpA binds to subunit H of the host vacuolar ATPase (V-ATPase) in the phagosome membrane and that the macrophage class C sorting complex associates with the V-ATPase during phagosome maturation ( xref )."
25429354
EIF3H affects PDCD4
1 | 1 2 1
EIF3H binds PDCD4. 5 / 5
1 | 1 2 1
trips
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
sparser
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H. Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
reach
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H."
32064160
biogrid
No evidence text available
26344197
EIF3H affects AteIF3f
| 5
EIF3H binds AteIF3f. 5 / 5
| 5
reach
"Our results show that AteIF3f interacts with eIF3h."
20444226
reach
"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
reach
"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."
20444226
reach
"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
reach
"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
EIF3E affects EIF3F, and EIF3H
| 5
EIF3H binds EIF3F and EIF3E. 5 / 5
| 5
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
AteIF3f affects EIF3H
| 5
EIF3H binds AteIF3f. 5 / 5
| 5
reach
"Our results show that AteIF3f interacts with eIF3h."
20444226
reach
"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
reach
"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."
20444226
reach
"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
reach
"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
V ATPase I affects EIF3H
| 4
sparser
"Although the function of these importin domains is not known, it has been suggested that they might mediate the interaction of subunit H with other V-ATPase subunits or with other cellular proteins ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12788495
sparser
"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."
29019960
sparser
"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."
26999207
sparser
"Mtb PtpA can prevent phagosome-lysosome fusion by dephosphorylating host protein VPS33B, and prevent phagosome acidification by binding to subunit H of the macrophage V-ATPase complex to block V-ATPase trafficking xref , xref ."
28811474
reach
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin, while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology, loss of E-cadherin and accumulation of vimentin as well as fibronectin (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
reach
"A recent publication in lung adenocarcinoma demonstrated that EIF3H overexpression could also induce EMT signaling pathway [XREF_BIBR]."
32867821
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
EIF3H inhibits epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Knockdown of EIF3H inhibits the EMT process and cell mobility induced by Snail."
32867821
EIF3H affects V ATPase I
| 4
sparser
"Although the function of these importin domains is not known, it has been suggested that they might mediate the interaction of subunit H with other V-ATPase subunits or with other cellular proteins ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12788495
sparser
"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."
29019960
sparser
"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."
26999207
sparser
"Mtb PtpA can prevent phagosome-lysosome fusion by dephosphorylating host protein VPS33B, and prevent phagosome acidification by binding to subunit H of the macrophage V-ATPase complex to block V-ATPase trafficking xref , xref ."
28811474
EIF3H affects RPS6KB1
1 | 2 1
EIF3H binds RPS6KB1.
1 | 1 1
RPS6KB1 binds EIF3H. 3 / 3
1 | 1 1
biogrid
No evidence text available
16286006
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
sparser
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1 (Schepetilnikov et al. xref )."
29281028
EIF3H activates RPS6KB1.
| 1
EIF3H activates RPS6KB1. 1 / 1
| 1
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
EIF3H affects MYC
| 3 1
EIF3H inhibits MYC.
| 3
EIF3H inhibits MYC. 3 / 3
| 3
reach
"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."
19204574
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
reach
"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."
18544531
EIF3H binds MYC.
| 1
EIF3H binds MYC. 1 / 1
| 1
sparser
"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."
19204574
EIF3H affects DTrc8
| 4
EIF3H binds DTrc8.
| 3
EIF3H binds DTrc8. 3 / 3
| 3
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
EIF3H inhibits DTrc8.
| 1
EIF3H inhibits DTrc8. 1 / 1
| 1
reach
"Because downregulation of eIF3f or eIF3h suppresses DTrc8 induced growth inhibition in flies, we suspect these components form a bridge by which TRC8 affects its targets."
20068067
EIF3H affects DISC1
3 1 |
DISC1 binds EIF3H. 4 / 4
3 1 |
biogrid
No evidence text available
12812986
hprd
No evidence text available
12812986
biogrid
No evidence text available
17043677
biogrid
No evidence text available
12812986
EIF3H affects ABI3
3 1 |
ABI3 binds EIF3H. 4 / 4
3 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16189514
biogrid
No evidence text available
19060904
DISC1 affects EIF3H
3 1 |
DISC1 binds EIF3H. 4 / 4
3 1 |
biogrid
No evidence text available
12812986
hprd
No evidence text available
12812986
biogrid
No evidence text available
17043677
biogrid
No evidence text available
12812986
ABI3 affects EIF3H
3 1 |
ABI3 binds EIF3H. 4 / 4
3 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16189514
biogrid
No evidence text available
19060904
RNF139 affects EIF3H
| 1 2
RNF139 binds EIF3H and EIF3F. 2 / 2
| 2
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
RNF139 binds EIF3H. 1 / 1
| 1
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
23354061
PRRC2B affects EIF3H
3 |
PRRC2B binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
HIV1gp1 affects EIF3H
3 |
EIF3H binds HIV1gp1. 3 / 3
3 |
biogrid
No evidence text available
20016921
biogrid
No evidence text available
20016921
biogrid
No evidence text available
22190034
EIF3H affects hydrolysis
| 3
EIF3H inhibits hydrolysis. 3 / 3
| 3
sparser
"275, 21761-21767) showed that subunit H (part of the stator) inhibits ATP hydrolysis by free V1."
18156183
sparser
"Based upon the observed cross-linking between subunit H in the i peripheral stalk and subunit F in the central stalk in isolated V 1 , but not intact V 1 V 0 , it i was proposed that subunit H inhibited ATP hydrolysis by free V 1 by interacting with subunit F in the central rotor and preventing rotation [ xref ]."
26410601
sparser
"Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F."
18156183
EIF3H affects competence
| 3
EIF3H activates competence.
| 2
EIF3H activates competence. 2 / 2
| 2
reach
"In plants, eIF3 non core subunit h (eIF3h) greatly elevates the reinitiation competence of mRNAs coding for the Arabidopsis basic zipper transcription factors (bZIPs) and several ARFs; while the 60S ribosomal protein L24B (RPL24B), which is encoded by SHORT VALVE1, lifts translation of uORF containing mRNAs that encode ARF3 (ETTIN) and ARF5."
28659957
reach
"It was proposed that, by analogy with the function of yeast eIF3a and Tif32 discussed above, eIF3h (specifically its N-terminal part) might support efficient REI by preserving the competence of a fraction of uORF translating ribosomes to resume traversing downstream."
29281028
EIF3H increases the amount of competence.
| 1
EIF3H increases the amount of competence. 1 / 1
| 1
reach
"Besides, in plants, the eIF3h subunit helps to prevent the permanent loss of reinitiation competence, suggesting that this subunit might also be involved in tethering 40S to eIF4G."
21989405
EIF3H affects cell cycle
| 3
EIF3H inhibits cell cycle.
| 2
EIF3H inhibits cell cycle. 2 / 2
| 2
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
reach
"Mahmood et al demonstrated that EIF3H knockdown with specific small interfering RNA induced cell cycle arrest and apoptosis in breast tumour cells."
29805516
EIF3H activates cell cycle.
| 1
EIF3H activates cell cycle. 1 / 1
| 1
reach
"The in vitro results indicated that silencing EIF3H in MM cells could significantly suppress cell proliferation, promote cell apoptosis and induce cell cycle arrest."
33508274
EIF3H affects Snail protein
| 3
EIF3H activates Snail protein. 3 / 3
| 3
eidos
"As shown in Fig. 6a , EIF3H expression increased Snail protein level ."
32867821
eidos
"The results exhibited that knockdown of EIF3H inhibited Snail protein level , and upregulated E-cadherin protein , whereas downregulated expression of N-Cadherin and Vimentin ( Fig. 6b ) ."
32867821
eidos
"Results showed that EIF3H obviously upregulated the Snail protein , but did not affect the mRNA level of Snail ( Fig. 5a ) ."
32867821
EIF3H affects RNF139
| 1 2
RNF139 binds EIF3H and EIF3F. 2 / 2
| 2
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
RNF139 binds EIF3H. 1 / 1
| 1
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
23354061
EIF3H affects PRRC2B
3 |
PRRC2B binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
EIF3H affects HIV1gp1
3 |
EIF3H binds HIV1gp1. 3 / 3
3 |
biogrid
No evidence text available
20016921
biogrid
No evidence text available
20016921
biogrid
No evidence text available
22190034
EIF3H affects ESCC cells
| 3
EIF3H activates ESCC cells. 3 / 3
| 3
eidos
"* * * P < 0.001 ; NS : not significant EIF3H promotes Snail-mediated EMT in ESCC cells Considering that Snail is a pivotal EMT-related transcription factor [ 45 ] , we investigated the expression of Snail and EMT-related markers in EIF3H overexpression cells ."
32867821
eidos
"In summary , we demonstrated that EIF3H is responsible for tumorigenesis , tumor growth and metastasis of ESCC through stabilizing Snail , thus promoting the EMT phenotype in ESCC cells ."
32867821
eidos
"Collectively , these results indicate that EIF3H could promote Snail-mediated EMT in ESCC cells ."
32867821
EIF3H affects EIF3CL
3 |
EIF3CL binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
EIF3H affects ATPase activity
| 3
EIF3H inhibits ATPase activity.
| 2
EIF3H inhibits ATPase activity. 2 / 2
| 2
sparser
"This structure appears to be an inhibitory state wherein the subunit H inhibits the ATPase activity by stabilizing ADP binding to the catalytic site."
27807367
sparser
"Together with biochemical data, the structure supports a mechanistic model wherein subunit H inhibits ATPase activity by stabilizing an open catalytic site that results in tight binding of inhibitory ADP at another site."
27295975
EIF3H binds ATPase activity.
| 1
ATPase activity binds EIF3H. 1 / 1
| 1
sparser
"The structural similarity suggests how subunit H may interact with the ATPase itself or with other proteins."
11416198
EIF3CL affects EIF3H
3 |
EIF3CL binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, and EIF3J
3 |
EIF3J binds EIF3A, EIF3I, EIF3H, EIF3G, EIF3F, EIF3E, EIF3D, EIF3C, and EIF3B. 3 / 3
3 |
hprd
No evidence text available
9822659
hprd
No evidence text available
8995410
hprd
No evidence text available
8995409
DTrc8 affects EIF3H
| 3
EIF3H binds DTrc8. 3 / 3
| 3
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
Hsa-miR-939-3p affects EIF3H
2 |
Hsa-miR-939-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-873-3p affects EIF3H
2 |
Hsa-miR-873-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6888-3p affects EIF3H
2 |
Hsa-miR-6888-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6864-3p affects EIF3H
2 |
Hsa-miR-6864-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6860 affects EIF3H
2 |
Hsa-miR-6860 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6849-3p affects EIF3H
2 |
Hsa-miR-6849-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-661 affects EIF3H
2 |
Hsa-miR-661 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-612 affects EIF3H
2 |
Hsa-miR-612 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-548ah-5p affects EIF3H
2 |
Hsa-miR-548ah-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-520h affects EIF3H
2 |
Hsa-miR-520h decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-520g-3p affects EIF3H
2 |
Hsa-miR-520g-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-5189-5p affects EIF3H
2 |
Hsa-miR-5189-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-4522 affects EIF3H
2 |
Hsa-miR-4522 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3672 affects EIF3H
2 |
Hsa-miR-3672 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3664-5p affects EIF3H
2 |
Hsa-miR-3664-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3609 affects EIF3H
2 |
Hsa-miR-3609 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3187-5p affects EIF3H
2 |
Hsa-miR-3187-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3120-5p affects EIF3H
2 |
Hsa-miR-3120-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3065-5p affects EIF3H
2 |
Hsa-miR-3065-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-196a-3p affects EIF3H
2 |
Hsa-miR-196a-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1285-3p affects EIF3H
2 |
Hsa-miR-1285-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Collybistin affects EIF3H
| 2
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
Bisphenol A affects EIF3H
2 |
Bisphenol A increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
25181051
ctd
No evidence text available
30816183
Benzo[a]pyrene affects EIF3H
2 |
Benzo[a]pyrene increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
22228805
ctd
No evidence text available
21839799
RSPH9 affects EIF3H
2 |
RSPH9 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
RNF139 affects EIF3F
| 2
RNF139 binds EIF3H and EIF3F. 2 / 2
| 2
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
RNA-directed RNA polymerase NS5 affects EIF3H
2 |
RNA interference affects EIF3H
| 2
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
eidos
"We observed , while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines , including MDA-MB-231 , 4T1 , depletion of EIF3H by RNA interference largely attenuates tumor invasion ( Fig. 1B-F & Fig. S1A-C ) ."
32269044
N affects EIF3H
2 |
EIF3H binds N. 2 / 2
2 |
virhostnet
No evidence text available
17686838
virhostnet
No evidence text available
17686838
Membrane protein affects EIF3H
| 2
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [ xref , xref ]."
32455727
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [115,116]."
32455727
MTOR affects EIF3H
| 1 1
EIF3H binds MTOR. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
HNRNPA2B1 affects EIF3H
| 2
HNRNPA2B1 increases the amount of EIF3H.
| 1
HNRNPA2B1 increases the amount of EIF3H. 1 / 1
| 1
reach
"These data indicated that hnRNP A2B1 promoted the expressions of EIF3H, TPPP3, and DOCK2 and inhibited the expressions of DAPK1, SYT7, and RNF128 in melanoma stem cells."
33509274
HNRNPA2B1 binds EIF3H.
| 1
reach
"The analysis of the eCLIP (cross linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project (https://www.encodeproject.org) using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
HERC2 affects EIF3H
2 |
EIF3H binds HERC2. 2 / 2
2 |
biogrid
No evidence text available
25476789
biogrid
No evidence text available
25476789
GPHN affects CB
| 2
GPHN binds EIF3H and CB. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
EIF6 affects EIF3H
| 2
EIF3H binds EIF6. 2 / 2
| 2
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
reach
"As shown in XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H governed YAP accumulation but no effect for EIF3H and EIF3A binding."
32269044
EIF4G1 affects EIF3H
1 | 1
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
EIF3H binds EIF4G1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H bound to SNP rs16888589 inhibits transcription, DNA-templated. 1 / 1
| 1
reach
"Pittman et al showed that SNP rs16888589 at 8q23.3 bind EIF3H promoter and repressed its transcription XREF_BIBR."
22879968
EIF3H activates transcription, DNA-templated. 1 / 1
| 1
reach
"Translation assays revealed that eIF3h supports the efficient translation of the mRNAs for CLV1 and the leaf transcription factor, AS1, which contain uORFs in their 5 ' UTR."
24736281
EIF3H affects poly-ubiquitin
| 2
EIF3H decreases the amount of poly-ubiquitin.
| 1
EIF3H decreases the amount of poly-ubiquitin. 1 / 1
| 1
reach
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay."
32867821
EIF3H activates poly-ubiquitin.
| 1
reach
"Thus, Trp119 and Tyr140 on EIF3H are critical to ensuring the EIF3H mediated removal of YAP poly-ubiquitin conjugates."
32269044
EIF3H affects collybistin
| 2
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects cell migration
| 2
EIF3H inhibits cell migration.
| 1
EIF3H inhibits cell migration. 1 / 1
| 1
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
EIF3H activates cell migration.
| 1
EIF3H activates cell migration. 1 / 1
| 1
reach
"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
32064160
EIF3H affects SXL
| 1 1
EIF3H binds SXL.
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3H activates SXL.
| 1
EIF3H activates SXL. 1 / 1
| 1
reach
"Depletion of eIF3d, but not eIF3e or eIF3h, reduced the inhibitory effect of SXL, suggesting that eIF3d is a potential target of the repressor complex within the translational machinery."
29635389
EIF3H affects RSPH9
2 |
RSPH9 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
EIF3H affects RNA-directed RNA polymerase NS5
2 |
EIF3H affects N
2 |
EIF3H binds N. 2 / 2
2 |
virhostnet
No evidence text available
17686838
virhostnet
No evidence text available
17686838
EIF3H affects Membrane protein
| 2
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [ xref , xref ]."
32455727
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [115,116]."
32455727
EIF3H affects MTOR
| 1 1
EIF3H binds MTOR. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
EIF3H affects MAPK
| 2
EIF3H activates MAPK. 2 / 2
| 2
reach
"Zhu and colleagues identified that the transforming growth factor-beta and mitogen activated protein kinase pathways are potentially targeted by EIF3H using microarray analysis."
29805516
reach
"TGF-betaand MAPK pathways are potentially targeted by EIF3H."
27340783
EIF3H affects HIF1A
| 2
EIF3H decreases the amount of HIF1A.
| 1
EIF3H decreases the amount of HIF1A. 1 / 1
| 1
reach
"Indeed, we demonstrate in Fig. 5E -F that not only does inhibition of eIF3H via RNAi decrease CPEB2B mediated HIF1alpha expression, but that this mechanism is likely due to translation as demonstrated in Fig. 5F, S4."
| DOI
EIF3H activates HIF1A.
| 1
EIF3H activates HIF1A. 1 / 1
| 1
reach
"Our results are in agreement with these ideas and suggest an eIF3H mediated control of HIF-1alpha translation that could explain in part its oncogenic properties."
25166596
EIF3H affects HERC2
2 |
EIF3H binds HERC2. 2 / 2
2 |
biogrid
No evidence text available
25476789
biogrid
No evidence text available
25476789
EIF3H affects FN1
| 1 1
EIF3H activates FN1. 2 / 2
| 1 1
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
reach
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin, while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology, loss of E-cadherin and accumulation of vimentin as well as fibronectin (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
EIF3H affects EIF6
| 2
EIF3H binds EIF6. 2 / 2
| 2
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
reach
"As shown in XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H governed YAP accumulation but no effect for EIF3H and EIF3A binding."
32269044
EIF3H affects EIF4G1
1 | 1
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
EIF3H binds EIF4G1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects EIF3H
| 2
EIF3H inhibits EIF3H.
| 1
EIF3H inhibits EIF3H. 1 / 1
| 1
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
EIF3H activates EIF3H.
| 1
EIF3H activates EIF3H. 1 / 1
| 1
reach
"The expression of EIF3H is upregulated in HCC tissues compared with paired non tumor tissues from the same donor, thus linking upregulation of EIF3H to pathological hepatic changes."
27340783
EIF3H affects CSNK2A1
2 |
CSNK2A1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
EIF3H affects CCDC85B
1 1 |
CCDC85B binds EIF3H. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
EIF3F affects RNF139
| 2
RNF139 binds EIF3H and EIF3F. 2 / 2
| 2
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
CSNK2A1 affects EIF3H
2 |
CSNK2A1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
19615732
COPS8 binds EIF3A, EIF3H, EIF3E, EIF3C, EIF3B, and CSN7 subfamily. 2 / 2
| 2
sparser
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 ( xref )."
20444226
sparser
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim et al., 2004)."
20444226
COPS5 affects EIF3H
1 | 1
COPS5 inhibits EIF3H.
| 1
COPS5 inhibits EIF3H. 1 / 1
| 1
reach
"Reducing the copy number of eIF3f or eIF3h reduced the growth inhibitory phenotype of DTrc8 over-expression, much like reduction of the COP9 signalosome subunits, CSN5 and 6."
20068067
COPS5 binds EIF3H.
1 |
COPS5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
CCT_complex affects EIF3H
| 1 1
CCT_complex binds EIF3H.
| 1
CCT_complex binds EIF3H. 1 / 1
| 1
sparser
"We also identified eIF3h as a regulator of dendrite development ( xref ), although how CCT interacts with eIF3h in dendrites awaits further study."
33100975
CCT_complex activates EIF3H.
| 1
CCT_complex activates EIF3H. 1 / 1
| 1
reach
"In the present study, we show that the eukaryotic cytosolic chaperonin CCT [chaperonin containing TCP-1 (tailless complex polypeptide 1)] binds to newly synthesized eIF3b and promotes the correct folding of eIF3h and eIF3i."
24320561
CCDC85B affects EIF3H
1 1 |
CCDC85B binds EIF3H. 2 / 2
1 1 |
biogrid
No evidence text available
16189514
hprd
No evidence text available
16189514
CB affects GPHN
| 2
GPHN binds EIF3H and CB. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
A2B1 affects EIF3H
| 2
A2B1 activates EIF3H. 2 / 2
| 2
reach
"On the other hand, the hnRNP A2B1 overexpression resulted in significant upregulations of TPPP3, EIF3H, and DOCK2 and downregulations of DAPK1, RNF128, and SYT7 in melanoma stem cells."
33509274
reach
"Our findings revealed that the hnRNP A2B1 mediated splicing triggered the upregulation of TPPP3, DOCK2, and EIF3H, and the downregulation of RNF128, DAPK1, and SYT7 in melanoma stem cells, leading to the suppression of apoptosis of cancer stem cells."
33509274
5-fluorouracil affects EIF3H
2 |
5-fluorouracil increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
15585135
ctd
No evidence text available
16803524
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3H.
1 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3H.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21215274
17alpha-ethynylestradiol increases the amount of EIF3H.
1 |
17alpha-ethynylestradiol increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
17942748
17alpha-ethynylestradiol decreases the amount of EIF3H.
1 |
17alpha-ethynylestradiol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
23129252
Vorinostat affects EIF3H
| 1
Vorinostat activates EIF3H. 1 / 1
| 1
reach
"Moreover, when eIF3H silenced cells were treated with SAHA, we observed a further reduction in HIF-1alpha expression relative to that seen with either treatment alone (XREF_FIG), suggesting that SAHA and sieIF3H target HIF-1alpha via parallel pathways."
25166596
Vinclozolin affects EIF3H
1 |
Vinclozolin decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
23034163
Sunitinib affects EIF3H
1 |
Sunitinib increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31533062
Serpentine asbestos increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21148743
Rs16888589 risk region affects EIF3H
| 1
EIF3H binds rs16888589 risk region. 1 / 1
| 1
reach
"Thus, the rs16888589 risk region physically interacts with EIF3H."
20862326
Pregnenolone 16alpha-carbonitrile increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
28903501
Polyphenol affects EIF3H
1 |
Polyphenol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
16293270
Pic affects SXL
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
Perfluorooctanoic acid increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18804290
Nickel subsulfide affects EIF3H
1 |
Nickel subsulfide decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21086188
Methyltestosterone decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29191790
Methylparaben affects EIF3H
1 |
Methylparaben decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31745603
Methylmercury compound decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
26558463
Methylmercury chloride decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
28001369
Ketone body affects EIF3H
1 |
Ketone body increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
16807920
Hsa-miR-6830-3p affects EIF3H
1 |
Hsa-miR-6830-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5582-5p affects EIF3H
1 |
Hsa-miR-5582-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-5571-5p affects EIF3H
1 |
Hsa-miR-5571-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-511-5p affects EIF3H
1 |
Hsa-miR-511-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4423-3p affects EIF3H
1 |
Hsa-miR-4423-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-3622a-5p affects EIF3H
1 |
Hsa-miR-3622a-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-3613-3p affects EIF3H
1 |
Hsa-miR-3613-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-302d-5p affects EIF3H
1 |
Hsa-miR-302d-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-302b-5p affects EIF3H
1 |
Hsa-miR-302b-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-16-5p affects EIF3H
1 |
Hsa-miR-16-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668040
HnRNP affects EIF3H
| 1
EIF3H binds hnRNP. 1 / 1
| 1
sparser
"The analysis of the eCLIP (cross-linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project () using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
Hexabromocyclododecane decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29177809
Gentamycin affects EIF3H
1 |
Gentamycin increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
22061828
Gefitinib affects EIF3H
| 1
Gefitinib activates EIF3H. 1 / 1
| 1
reach
"Based on these premises, we evaluated MYC and EIF3H gene status in patients with NSCLC treated with the EGFR-TKI gefitinib."
19204574
EL24 affects EIF3H
| 1
EIF3H binds eL24. 1 / 1
| 1
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
EIF3kl dimer affects EIF3H
| 1
EIF3H binds eIF3kl dimer. 1 / 1
| 1
reach
"Affinity purification of N-terminally tagged eIF3k in the absence of eIF3h (strain DeltaeIF3hk, + N-k) yielded an eIF3kl dimer (XREF_FIG) indicating that eIF3k and l are either pre-assembled as a dimer and interact with eIF3 already containing the h subunit or alternatively the eIF3kl dimer binds to eIF3h and assembles with eIF3 as a trimer."
24250809
Doxorubicin affects EIF3H
1 |
Doxorubicin increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29803840
Disodium selenite affects EIF3H
1 |
Disodium selenite increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18175754
Dibutyl phthalate affects EIF3H
1 |
Dibutyl phthalate increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21266533
Cyclosporin A affects EIF3H
1 |
Cyclosporin A increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
25562108
Collybistin affects MTOR
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
Collybistin affects GPHN
| 1
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
Cas9 affects EIF3H
| 1
Cas9 activates EIF3H. 1 / 1
| 1
reach
"Hap1 cells were genetically modified with a construct encoding S. pyogenes Cas9 protein and guide strand construct targeting exon 1 of eIF3H."
29136179
Cadmium dichloride increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18804290
Aflatoxin B2 affects EIF3H
1 |
Aflatoxin B2 demethylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
30157460
YTHDF2 affects EIF3H
1 |
YTHDF2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
XPO1 affects EIF3H
1 |
XPO1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26673895
WDR48 affects EIF3H
1 |
WDR48 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
Vehicle Emissions affects EIF3H
1 |
Vehicle Emissions methylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
25560391
UTP23 affects EIF3H
| 1
UTP23 binds EIF3H. 1 / 1
| 1
sparser
"Top SNPs for the hyperthymic temperament were also involved in chromatin interactions in neural progenitor cells with EIF3S3:UTP23 in GSE87112 database (Supplementary Table S xref )."
34075027
USP3 affects EIF3H
1 |
USP3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
UNK affects EIF3H
1 |
UNK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25737280
UBC affects EIF3H
1 |
UBC binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16196087
Trp119 affects EIF3H
| 1
EIF3H binds Trp119. 1 / 1
| 1
isi
"Trp119 and Tyr 140 on EIF3H directly interacted with the N-terminal region of YAP1, facilitating complex formation of EIF3H and YAP1 for YAP1 deubiquitylation."
32269044
TOR affects EIF3H
| 1
TOR phosphorylates EIF3H. 1 / 1
| 1
reach
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."
28491073
TMEM203 affects EIF3H
1 |
TMEM203 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
TARDBP affects EIF3H
1 |
TARDBP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20020773
TADA2A affects EIF3H
1 |
TADA2A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20508642
Snail.EIF3H affects EIF3H
| 1
EIF3H binds Snail.EIF3H. 1 / 1
| 1
isi
"These results revealed the interaction between EIF3H and Snail mediated by the S-P rich domain of Snail.EIF3H interacts with Snail.aVector or EIF3H-Flag plasmid was transfected in HEK293T cells for 24 h. After a 4 h treatment of 10 muM MG132, cell lysate was immunoprecipitated with anti-FLAG M2 beads, and the proteins interact with EIF3H were analyzed by mass spectrometry."
32867821
SXL affects pic
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
SRRM2 affects EIF3H
1 |
SRRM2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
SRRM1 affects EIF3H
1 |
SRRM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
SPTBN1 affects EIF3H
1 |
SPTBN1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21866423
SORBS3 affects EIF3H
1 |
SORBS3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25416956
SOD1 affects EIF3H
1 |
SOD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29128334
SNP rs16888589 affects EIF3H
| 1
EIF3H binds SNP rs16888589. 1 / 1
| 1
reach
"Pittman et al showed that SNP rs16888589 at 8q23.3 bind EIF3H promoter and repressed its transcription XREF_BIBR."
22879968
SNAP-eIF3h affects EIF3H
| 1
Modified SNAP-eIF3h decreases the amount of EIF3H. 1 / 1
| 1
reach
"SNAP-eIF3h expresses at near wild-type levels via comparison with the loading control (nuclear matrix protein p84), and we further noted that SNAP-eIF3h overexpression diminishes endogenous levels of eIF3h in wild-type cells."
29136179
SNAP-eIF3H affects EIF3H
| 1
Modified SNAP-eIF3H decreases the amount of EIF3H. 1 / 1
| 1
reach
"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."
29136179
SMURF1 affects EIF3H
1 |
SMURF1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23184937
SFN affects EIF3H
1 |
SFN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17361185
RPS9 affects EIF3H
1 |
RPS9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
RPS20 affects EIF3H
1 |
RPS20 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
RP23-244N6.4 affects EIF3H
1 |
EIF3H binds RP23-244N6.4. 1 / 1
1 |
biogrid
No evidence text available
26496610
RP23-151A15.2 affects EIF3H
1 |
EIF3H binds RP23-151A15.2. 1 / 1
1 |
biogrid
No evidence text available
26496610
RP23-12I13.1 affects EIF3H
1 |
EIF3H binds RP23-12I13.1. 1 / 1
1 |
biogrid
No evidence text available
26549023
RFP affects EIF3H
| 1
EIF3H binds RFP. 1 / 1
| 1
sparser
"The data showed that the signal of GFP-tagged OsMTA2 (OsMTA2-GFP) was diffusely distributed in both nucleus and cytoplasm ( xref A) and indeed largely overlapped with eIF3h-RFP signal ( xref A)."
34070794
Q77M19 affects EIF3H
1 |
EIF3H binds Q77M19. 1 / 1
1 |
virhostnet
No evidence text available
21911578
PSMD12 affects EIF3H
1 |
EIF3H binds PSMD12. 1 / 1
1 |
biogrid
No evidence text available
28514442
PSEN1 affects EIF3H
| 1
EIF3H binds PSEN1. 1 / 1
| 1
sparser
"In comparison with the rat V-ATPase structure ( xref ), our human V-ATPase structure contains the essential subunit H, which interacts extensively with PS-1 and a-NTD ( xref and xref – xref )."
33065002
PPFIA1 affects EIF3H
| 1
EIF3H binds PPFIA1. 1 / 1
| 1
sparser
"Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPase) machinery, a multisubunit protein complex in the phagosome membrane that drives luminal acidification."
22087003
PAXIP1 affects EIF3H
1 |
EIF3H binds PAXIP1. 1 / 1
1 |
biogrid
No evidence text available
22990118
PAN2 affects EIF3H
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
NUP214 affects EIF3H
| 1
EIF3H binds NUP214. 1 / 1
| 1
reach
"Rabies virus (RV) matrix protein can interact with eIF3h to inhibit the expression of cellular genes."
29173589
NUMA1 affects EIF3H
1 |
EIF3H binds NUMA1. 1 / 1
1 |
biogrid
No evidence text available
26344197
NTS affects EIF3H
| 1
EIF3H binds NTS. 1 / 1
| 1
sparser
"Especially the interaction between V 1 and a NT peptides is interesting as these interactions suggest that binding of cytoplasmic V 1 to V o in the vacuole may be initiated by binding of subunit H to a NT as illustrated in xref ."
23071676
NTRK1 affects EIF3H
1 |
EIF3H binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NP_789740 affects EIF3H
1 |
EIF3H binds NP_789740. 1 / 1
1 |
virhostnet
No evidence text available
22190034
NP_705926 affects EIF3H
1 |
EIF3H binds NP_705926. 1 / 1
1 |
virhostnet
No evidence text available
22190034
NPM1 affects EIF3H
1 |
EIF3H binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23402259
NP affects EIF3H
1 |
EIF3H binds NP. 1 / 1
1 |
virhostnet
No evidence text available
25464832
NOX1 affects EIF3H
| 1
EIF3H binds NOX1. 1 / 1
| 1
sparser
"The heme moiety of the sGC in its reduced iron (Fe 2+ ) state is bound to the β subunit H-NOX domain through the axial ligand histidine 105 (His 105), building a penta-coordinate hystidyl–heme complex."
32046325
NCK2 affects EIF3H
1 |
EIF3H binds NCK2. 1 / 1
1 |
biogrid
No evidence text available
25416956
NAP1L1 affects EIF3H
1 |
EIF3H binds NAP1L1. 1 / 1
1 |
biogrid
No evidence text available
26344197
NA affects EIF3H
1 |
EIF3H binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
N-nitrosomorpholine increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
19716841
N-methyl-4-phenylpyridinium decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
26558463
MYOM2 affects EIF3H
| 1
EIF3H binds MYOM2. 1 / 1
| 1
reach
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [115,116]."
32455727
MYC affects EIF3H
| 1
EIF3H binds MYC. 1 / 1
| 1
sparser
"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."
19204574
MTREX affects EIF3H
1 |
MTREX binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
MTOR affects collybistin
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
MLN7243 affects EIF3H
1 |
MLN7243 sumoylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
31285264
MGMT affects EIF3H
1 |
EIF3H binds MGMT. 1 / 1
1 |
biogrid
No evidence text available
16226712
METTL3 affects 6 A
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
LIMA1 affects EIF3H
1 |
LIMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
IGSF8 affects EIF3H
1 |
IGSF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
ICAM1 affects EIF3H
1 |
EIF3H binds ICAM1. 1 / 1
1 |
biogrid
No evidence text available
23463506
HSP90AB1 affects EIF3H
1 |
EIF3H binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
16263121
HSP90AA1 affects EIF3H
1 |
EIF3H binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
16263121
HNRNPA1 affects EIF3H
1 |
EIF3H binds HNRNPA1. 1 / 1
1 |
biogrid
No evidence text available
25324306
HNRNP affects EIF3H
| 1
EIF3H binds HNRNP and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
HECW2 affects EIF3H
1 |
HECW2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24163370
GPHN affects collybistin
| 1
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
GPHN affects 293T
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
GPBP1L1 affects EIF3H
1 |
GPBP1L1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28514442
GNPTAB affects EIF3H
| 1
GNPTAB binds EIF3H and EIF3F. 1 / 1
| 1
sparser
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
GABPB2 affects EIF3H
1 |
GABPB2 decreases the amount of EIF3H. 1 / 1
1 |
biopax:msigdb
No evidence text available
GABPA affects EIF3H
1 |
GABPA decreases the amount of EIF3H. 1 / 1
1 |
biopax:msigdb
No evidence text available
G3BP1 affects EIF3H
1 |
G3BP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26777405
Eif3a affects EIF3H
| 1
Eif3a increases the amount of EIF3H. 1 / 1
| 1
reach
"Thus, it would be essential to investigate if EIF3H overexpression might go along and is driven by an additional overexpression of an EIF3 member of module I."
27340783
ELK1 affects EIF3H
1 |
ELK1 decreases the amount of EIF3H. 1 / 1
1 |
biopax:msigdb
No evidence text available
EIF4G3 affects EIF3H
1 |
EIF3H binds EIF4G3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF4G1 affects EIF3F
| 1
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
EIF4G affects EIF3H
| 1
EIF4G binds EIF3H. 1 / 1
| 1
reach
"One possibility to explain the interaction of eIF4G and eIF3h with the SUMO protease Ulp2 is that they are themselves modified by SUMO."
24818994
EIF4A2 affects EIF3H
1 |
EIF3H binds EIF4A2. 1 / 1
1 |
biogrid
No evidence text available
17353931
EIF4A1 affects EIF3H
1 |
EIF3H binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
28514442
EIF3L affects EIF3F
| 1
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3J affects EIF3H
1 |
EIF3J binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3I affects pic
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3H-Flag affects EIF3H
| 1
EIF3H binds EIF3H-Flag. 1 / 1
| 1
isi
"To confirm the interaction between EIF3H and Snail, we then performed a co-IP assay with co-expressed EIF3H-Flag and Snail in HEK293T cells."
32867821
EIF3H affects zinc(2+)
| 1
EIF3H activates zinc(2+). 1 / 1
| 1
reach
"The above result suggests that the complexation of EIF3H with EIF3F further supports the binding of the zinc ion to the same site (XREF_FIG)."
32269044
EIF3H affects xenograft tumor growth
| 1
EIF3H activates xenograft tumor growth. 1 / 1
| 1
eidos
"I EIF3H knockdown suppressed xenograft tumor growth in vivo in mice ."
32867821
EIF3H affects turnover YAP
| 1
EIF3H inhibits turnover YAP. 1 / 1
| 1
eidos
"We further observed that , while depletion of EIF3H results in accelerated turnover rate for YAP ( Fig. 4D & E and Fig. S5H-I ) , elevation of EIF3H led to protection of YAP from beta-TRCP / SCF-mediated YAP degradation ( Fig. 4F and Fig. S5J-K ) and extended the YAP half-life ( Fig. 4G-H ) ."
32269044
EIF3H affects translation auxin response ARFs basic zipper transcription
| 1
EIF3H activates translation auxin response ARFs basic zipper transcription. 1 / 1
| 1
eidos
"This activates eIF3h , which increases ribosomal loading of uORF-containing mRNAs , thus promoting , among others , translation of auxin response factors ( ARFs ) and basic zipper transcription factors ( bZIPs ) ( Kim et al ., 2004 ; Schepetilnikov et al ., 2013 ) ."
33778006
EIF3H affects start
| 1
Mutated EIF3H activates start. 1 / 1
| 1
reach
"One might hypothesize that the rpl24b or eif3h mutations cause a relaxation of start codon recognition specifically for reinitiating ribosomes."
20799971
EIF3H affects stabilization YAP
| 1
EIF3H inhibits stabilization YAP. 1 / 1
| 1
eidos
"Collectively , the results from various lines strongly suggest that the stabilization of YAP due to deregulated EIF3H is a crucial causal factor in promoting tumor invasion and distant metastasis ( Fig. 7P ) ."
32269044
EIF3H affects rs16888589 risk region
| 1
EIF3H binds rs16888589 risk region. 1 / 1
| 1
reach
"Thus, the rs16888589 risk region physically interacts with EIF3H."
20862326
EIF3H affects ribosomal loading uORF-containing mRNAs
| 1
EIF3H activates ribosomal loading uORF-containing mRNAs. 1 / 1
| 1
eidos
"This activates eIF3h , which increases ribosomal loading of uORF-containing mRNAs , thus promoting , among others , translation of auxin response factors ( ARFs ) and basic zipper transcription factors ( bZIPs ) ( Kim et al ., 2004 ; Schepetilnikov et al ., 2013 ) ."
33778006
EIF3H affects removal poly-ubiquitin chain
| 1
EIF3H activates removal poly-ubiquitin chain. 1 / 1
| 1
eidos
"Under oncogenic circumstances , EIF3H directly interacts with YAP and catalyzes the removal of poly-ubiquitin chain on YAP , resulting in YAP stabilization and its transactivation ( 4 ) ."
32269044
EIF3H affects protein
| 1
EIF3H increases the amount of protein. 1 / 1
| 1
reach
"EIF3H knockdown leads to decrease of YAP protein expression and increases ubiquitination, especially the K48-linkage specific polyubiquitination (XREF_FIG and XREF_SUPPLEMENTARY)."
32269044
EIF3H affects process
| 1
EIF3H activates process. 1 / 1
| 1
eidos
"Therefore , EIF3H could promote Snail-mediated EMT process in ESCC ."
32867821
EIF3H affects poly-ubiquitin ubiquitinated Snail
| 1
EIF3H inhibits poly-ubiquitin ubiquitinated Snail. 1 / 1
| 1
eidos
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay ."
32867821
EIF3H affects pic
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3H affects pancreatic cancer cells
| 1
EIF3H activates pancreatic cancer cells. 1 / 1
| 1
eidos
"Furthermore , the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity , promoting apoptosis , arresting cell cycle in G2 and suppressing cell migration ."
35809300
EIF3H affects mTORC1
| 1
EIF3H bound to MTOR inhibits mTORC1. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H affects mTORC1 signaling cascade
| 1
EIF3H inhibits mTORC1 signaling cascade. 1 / 1
| 1
eidos
"Although the role of Eif3h in ASD is not clearly understood , a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin ( mTOR ) and collybistin ( a neuron-specific Rho-GEF ) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD92 ."
33441873
EIF3H affects lung metastasis
| 1
EIF3H activates lung metastasis. 1 / 1
| 1
eidos
"E EIF3H knockdown suppressed lung metastasis in vivo in mice ."
32867821
EIF3H affects lung metastasis nodules
| 1
EIF3H activates lung metastasis nodules. 1 / 1
| 1
eidos
"In the spontaneous lung metastasis model , we observed that loss of EIF3H significantly decreased lung metastasis nodules ."
32269044
EIF3H affects induction
| 1
EIF3H inhibits induction. 1 / 1
| 1
sparser
"Furthermore, overexpressed eIF3h inhibits Myc-dependent induction of apoptosis of primary prostate cells."
18544531
reach
"The striking formation of an enlarged meristematic dome (XREF_FIG) or of a pinformed stem in the eif3h mutant XREF_BIBR suggests that Arabidopsis eIF3h supports stem cell homeostasis, organ initiation, and morphogenesis."
24736281
EIF3H affects hnRNP
| 1
EIF3H binds hnRNP. 1 / 1
| 1
sparser
"The analysis of the eCLIP (cross-linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project () using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
EIF3H activates embryo development. 1 / 1
| 1
reach
"Underexpression of eIF3h causes defects in zebrafish embryo development, suggesting that eIF3h could be directly involved in translation initiation of specific transcripts during embryogenesis."
27210288
EIF3H affects eL24
| 1
EIF3H binds eL24. 1 / 1
| 1
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
EIF3H affects eIF3kl dimer
| 1
EIF3H binds eIF3kl dimer. 1 / 1
| 1
reach
"Affinity purification of N-terminally tagged eIF3k in the absence of eIF3h (strain DeltaeIF3hk, + N-k) yielded an eIF3kl dimer (XREF_FIG) indicating that eIF3k and l are either pre-assembled as a dimer and interact with eIF3 already containing the h subunit or alternatively the eIF3kl dimer binds to eIF3h and assembles with eIF3 as a trimer."
24250809
EIF3H affects development pancreatic cancer
| 1
EIF3H activates development pancreatic cancer. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro ."
35809300
EIF3H affects decrease YAP protein
| 1
EIF3H inhibits decrease YAP protein. 1 / 1
| 1
eidos
"EIF3H knockdown leads to decrease of YAP protein expression and increases ubiquitination , especially the K48-linkage specific polyubiquitination ( Fig. 4I and Fig. S6A ) ."
32269044
EIF3H affects colony
| 1
EIF3H activates colony. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibited cell proliferation and colony formation ."
32867821
EIF3H affects cell mobility
| 1
EIF3H activates cell mobility. 1 / 1
| 1
eidos
"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."
32867821
EIF3H affects aggressiveness squamous cell carcinoma
| 1
EIF3H activates aggressiveness squamous cell carcinoma. 1 / 1
| 1
eidos
"EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability Background Overexpression of eukaryotic translation initiation factor 3H ( EIF3H ) predicts cancer progression and poor prognosis , but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous cell carcinoma ( ESCC ) ."
32867821
EIF3H affects accumulation vimentin
| 1
EIF3H inhibits accumulation vimentin. 1 / 1
| 1
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
EIF3H affects YTHDF2
1 |
YTHDF2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
EIF3H affects YAP ENO2 CTGF
| 1
EIF3H activates YAP ENO2 CTGF. 1 / 1
| 1
eidos
"We first established EIF3H knockdown cells and then added back the wildtype and mutant EIF3H ( EIF3HDDQ / AAA and EIF3HYW / AA ) and found that knockdown EIF3H could decrease YAP , ENO2 and CTGF expression , add back wildtype EIF3H could recover all these proteins expression in MDA-MB-231 and MDA-MB-468 cells ( Fig. 6A ) ."
32269044
EIF3H affects XPO1
1 |
XPO1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26673895
EIF3H affects WUS
| 1
EIF3H activates WUS. 1 / 1
| 1
sparser
"Together, these results are consistent with the notion that translational defects in the eif3h mutant cause activation of WUS , which in turn contributes to the meristem expansion observed in the eif3h mutant."
24736281
EIF3H affects WDR48
1 |
WDR48 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects Ubiquitination
| 1
eidos
"EIF3H knockdown leads to decrease of YAP protein expression and increases ubiquitination , especially the K48-linkage specific polyubiquitination ( Fig. 4I and Fig. S6A ) ."
32269044
EIF3H affects UTP23
| 1
UTP23 binds EIF3H. 1 / 1
| 1
sparser
"Top SNPs for the hyperthymic temperament were also involved in chromatin interactions in neural progenitor cells with EIF3S3:UTP23 in GSE87112 database (Supplementary Table S xref )."
34075027
EIF3H affects USP3
1 |
USP3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects UNK
1 |
UNK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25737280
EIF3H affects UBC
1 |
UBC binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16196087
EIF3H affects Trp119
| 1
EIF3H binds Trp119. 1 / 1
| 1
isi
"Trp119 and Tyr 140 on EIF3H directly interacted with the N-terminal region of YAP1, facilitating complex formation of EIF3H and YAP1 for YAP1 deubiquitylation."
32269044
EIF3H affects TOR
| 1
EIF3H activates TOR. 1 / 1
| 1
reach
"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
EIF3H affects TMEM203
1 |
TMEM203 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects TGFB
| 1
EIF3H activates TGFB. 1 / 1
| 1
reach
"Zhu and colleagues identified that the transforming growth factor-beta and mitogen activated protein kinase pathways are potentially targeted by EIF3H using microarray analysis."
29805516
EIF3H affects TARDBP
1 |
TARDBP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20020773
EIF3H affects TADA2A
1 |
TADA2A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20508642
EIF3H affects Stemness Gastric Cancer Stem Cells
| 1
EIF3H inhibits Stemness Gastric Cancer Stem Cells. 1 / 1
| 1
eidos
"Celastrus orbiculatus Extract Reduces Stemness of Gastric Cancer Stem Cells by Targeting PDCD4 and EIF3H ."
34802261
EIF3H affects Snail.EIF3H
| 1
EIF3H binds Snail.EIF3H. 1 / 1
| 1
isi
"These results revealed the interaction between EIF3H and Snail mediated by the S-P rich domain of Snail.EIF3H interacts with Snail.aVector or EIF3H-Flag plasmid was transfected in HEK293T cells for 24 h. After a 4 h treatment of 10 muM MG132, cell lysate was immunoprecipitated with anti-FLAG M2 beads, and the proteins interact with EIF3H were analyzed by mass spectrometry."
32867821
EIF3H affects Snail switch
| 1
EIF3H activates Snail switch. 1 / 1
| 1
eidos
"The results demonstrated that knockdown of EIF3H suppressed the expression of Snail and Snail-mediated EMT switch in vivo ."
32867821
EIF3H affects Snail stability
| 1
EIF3H activates Snail stability. 1 / 1
| 1
eidos
"We further validated whether EIF3H modulates Snail stability through deubiquitination ."
32867821
EIF3H affects SRRM2
1 |
SRRM2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
EIF3H affects SRRM1
1 |
SRRM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
EIF3H affects SPTBN1
1 |
SPTBN1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21866423
EIF3H affects SORBS3
1 |
SORBS3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25416956
EIF3H affects SOD1
1 |
SOD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29128334
EIF3H affects SNP rs16888589
| 1
EIF3H binds SNP rs16888589. 1 / 1
| 1
reach
"Pittman et al showed that SNP rs16888589 at 8q23.3 bind EIF3H promoter and repressed its transcription XREF_BIBR."
22879968
EIF3H affects SMURF1
1 |
SMURF1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23184937
EIF3H affects SFN
1 |
SFN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17361185
EIF3H affects RPS9
1 |
RPS9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
EIF3H affects RPS20
1 |
RPS20 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
22863883
EIF3H affects RP23-244N6.4
1 |
EIF3H binds RP23-244N6.4. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects RP23-151A15.2
1 |
EIF3H binds RP23-151A15.2. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects RP23-12I13.1
1 |
EIF3H binds RP23-12I13.1. 1 / 1
1 |
biogrid
No evidence text available
26549023
EIF3H affects RFP
| 1
EIF3H binds RFP. 1 / 1
| 1
sparser
"The data showed that the signal of GFP-tagged OsMTA2 (OsMTA2-GFP) was diffusely distributed in both nucleus and cytoplasm ( xref A) and indeed largely overlapped with eIF3h-RFP signal ( xref A)."
34070794
EIF3H affects Q77M19
1 |
EIF3H binds Q77M19. 1 / 1
1 |
virhostnet
No evidence text available
21911578
EIF3H affects PSMD12
1 |
EIF3H binds PSMD12. 1 / 1
1 |
biogrid
No evidence text available
28514442
EIF3H affects PSEN1
| 1
EIF3H binds PSEN1. 1 / 1
| 1
sparser
"In comparison with the rat V-ATPase structure ( xref ), our human V-ATPase structure contains the essential subunit H, which interacts extensively with PS-1 and a-NTD ( xref and xref – xref )."
33065002
EIF3H affects PRRT2
| 1
EIF3H inhibits PRRT2. 1 / 1
| 1
reach
"Thus, we come to the conclusion that EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells at the same time by stabilizing the CCND1 protein structure."
36350008
EIF3H affects PPFIA1
| 1
EIF3H binds PPFIA1. 1 / 1
| 1
sparser
"Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPase) machinery, a multisubunit protein complex in the phagosome membrane that drives luminal acidification."
22087003
EIF3H affects PAXIP1
1 |
EIF3H binds PAXIP1. 1 / 1
1 |
biogrid
No evidence text available
22990118
EIF3H affects PAN2
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3H affects NUP214
| 1
EIF3H binds NUP214. 1 / 1
| 1
reach
"Rabies virus (RV) matrix protein can interact with eIF3h to inhibit the expression of cellular genes."
29173589
EIF3H affects NUMA1
1 |
EIF3H binds NUMA1. 1 / 1
1 |
biogrid
No evidence text available
26344197
EIF3H affects NTS
| 1
EIF3H binds NTS. 1 / 1
| 1
sparser
"Especially the interaction between V 1 and a NT peptides is interesting as these interactions suggest that binding of cytoplasmic V 1 to V o in the vacuole may be initiated by binding of subunit H to a NT as illustrated in xref ."
23071676
EIF3H affects NTRK1
1 |
EIF3H binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
EIF3H affects NP_789740
1 |
EIF3H binds NP_789740. 1 / 1
1 |
virhostnet
No evidence text available
22190034
EIF3H affects NP_705926
1 |
EIF3H binds NP_705926. 1 / 1
1 |
virhostnet
No evidence text available
22190034
EIF3H affects NPM1
1 |
EIF3H binds NPM1. 1 / 1
1 |
biogrid
No evidence text available
23402259
EIF3H affects NP
1 |
EIF3H binds NP. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3H affects NOX1
| 1
EIF3H binds NOX1. 1 / 1
| 1
sparser
"The heme moiety of the sGC in its reduced iron (Fe 2+ ) state is bound to the β subunit H-NOX domain through the axial ligand histidine 105 (His 105), building a penta-coordinate hystidyl–heme complex."
32046325
EIF3H affects NCK2
1 |
EIF3H binds NCK2. 1 / 1
1 |
biogrid
No evidence text available
25416956
EIF3H affects NAP1L1
1 |
EIF3H binds NAP1L1. 1 / 1
1 |
biogrid
No evidence text available
26344197
EIF3H affects NA
1 |
EIF3H binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3H affects Melanoma
| 1
EIF3H activates Melanoma. 1 / 1
| 1
eidos
"EIF3H Knockdown Inhibits Malignant Melanoma through Regulating Cell Proliferation , Apoptosis and Cell Cycle ."
33508274
EIF3H affects MYOM2
| 1
EIF3H binds MYOM2. 1 / 1
| 1
reach
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [115,116]."
32455727
EIF3H affects MTREX
1 |
MTREX binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
EIF3H affects MTOR, and collybistin
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
EIF3H affects MGMT
1 |
EIF3H binds MGMT. 1 / 1
1 |
biogrid
No evidence text available
16226712
EIF3H affects LIMA1
1 |
LIMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects KYSE150
| 1
EIF3H increases the amount of KYSE150. 1 / 1
| 1
isi
"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro (Fig.2e and f), whereas depletion of EIF3H significantly reduced cell proliferation (Fig.2g and h)."
32867821
EIF3H affects IGSF8
1 |
IGSF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3H affects ICAM1
1 |
EIF3H binds ICAM1. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3H affects HSP90AB1
1 |
EIF3H binds HSP90AB1. 1 / 1
1 |
biogrid
No evidence text available
16263121
EIF3H affects HSP90AA1
1 |
EIF3H binds HSP90AA1. 1 / 1
1 |
biogrid
No evidence text available
16263121
EIF3H affects HNRNPA2B1
| 1
reach
"The analysis of the eCLIP (cross linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project (https://www.encodeproject.org) using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
EIF3H affects HNRNPA1
1 |
EIF3H binds HNRNPA1. 1 / 1
1 |
biogrid
No evidence text available
25324306
EIF3H affects HNRNP
| 1
EIF3H binds HNRNP and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
EIF3H affects HECW2
1 |
HECW2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24163370
EIF3H affects GPHN, and collybistin
| 1
GPHN binds EIF3H and collybistin. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects GPBP1L1
1 |
GPBP1L1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28514442
EIF3H affects GNPTAB
| 1
GNPTAB binds EIF3H and EIF3F. 1 / 1
| 1
sparser
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
EIF3H affects G3BP1
1 |
G3BP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26777405
EIF3H affects Eif3a
| 1
EIF3H activates Eif3a. 1 / 1
| 1
reach
"Overexpression of EIF3H does not lead to elevated EIF3, but protein synthesis is enhanced, as is translation of oncogenic mRNAs."
27340783
EIF3H affects ESCC
| 1
EIF3H activates ESCC. 1 / 1
| 1
reach
"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
32867821
EIF3H affects ENO2
| 1
Modified EIF3H decreases the amount of ENO2. 1 / 1
| 1
reach
"We observed that loss of EIF3H in 4T1 cells led to decreased YAP and ENO2 expression."
32269044
EIF3H affects EMT process cell mobility induced
| 1
EIF3H activates EMT process cell mobility induced. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibits the EMT process and cell mobility induced by Snail ."
32867821
EIF3H affects EMT phenotypes
| 1
EIF3H activates EMT phenotypes. 1 / 1
| 1
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
EIF3H affects EIF4G3
1 |
EIF3H binds EIF4G3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects EIF4G
| 1
EIF4G binds EIF3H. 1 / 1
| 1
reach
"One possibility to explain the interaction of eIF4G and eIF3h with the SUMO protease Ulp2 is that they are themselves modified by SUMO."
24818994
EIF3H affects EIF4A2
1 |
EIF3H binds EIF4A2. 1 / 1
1 |
biogrid
No evidence text available
17353931
EIF3H affects EIF4A1
1 |
EIF3H binds EIF4A1. 1 / 1
1 |
biogrid
No evidence text available
28514442
EIF3H affects EIF3J
1 |
EIF3J binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects EIF3I, SXL, and pic
| 1
EIF3I binds EIF3H, SXL, and pic. 1 / 1
| 1
sparser
"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."
21787382
EIF3H affects EIF3H-Flag
| 1
EIF3H binds EIF3H-Flag. 1 / 1
| 1
isi
"To confirm the interaction between EIF3H and Snail, we then performed a co-IP assay with co-expressed EIF3H-Flag and Snail in HEK293T cells."
32867821
EIF3H affects EIF3FP3
1 |
EIF3H binds EIF3FP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects EIF1B
1 |
EIF1B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17353931
EIF3H affects E6
1 |
EIF3H binds E6. 1 / 1
1 |
virhostnet
No evidence text available
22898364
EIF3H affects DFO-
| 1
EIF3H activates DFO-. 1 / 1
| 1
reach
"We noted that the silencing of eIF3H alone was able to reverse the DFO- and MG132 mediated HIF-1alpha up-regulation (XREF_FIG), resulting in a ~ 2-fold decrease in cellular HIF-1alpha protein levels relative to control (siScramble (siScr) + MG132 or DFO)."
25166596
EIF3H affects DDX3X
1 |
DDX3X binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
18628297
EIF3H affects Cell Survival
| 1
reach
"Knockdown of EIF3H could decrease cell viability through both cell cycle arrest and apoptosis induction and inhibited the formation of colonies in anchorage independent conditions in breast cancer cells."
29805516
EIF3H affects CYLD
1 |
CYLD binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
27591049
EIF3H affects CSNK2B
1 |
CSNK2B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects CSNK2A2
1 |
CSNK2A2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects CSN7
| 1
EIF3H binds CSN7. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H affects CPNE2
1 |
CPNE2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28514442
EIF3H affects CPEB2B
| 1
EIF3H activates CPEB2B. 1 / 1
| 1
reach
"Furthermore, we provide data indicating that the EIF3H subunit of the pre and initiation complex may aid CPEB2B in initiating HIF1alpha translation via preferential association with this protein.Therefore, the alternative splicing of CPEB2 is a novel regulator of HIF1alpha during hypoxia and targeting the expression of CPEB2B could in turn be used to regulate HIF1 in patients suffering from chronic hypoxic disorders.Seminal studies in the field have demonstrated that CPEB2 localizes via a low complexity sequence to stress granules which also contain mRNA transcripts (22)."
| DOI
EIF3H affects COPS8
| 1
COPS8 binds EIF3H. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H affects COPS5
1 |
COPS5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
EIF3H affects CDK2
1 |
CDK2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21319273
EIF3H affects CD81
1 |
CD81 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3H affects CCT_complex
| 1
CCT_complex binds EIF3H. 1 / 1
| 1
sparser
"We also identified eIF3h as a regulator of dendrite development ( xref ), although how CCT interacts with eIF3h in dendrites awaits further study."
33100975
EIF3H affects CCND1
| 1
EIF3H inhibits CCND1. 1 / 1
| 1
reach
"Mechanistically, we found that EIF3H knockdown can promote the degradation of CCND1 and the proteolysis of CCND1 is mediated by ubiquitin-proteasome system (UPS)."
36350008
EIF3H affects BRCA1
1 |
BRCA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26831064
EIF3H affects BAG6
1 |
BAG6 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects AteIF3f protein
| 1
EIF3H binds AteIF3f protein. 1 / 1
| 1
reach
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
EIF3H affects ARPC5
1 |
EIF3H binds ARPC5. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects ARHGEF9
| 1
ARHGEF9 binds EIF3H. 1 / 1
| 1
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects ADGRB1
1 |
EIF3H binds ADGRB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects ABI2
1 |
ABI2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25416956
EIF3H affects ABCE1
1 |
EIF3H binds ABCE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects A18
| 1
EIF3H binds HNRNP and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
EIF3H affects 6 A
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
EIF3H affects 293T
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
EIF3FP3 affects EIF3H
1 |
EIF3H binds EIF3FP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects GNPTAB
| 1
GNPTAB binds EIF3H and EIF3F. 1 / 1
| 1
sparser
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
EIF3F affects EIF4G1
| 1
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
EIF3F affects EIF3L
| 1
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3F affects EIF3H, and GNPTAB
| 1
GNPTAB binds EIF3H and EIF3F. 1 / 1
| 1
sparser
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
EIF3F affects EIF3H, and EIF4G1
| 1
EIF3H binds EIF3F and EIF4G1. 1 / 1
| 1
sparser
"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."
25148142
EIF3F affects EIF3D
| 1
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3E affects EIF3C
| 1
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3D affects EIF3L
| 1
EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3D affects EIF3B
| 1
EIF3H binds EIF3D and EIF3B. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3C affects EIF3E
| 1
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3B affects EIF3D, and EIF3H
| 1
EIF3H binds EIF3D and EIF3B. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3B affects EIF3C
| 1
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3A affects EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
| 1
EIF3K binds EIF3J, EIF3A, EIF3I, EIF3H, EIF3G, EIF3F, and EIF3D. 1 / 1
| 1
sparser
"In , it has also been shown that eIF3a interacts with eIF3d, eIF3f, eIF3g, eIF3h , eIF3i , eIF3j and eIF3k ."
20647036
EIF3A affects EIF3C
| 1
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
1 |
EIF3K binds EIF3J, EIF3A, EIF3I, EIF3H, EIF3G, EIF3F, EIF3E, EIF3D, EIF3C, and EIF3B. 1 / 1
1 |
hprd
No evidence text available
14519125
EIF3A affects EIF3B
| 1
EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF1B affects EIF3H
1 |
EIF1B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17353931
EEF1A1 affects EIF3H, EIF4EBP1, EIF4G3, eIF, and hnRNP
| 1
EEF1A1 binds EIF3H, EIF4EBP1, EIF4G3, eIF, and hnRNP. 1 / 1
| 1
sparser
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3 (Figure xref )."
26824423
E6 affects EIF3H
1 |
EIF3H binds E6. 1 / 1
1 |
virhostnet
No evidence text available
22898364
DDX3X affects EIF3H
1 |
DDX3X binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
18628297
D-glucopyranose affects EIF3H
1 |
D-glucopyranose decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
22634610
CYLD affects EIF3H
1 |
CYLD binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
27591049
CSNK2B affects EIF3H
1 |
CSNK2B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
CSNK2A2 affects EIF3H
1 |
CSNK2A2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
CSN7 affects EIF3H
| 1
EIF3H binds CSN7. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
CPNE2 affects EIF3H
1 |
CPNE2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28514442
COPS8 affects EIF3H
| 1
COPS8 binds EIF3H. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
COP9 signalosome subunits affects EIF3H
| 1
COP9 signalosome subunits inhibits EIF3H. 1 / 1
| 1
reach
"Reducing the copy number of eIF3f or eIF3h reduced the growth inhibitory phenotype of DTrc8 over-expression, much like reduction of the COP9 signalosome subunits, CSN5 and 6."
20068067
COE affects EIF3H
| 1
COE decreases the amount of EIF3H. 1 / 1
| 1
reach
"The results of previous studies indicated that COE may be able to inhibit the stemness of gastric cancer stem cells (GCSCs) by regulating PDCD4 and EIF3H expression."
34802261
CDK2 affects EIF3H
1 |
CDK2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21319273
CD81 affects EIF3H
1 |
CD81 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
CCN2 affects EIF3H
| 1
CCN2 activates EIF3H. 1 / 1
| 1
reach
"As shown in XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, knockdown of either the YAP and CTGF expression abrogated EIF3H driven tumor cell invasion."
32269044
BRCA1 affects EIF3H
1 |
BRCA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26831064
BAG6 affects EIF3H
1 |
BAG6 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
AteIF3f protein affects EIF3H
| 1
EIF3H binds AteIF3f protein. 1 / 1
| 1
reach
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
AtS6K1 affects EIF3H
| 1
AtS6K1 phosphorylates EIF3H. 1 / 1
| 1
reach
"Upon auxin treatment, AtTORC1 associate with the polysome, phosphorylates AtS6K1, which in turns phosphorylates eIF3h."
33778006
Antirheumatic Agents increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
24449571
ATPase activity affects EIF3H
| 1
ATPase activity binds EIF3H. 1 / 1
| 1
sparser
"The structural similarity suggests how subunit H may interact with the ATPase itself or with other proteins."
11416198
AS1 mRNA affects EIF3H
| 1
AS1 mRNA inhibits mutated EIF3H. 1 / 1
| 1
reach
"In addition, the AS1 mRNA has reduced ribosome occupancy in the eif3h mutant (XREF_TABLE)."
24736281
ARPC5 affects EIF3H
1 |
EIF3H binds ARPC5. 1 / 1
1 |
biogrid
No evidence text available
19615732
ARHGEF9 affects EIF3H
| 1
ARHGEF9 binds EIF3H. 1 / 1
| 1
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
ADGRB1 affects EIF3H
1 |
EIF3H binds ADGRB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ABI2 affects EIF3H
1 |
ABI2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25416956
ABCE1 affects EIF3H
1 |
EIF3H binds ABCE1. 1 / 1
1 |
biogrid
No evidence text available
19615732
A18 affects HNRNP
| 1
EIF3H binds HNRNP and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
6 A affects METTL3
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
3-methylcholanthrene increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18804290
293T affects GPHN
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
4,4'-diaminodiphenylmethane increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18648102