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IndraLab

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CDKN2A is modified
| 4672 1
CDKN2A is methylated. 10 / 4672
| 4671 1
sparser
"Several reports have claimed predictive value ofp16 INK4a methylation ( xref , xref – xref , xref , xref , xref ) which we could not replicate in our cohort."
sparser
"However, there was no difference in promoter methylation in the ERalpha, ERbeta and p16 genes."
sparser
"p16 methylation was relatively common in PCM, but did not influence the survival outcome."
sparser
"CDKN2A has been proved to bear a striking resemblance to classic TSGs such as p53 , and to be an important negative regulator of cell growth and proliferation. xref It is largely reported that a critical mechanism for silencing CDKN2A is hypermethylation of its regulatory region. xref Abnormal methylation of the CDKN2A gene is a common event in many types of human cancer, as well as in cervical cancer. xref , xref – xref However, conclusions regarding the role of methylated CDKN2A during the carcinogenesis of cervical cancer are inconsistent."
sparser
"All cases with p16 methylation had experienced more than 15 years of chromate exposure."
sparser
"PCR revealed p16 methylation and no alteration in p53."
sparser
"The results demonstrated that the P16 , RASSF1A and APC methylation with low sensitivity (< 0.5) and AUC (< 0.8) could not distinguish lung cancer and non-tumor samples well."
sparser
"Of the nine genes which we studied, only methylation of CDKN2A and RUNX3 appeared to increase in frequency in the progression from BE to cancer, and only six of the nine genes increased in the extent of methylation."
sparser
"After 10 days of treatment, we isolated the DNA from the cells for measurement p16 promoter methylation."
sparser
"As shown in the Figure xref , Fagan plot analysis demonstrated that the probabilities of a patient being diagnosed with EC were 82%, 93%, and 98% following a positive result for methylation of CDKN2A , where the pretest probabilities of being diagnosed with EC were set to 25%, 50%, and 75%, respectively; when the test was negative, the probabilities of diagnosis with EC reduced to 14%, 33%, and 60%, respectively."
CDKN2A is methylated on arginine. 1 / 1
| 1
sparser
"Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues."
CXXC1 affects CDKN2A
| 63
CXXC1 methylates CDKN2A. 10 / 63
| 63
sparser
"The above authors also analyzed six PCNSL for p16 INK4A CpG island methylation and detected aberrant patterns in three, in which p16 INK4A mRNA or pro[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"Expression of p16, CDKN2A HD and 5' CDKN2A CpG island methylation was studied in 25 oligodendrogliomas by immunohistochemistry and PCR amplification."
sparser
"Results were supported by modulation of global DNA methylation and the modulation of promoter CpG methylation of p16, MLH1, and COX-2 genes."
sparser
"Similarly, the mean age of 4 patients who had PanINs showing p16 CpG island methylation was also older (70.8 years) than that of the other 25 patients (62.0 years)."
sparser
"Southern blots showed methylation of p15 at one CpG site in an Eag I site, and no methylation of p16 at one CpG site in a Sac II site."
sparser
"11 All four of the invasive carcinomas showing p16 CpG island methylation also showed ppENK gene methylation."
sparser
"We used two different technical approaches to detect changes in CpG methylation in the promoter region of the CDKN2A gene; methylation-specific PCR (MSP) analysis of bisulfite-converted DNA and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)."
sparser
"Results from the GMDR model showed that interaction existed among the high exposure of 1-hydroxy pyrene and the CpG island methylation of p16, FHIT in CINⅠ and CINⅡ/Ⅲ group."
sparser
"CpG methylation of the p16INK4a, RASSF1A, E cadherin, and GSTP1 genes was correlated to the reduction of mRNA levels in the cell lines, and mRNA expression of these 4 genes were indeed restored by low concentrations (2-6 micromol/L) of As2O3 through demethylation, as well as 1 micromol/L of 5-aza-2'-deoxycytidine."
sparser
"There was no significant correlation between P16 CpG methylation and HPV16 infection in Uyghur patients with CSCC."
CDKN2A affects CDKN2A
| 29 14
CDKN2A methylates CDKN2A. 10 / 43
| 29 14
sparser
"Then, future studies are needed to evaluate the interaction of HPV16 infection and p16INK4a promoter methylation on expression p16 in HNSCC."
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"Nonetheless, it is unlikely that chemotherapy use substantially differed according to CDKN2A methylation or loss of CDKN2A (p16) in tumor, since such data were not available for treatment decision making."
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"CDKN2A methylation and loss of CDKN2A (p16) in colorectal cancer."
sparser
"Prognostic significance of CDKN2A promoter methylation or loss of CDKN2A (p16) in colorectal cancer xref - xref or normal-appearing mucosa adjacent to colorectal cancer xref has been studied ( xref )."
sparser
"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
sparser
"Every 1 μg/m 3 increase of PM 10 resulted in 0.01% and 0.02% decrease of LINE - 1 and iNOS methylation, and 0.029% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% decrease of iNOS promoter methylation in lung tissue DNA, and 0.18 and 0.19 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
sparser
"In consistent with this hypothesis, we found that P16 methylation by P16-Dnmt directly increased the paclitaxel IC50 value of BGC823 cells, whereas reactivation of P16 demethylation by P16-TET directly decreased the IC50 in H1299 cells."
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"However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p16) expression independent of CIMP status remains uncertain."
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"In our current study, we have found that CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis of colorectal cancer patients."
sparser
"We therefore evaluated the prognostic role of CDKN2A promoter methylation and loss of CDKN2A (p16) independent of CIMP status, utilizing the database of a large number (N=902) of clinically and molecularly-annotated colorectal cancers."
ARF affects CDKN2A
| 28
ARF methylates CDKN2A. 10 / 28
| 28
sparser
"Association ofp16 INK4A andp14 ARF methylation and tumor histology in cancer."
sparser
"Further large-scale studies with well-designed research are necessary to validate the role ofp16 INK4A andp14 ARF promoter methylation in the prognosis and clinical effects of RCC patients in the future."
sparser
"Association ofp16 INK4A andp14 ARF methylation and tumor grade in cancer."
sparser
"However, the clinical effects ofp16 INK4A andp14 ARF promoter methylation on renal cell carcinoma (RCC) remain to be clarified."
sparser
"Of these studies, which involvedp16 INK4A andp14 ARF gene promoter methylation, nine studies evaluated the association betweenp16 INK4A promoter methylation and RCC risk, five studies assessed the correlation betweenp14 ARF promoter methylation and RCC risk, ten studies evaluated the relation betweenp16 INK4A promoter methylation and clinicopathological features, and four studies evaluated the relation betweenp14 ARF promoter methylation and clinicopathological features."
sparser
"Although numerous studies have been conducted to evaluate the role ofp16 INK4A andp14 ARF promoter methylation in RCC, the results are still inconsistent and controversial."
sparser
"Therefore, we conducted this study of all available articles to further evaluate the effects ofp16 INK4A andp14 ARF promoter methylation in RCC."
sparser
"In conclusion, our study showed that RCC had a higherp16 INK4A andp14 ARF gene promoter methylation than did nonmalignant control patients."
sparser
"Although some studies involvingp16 INK4A andp14 ARF promoter methylation included patients with RCC, the studies published in this field have had small sample sizes."
sparser
"The pooled OR from five studies and two studies showed thatp16 INK4A andp14 ARF promoter methylation was not significantly associated with lymph node status in RCC (OR = 0.69, 95% CI = 0.18-2.69, P = 0.595; OR = 0.35, 95% CI = 0.04-2.83, P = 0.326, respectively) (Table xref )."
MST1 affects CDKN2A
| 7 2
MST1 methylates CDKN2A. 9 / 9
| 7 2
sparser
"Unfortunately, the p16 INK4a transcriptional activation and HR-HPV-E7 oncogene expression were not analyzed in most of the studies demonstrating methylation of p16 INK4a by MSP in some portion of cervical carcinomas [ xref - xref ]."
sparser
"The MAGE -positive group in sputum showed a statistically significant higher MAGE A3 unmethylation and p16 MSP methylation rate than the MAGE negative group."
sparser
"Fig xref shows the results of p16 promoter DNA methylation by MSP."
sparser
"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
sparser
"Because inactivation of the INK4a locus by promoter hypermethylation has been demonstrated in primary tumors from both human and rodents [3,5,25,27] , we examined these murine lung tumors for methy[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"Unfortunately, the p16 INK4a transcriptional activation and HR-HPV-E7 oncogene expression were not analyzed in most of the studies demonstrating methylation of p16 INK4a by MSP in some portion of cervical carcinomas [XREF_BIBR - XREF_BIBR]."
sparser
"Detection of p16 and MGMT promoter methylation by MSP."
sparser
"In the present study, we have, however, found that betaine had no effect on methylation of p16 or c-myc by MSP and there were no differences in c-myc methylation among the five groups of rats."
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"We detected methylation of p16 (INK4A) (17/43), p14 (ARF) (11/42) and TIMP3 (9/44) in MB and others by MSP."
DNMT1 affects CDKN2A
| 2 6
DNMT1 methylates CDKN2A. 7 / 7
| 2 5
sparser
"In consistent with this hypothesis, we found that P16 methylation by P16-Dnmt directly increased the paclitaxel IC50 value of BGC823 cells, whereas reactivation of P16 demethylation by P16-TET directly decreased the IC50 in H1299 cells."
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"Regulation of DNMT1 and DNMT3A by HBx promoted hypermethylation of p16 (INK4A) promoter region."
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"DNMT1 has been shown to be specifically over-expressed in NSCLC lung tumours compared to normal cells where DNMT1 over-expression resulted in increased methylation of the TSGs, FHIT, p16 INK4a and RARbeta 21."
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"DNMT1 siRNA induces demethylation of the tumor suppressor genes SOCS1 and p16."
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"In a multivariate analysis, CIMP and MLH1 and CIMP and p16 INK4a methylation statuses were predictive of prognosis, and the OS was longer for patients with tumors CIMP- and MLH1-M, as well as CIMP- and p16 INK4a -M. Furthermore, DNMT1 is significantly overexpressed in tumors than in normal tissues as well as in CIMP+ than CIMP- tumors."
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"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
sparser
"In contrast, P16 -specific methylation by P16-Dnmt significantly increased paclitaxel resistance of lung cancer HCC827 cells and gastric cancer BGC823 cells (IC50 values increased from 18.2 to 24.0 ng/ml and 0.18 to 0.81 µg/ml, respectively; P =0.049 and <0.001, respectively)."
Modified DNMT1 leads to the methylation of CDKN2A. 1 / 1
| 1
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"Besides the role played by the DNMT family in DNA hypermethylation and tumorigenesis, supression of DNMT1 expression in bladder cancer cells was shown to induce demethylation and reactivation of the silenced tumor suppressor gene CDKN2A."
GNAS affects CDKN2A
| 6
GNAS methylates CDKN2A. 6 / 6
| 6
sparser
"Because the INK4 gene is frequently inactivated by de novo methylation, we investigated the frequency of INK4a exon 1alpha methylation in a subset of 120 primary breast cancers using methylation-specific PCR; 24 of these were methylated."
sparser
"Out of 50 lung cancer tissues, 16 were positive for the p16 gene exon 1 methylation (32.0%), and 14 for the p16 gene exon 2 deletion (28.0%)."
sparser
"The functional consequences of CDKN2A exon 2 DNA methylation in tumor samples merits further investigation."
sparser
"Nguyen and colleagues 31 reported a high frequency of p16 INK4a exon 2 methy[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"However, in 54 cases of normal lung tissues, only 2 showed the p16 gene exon 1 methylation(3.7%), and none showed the p16 gene exon 2 deletion."
sparser
"Since Herman et al xref first reported inactivation of CDKN2A by DNA methylation in prostate cancer, other researchers have investigated the role of hypermethylated CDKN2A in the carcinogenesis and progression of prostate cancer. xref , xref – xref , xref – xref Although there was no significant association between CDKN2A low expression and increased CDKN2A exon 2 methylation, the exon 2 methylation may be a potential biomarker for prostate tumor. xref These results were confirmed by other investigators."
CDKN2B affects CDKN2A
| 2 3
CDKN2B methylates CDKN2A. 5 / 5
| 2 3
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"In RRP Case 5, aberrant methylation of BRAC2, APC and CDKN2A in the reference papilloma biopsy and CDKN2B in biopsy 2 were also identified in the subsequent progression lesions (XREF_TABLE, XREF_FIG)."
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"Accumulating evidence suggests an almost universal inactivation of the RB pathway in HCC, including by promoter hypermethylation of the p16 INK4a (~ 50% of cases) or p15 INK4b (~ 15% of cases) genes, and amplification of the gene coding for Cyclin D1 (~ 30% of cases)."
sparser
"Their results indicated that the rates ofp15 INK4B andp16 INK4A promoter methylation in MM samples were significantly higher compared with normal controls."
sparser
"Another intriguing observation in our study was the positive significant correlation between ANRIL exon 1–5 expression andp15 INK4b andp16 INK4a methylation (r = 0.23, p = 0.001 and r = 0.24, p = 0.001, respectively)."
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"In RRP Case 5, aberrant methylation of BRAC2, APC and CDKN2A in the reference papilloma biopsy and CDKN2B in biopsy 2 were also identified in the subsequent progression lesions (XREF_TABLE)."
TP53 affects CDKN2A
| 4
TP53 methylates CDKN2A. 2 / 2
| 2
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"Beyond global methylation alterations, several recent epidemiologic studies have reported positive gene specific associations between in utero exposure to arsenic and promoter methylation of CDKN2A (encoding p16INK4A) and TP53 measured in human umbilical cord peripheral blood lymphocytes (PBLs)."
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"There were no statistically significant differences in age or gender in the methylation of p14 ARF, DAPK, and TMS1 and ASC or p53 gene mutation on p53-Bax mitochondrial apoptosis pathway."
Modified TP53 leads to the methylation of CDKN2A. 1 / 1
| 1
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"6 Reported molecular and genetic alterations in MCN of the pancreas include mutations in KRAS (V-Ki-ras2, Kirsten rat sarcoma viral oncogene homolog) oncogene 7 and DPC4 and SMAD4 (deleted in pancreatic cancer locus 4 protein) gene, XREF_BIBR, XREF_BIBR promoter hypermethylation of p16 ink4a / CDKN2A (inhibitor of cyclin dependent kinase 4/cyclin dependent kinase inhibitor 2A), and aberrant p53 protein expression."
Mutated TP53 leads to the methylation of CDKN2A. 1 / 1
| 1
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"Correlation between promoter methylation of p14 ARF, TMS1 and ASC, and DAPK, and p53 mutation with prognosis in cholangiocarcinoma."
PRMT6 affects CDKN2A
| 1 3
PRMT6 methylates CDKN2A on R138. 1 / 1
| 1
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
PRMT6 methylates CDKN2A on R131. 1 / 1
| 1
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
PRMT6 methylates CDKN2A on arginine. 1 / 1
| 1
sparser
"Together, data presented in this report establish that methylation at specific arginine residues of p16 protein by PRMT6 may be critical for the activity of p16."
PRMT6 methylates CDKN2A on R22. 1 / 1
| 1
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
MS-MLPA affects CDKN2A
| 4
MS-MLPA methylates CDKN2A. 4 / 4
| 4
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"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
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"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
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"MSP confirmed MS-MLPA methylation of BRCA2 (biopsy 1), APC (biopsy 4), GSTP1 (biopsy 6), and CDKN2A (biopsies 5 and 6)."
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"MSP confirmed MS-MLPA methylation of BRCA2 (biopsy 1), APC (biopsy 4), GSTP1 (biopsy 6), and CDKN2A (biopsies 5 and 6)."
LGI1 affects CDKN2A
| 4
LGI1 methylates CDKN2A. 4 / 4
| 4
sparser
"Initial experiments investigating gene-specific methylation using methylation-specific PCR and bisulfite sequencing, revealed partial methylation of p16 in the liver of rats treated with HCB and TCDD."
sparser
"Moreover, partial methylation of p14ARF was the most common pattern observed in primary colorectal cancers."
sparser
"Partial methylation of the p16 gene was also demonstrated in three of eight primary leukemia samples with this translocation, suggesting that the p16 gene inactivation by hypermethylation might play a role in the leukemogenesis and disease progression of ALL with 11q23 translocation."
sparser
"Moreover, partial methylation of p14ARF was the most common pattern observed in primary colorectal cancers."
dioxygen affects CDKN2A
| 3
Dioxygen leads to the methylation of CDKN2A. 3 / 3
| 3
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"Reactive oxygen induced carcinogenesis causes hypermethylation of p16 (Ink4a) and activation of MAP kinase."
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"Of interest, high PlGF expressing tumors such as choriocarcinoma also have hypermethylation of p16ink4a, which may be mediated by the reactive oxygen species mediated pathway for regulation of PlGF expression."
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"Our conclusions from this is that reactive oxygen induced carcinogens cause hypermethylation of p16ink4a and MAP kinase activation."
X affects CDKN2A
| 3
X leads to the methylation of CDKN2A. 3 / 3
| 3
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"HBx induced DNA hypermethylation of p16 (INK4a) promoter to repress its expression, which subsequently led to activation of G1-CDKs, phosphorylation of pRb, activation of E2F1, and finally transcriptional activation of DNMT1."
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"DNMT1 and DNMT3A may play important roles in the process of HBx inducing hypermethylation of the p16 (INK4A) promoter in the early stages of HBV associated HCC."
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"Moreover, HBx induces hypermethylation of p16 (INK4A) promoter through DNMT1 and DNMT3A."
TRAP affects CDKN2A
| 3
TRAP leads to the methylation of CDKN2A. 3 / 3
| 3
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"In contrast, prolonged TRAP exposure could effectively induce p16 CDKN2A gene hypermethylation, thus reduce p16 CDKN2A gene expression, affect cell cycle, and finally play an important role in the development of multiple pulmonary diseases."
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"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
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"These findings suggest that rapid TRAP exposure may not be sufficient to increase p16 CDKN2A gene promoter methylation, which could be associated with the powerful clearance ability of the respiratory system."
NSUN2 affects CDKN2A
| 2
NSUN2 methylates CDKN2A. 2 / 3
| 2
sparser
"In vitro methylation assays show that NSun2 methylates the p16 3′UTR at A988."
sparser
"NSun2 methylates the p16 3’UTR at A988."
APC affects CDKN2A
| 2 1
APC methylates CDKN2A. 3 / 3
| 2 1
sparser
"After sex, season, SO 2 level, temperature, and age were adjusted, the results showed that every 1 μg/m 3 increase of PM 2.5 resulted in 0.04% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% and 0.06% decrease of LINE - 1 and iNOS methylation in lung tissue DNA, 0.01% and 0.01% increase of APC and p16 CDKN2A promoter methylation in lung tissue DNA, and 0.64 and 0.66 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
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"Furthermore, since 5mTHF is involved in the supply of methyl groups to the remethylation cycle in which DNA is a terminal acceptor, FA may alter BC risk through altered epigenetic regulation of tumour suppressor genes as BC can involve hypermethylation of P16INK4a, BRCA1, BRCA2, oestrogen receptor (ER)-alpha, retinoic acid receptor-beta2, APC, and RASSF1A promoters leading to lower transcription and to impaired DNA repair."
sparser
"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
AADAC affects CDKN2A
| 3
AADAC leads to the methylation of CDKN2A. 3 / 3
| 3
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"Combination treatment of ATRA and DAC induced DNA hypomethylation as well as gene expression of p16 and RARbeta, which contributed to the growth inhibition, differentiation, apoptosis and cell cycle arrest of U937 cells."
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"In spite of CDKN2A hypomethylation induced by DAC, there was n't any change in the expression level of the gene (XREF_FIG)."
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"To further understand how DAC causes hypomethylation of the p16 INK4A and XAF1 genes we examined the status of DNA methyl transferase (DNMT) isozymes which are known to catalyze DNA methylation."
nickel(2+) affects CDKN2A
| 2
Nickel(2+) leads to the methylation of CDKN2A. 2 / 2
| 2
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"Nickel was found to promote gene specific hypermethylation of the tumor suppressor p16 in several studies."
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"Methylation of RAR-beta2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats."
lpp affects CDKN2A
| 2
Lpp methylates CDKN2A. 2 / 2
| 2
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1–3)."
hMLH1 affects CDKN2A
| 2
HMLH1 leads to the methylation of CDKN2A. 2 / 2
| 2
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"EBV-infection in cardiac and non cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1."
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"EBV-Infection in Cardiac and Non Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1."
all-trans-retinoic acid affects CDKN2A
| 2
All-trans-retinoic acid leads to the methylation of CDKN2A. 2 / 2
| 2
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"Combination treatment of ATRA and DAC induced DNA hypomethylation as well as gene expression of p16 and RARbeta, which contributed to the growth inhibition, differentiation, apoptosis and cell cycle arrest of U937 cells."
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"Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells."
WIZ affects CDKN2A
| 2
WIZ methylates CDKN2A. 2 / 2
| 2
sparser
"Methylation status of INK4a-ARF locus The CpG WIZ p16 Methylation Assay Kit was used (OncorInc, Gaithersburg, MD, USA) [33] according to the manufacturer’s description."
sparser
"The methylation status of the 5′ CpG island in the promoter region of the p16 gene was determined with the CpG Wiz p16 Methylation kit (Oncor, Gaithersburg, MD), based on the method developed by Herma[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
TWSG1 affects CDKN2A
| 2
TWSG1 methylates CDKN2A. 2 / 2
| 2
sparser
"Until now, p16 tumor suppressor gene promoter methylation has been the most studied [ xref ]."
sparser
"Data related to epigenetics of salivary gland tumors including p16 and p14 TSG methylation status are very scarce."
RARB affects CDKN2A
| 1 1
RARB leads to the methylation of CDKN2A. 2 / 2
| 1 1
sparser
"Methylation frequency was significantly higher in NAF than adjacent normal tissue for p16 and marginally higher for RAR-β , suggesting that the assessment of p16 and perhaps RAR-β methylation levels in NAF may provide information on whether a breast contains cancer."
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"In our study, we found no association between one-carbon nutrients intake and likelihood of gene promoter methylation for E- cadherin, p16 or RAR-beta 2 in breast tumors or any indication of more than additive interaction for folate and alcohol for E- cadherin promoter methylation."
PRC2_complex affects CDKN2A
| 2
| 2
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"This cooperation involves recruitment of PRC2, which trimethylates H3K27 at the E-cadherin and CDKN2A gene promoters 67."
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"These observations suggest that, in the absence of JDP2, H3K27 is methylated by PRC2, and the p16 Ink4a / Arf locus is silenced by PRC1, whereas the increased expression of JDP2 helps to release PRC1 and PRC2 from the p16 Ink4a / Arf locus, thereby reducing H3K27 methylation."
N-methyl-N'-nitro-N-nitrosoguanidine affects CDKN2A
| 2
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"N-methyl-N '-nitro-N-nitrosoguanidine, a well-known gastric carcinogen, has been demonstrated to induce CpG island hypermethylation of p16, and this hypermethylation increased with lesion progression along the multistep gastric carcinogenesis in the rat stomach."
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"p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N '-nitro-N-nitrosoguanidine."
MTR affects CDKN2A
| 2
MTR methylates CDKN2A. 2 / 2
| 2
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1–3)."
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
KRAS affects CDKN2A
| 1 1
KRAS leads to the methylation of CDKN2A. 2 / 2
| 1 1
sparser
"Data from KRAS transformation studies suggest that activated KRAS promotes P16 methylation [ xref ]."
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"Previous report also showed that the mutated K-ras induces p16 hypermethylation, resulting in transcriptional silencing of INK4-ARF in human embryonic stem cells XREF_BIBR."
Histone affects CDKN2A
| 1 1
Histone methylates CDKN2A. 2 / 2
| 1 1
sparser
"Histone methylation in APC, INK4a, and MLH has been frequently observed in sporadic colon cancer: APC and INK4a are tumor suppressor genes and MLH controls DNA stability ( xref – xref )."
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"These studies for the first time link Twist-1 to histone methylation of the Ink4A and Arf locus by controlling the expression of histone methyltransferases as well as the expression of other bHLH factors."
GPI affects CDKN2A
| 2
GPI leads to the methylation of CDKN2A. 2 / 2
| 2
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"Moreover, Lu et al. discovered that PHI induced histone H3 hyperacetylation and p16 hypomethylation in a concentration dependent manner in myeloma cell line RPMI8226 [XREF_BIBR]."
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"PHI induces p16 DNA hypomethylation."
EZH2 affects CDKN2A
| 2
EZH2 leads to the methylation of CDKN2A. 2 / 2
| 2
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"The knockdown of EZH2 in cultured CC cells decreased p16 INK4a methylation and decreased binding of EZH2 to the p16 INK4a gene promoter."
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"Ezh2 knockdown with shRNA eliminated H3K27me mediated DNA methylation of the p16 (INK4a) gene in presenescent MSCs, but had no effect on H3K9me enhanced DNA hypermethylation in the cells after senescence escape."
DNMT3A affects CDKN2A
| 2
DNMT3A leads to the methylation of CDKN2A. 1 / 1
| 1
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"Regulation of DNMT1 and DNMT3A by HBx promoted hypermethylation of p16 (INK4A) promoter region."
Modified DNMT3A leads to the methylation of CDKN2A. 1 / 1
| 1
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"Surprisingly, DNMT3a overexpression did not increase promoter methylation or expression of CDKN2a and NES, but greatly affected both promoter methylation and expression of the mammary lineage gene KRT19 (representative patient samples in XREF_FIG F, 3G, and XREF_SUPPLEMENTARY C)."
AHR affects CDKN2A
| 2
AHR leads to the methylation of CDKN2A. 2 / 2
| 2
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"Additionally, in keratinocytes AHR is reported to induce the silencing and hypermethylation of the CDKN2A (p16) tumour suppressor gene and the inhibition of p53 signalling [XREF_BIBR]."
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"In human keratinocytes, AhR was reported to induce silencing and hypermethylation of the CDKN2A (p16) tumor suppressor gene and inhibition of p53 signaling."
tumour suppressor affects CDKN2A
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Tumour suppressor methylates CDKN2A. 1 / 1
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sparser
"It indicates that the contribution of p16 tumour suppressor methylation in DLBCL development might be of high importance."
technetium atom affects CDKN2A
| 1
Technetium atom methylates CDKN2A. 1 / 1
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sparser
"Interestingly, low-dose TCS elevated p16 gene methylation and inhibited p16 expression, which were not observed in high-dose (10μM) group."
spn-A affects CDKN2A
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Spn-A methylates CDKN2A. 1 / 1
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sparser
"In the SWS cohort, lower umbilical cord CDKN2A DMR methylation predicted increased adiposity at ages 1, 4 and 6 years but not at birth, suggesting that CDKN2A methylation may be linked to the gain of fat mass postnatally."
selenium atom affects CDKN2A
| 1
Selenium atom leads to the methylation of CDKN2A. 1 / 1
| 1
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"Furthermore, Se deficiency has been demonstrated to cause global hypomethylation and promoter methylation of the p16 and p53 tumor suppressor genes [XREF_BIBR]."
quercetin affects CDKN2A
| 1
Quercetin leads to the methylation of CDKN2A. 1 / 1
| 1
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"Flavonol quercetin from citrus fruits and buckwheat inhibited the proliferation of colon cancer RKO cells by reversing hypermethylation of the CDKN2A gene promoter DNA [XREF_BIBR, XREF_BIBR]."
paaK affects CDKN2A
| 1
PaaK methylates CDKN2A. 1 / 1
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sparser
"Forty-one of 98 MM patients (41.8%) as well as four of the five (80%) primary PCL patients showed methylation of the p16 gene, while none of the patients with monoclonal gammopathy of undetermined significance, Waldenström Macroglobulinemia or smoldering multiple myeloma displayed a methylation status."
p21 waf1 affects CDKN2A
| 1
P21 waf1 methylates CDKN2A. 1 / 1
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"These data would support a role for direct demethylation of these downstream target genes by 5-aza-dc as has previously been shown with the frequent methylation of p16 ink4a and p21 waf1 and cip1 in CRC [XREF_BIBR, XREF_BIBR]."
miR-217 affects CDKN2A
| 1
MiR-217 leads to the methylation of CDKN2A. 1 / 1
| 1
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"These data suggested that miR-217 induced a hypomethylation dependent increase in p16 and pRb expression, likely due to its effect on DNMT1 translation, leading to HSF senescence."
methyl affects CDKN2A
| 1
Methyl leads to the methylation of CDKN2A. 1 / 1
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"De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate and methyl deficiency in rats."
linE affects CDKN2A
| 1
LinE methylates CDKN2A. 1 / 1
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"Tumor was assessed for DNA methylation (by LINE assays), apoptosis, necrosis, mitoses, Ki67, DNA methyltransferase (DNMT1), CTR1, and p16."
ispF affects CDKN2A
| 1
IspF methylates CDKN2A. 1 / 1
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"Moreover, MeCPs bind to methylated promoters of MLH1, p16 (INK4a) and master cell cycle regulator and tumour suppressor BRCA1 and recruit repressive complexes that specifically repress target genes XREF_BIBR, XREF_BIBR."
inositol affects CDKN2A
| 1
Inositol leads to the methylation of CDKN2A. 1 / 1
| 1
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"MSI was associated with BRAF mutation, promoter methylation of hMLH1, APC and p16 (INK4A) and a high MI (total number of methylated genes) (P values : 2.4 x 10 (-2), 2.5 x 10 (-3), 1.8 x 10 (-2), 4.6 x 10 (-2) and 1.0 x 10 (-2), respectively)."
hydrogensulfite affects CDKN2A
| 1
Hydrogensulfite methylates CDKN2A. 1 / 1
| 1
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"First, we validated differential DNA methylation of the affected downstream CDKN2A region by bisulfite sequencing."
genistein affects CDKN2A
| 1
Genistein leads to the methylation of CDKN2A. 1 / 1
| 1
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"Genistein suppresses multiple cellular processes such as proliferation and angiogenesis by demethylating tumour suppressor genes p16, MGMT, GSTPi, RARbeta, and hMLH1."
folic acid affects CDKN2A
| 1
Folic acid leads to the methylation of CDKN2A. 1 / 1
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"At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p < 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p < 0.05)."
folate affects CDKN2A
| 1
Folate leads to the methylation of CDKN2A. 1 / 1
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"De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate and methyl deficiency in rats."
flavonol affects CDKN2A
| 1
Flavonol leads to the methylation of CDKN2A. 1 / 1
| 1
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"Flavonol quercetin from citrus fruits and buckwheat inhibited the proliferation of colon cancer RKO cells by reversing hypermethylation of the CDKN2A gene promoter DNA [XREF_BIBR, XREF_BIBR]."
death-associated protein affects CDKN2A
| 1
Death-associated protein leads to the methylation of CDKN2A. 1 / 1
| 1
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"The authors showed that rates of promoter methylation of p16, E-cadherin (CDH-1), and death associated protein kinase (DAPK) were significantly higher in noncancerous gastric mucosa of GC patients than in controls, and this was independent of other parameters."
cpg-1 affects CDKN2A
| 1
Cpg-1 methylates CDKN2A. 1 / 1
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sparser
"For every 10% increase in perinatal CDKN2A CpG1 methylation there was a decrease in %fat mass of 0.20 SD (95% CI − 0.33, − 0.06) age 4 years and 0.18 SD (− 0.31, − 0.05) age 6 years, controlling for sex."
cadmium atom affects CDKN2A
| 1
Cadmium atom methylates CDKN2A. 1 / 1
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"In lung fibroblast cells, Cd exposure resulted in an increased in DNA methylation of p16 and an upregulation of DNMT3b [XREF_BIBR]."
ZNF304 affects CDKN2A
| 1
ZNF304 leads to the methylation of CDKN2A. 1 / 1
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"Knockdown of ZNF304, KAP1, SETDB1 or DNMT1 also decreased p14 ARF promoter hypermethylation (XREF_FIG)."
XAF1 affects CDKN2A
| 1
XAF1 methylates CDKN2A. 1 / 1
| 1
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"Exposure to DAC for 48 h resulted in a dose dependent reversal of the hypermethylation of the p16 INK4A and XAF1 gene promoters as suggested by an increasing ratio of unmethylated to methylated (U/M) DNA (XREF_FIG)."
TCN1 affects CDKN2A
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TCN1 methylates CDKN2A. 1 / 1
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sparser
"HL-60 and T24 cancer cell lines were treated with azacitidine or decitabine in combination with HC and DNA methylation of LRE1, MAGEA1 and CDKN2A was quantitatively measured by bisulphite-polymerase chain reaction pyrosequencing."
SOCS1 affects CDKN2A
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SOCS1 methylates CDKN2A. 1 / 1
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"Our previous studies have shown that the hypermethylation of p16INK4a [XREF_BIBR] and suppressor of cytokine signaling 1 (SOCS1) [XREF_BIBR] were more likely to happen in male gender patients."
SGI-110 affects CDKN2A
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SGI-110 leads to the methylation of CDKN2A. 1 / 1
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"These authors further demonstrated that SGI-110 produced LINE-1 and p16 (a TSG) hypomethylation in a concentration dependent fashion, associated with robust re-expression of p16 mRNA and protein in both the human bladder carcinoma T24 cell line, as well as the human colon carcinoma HCT 116 cell line."
SETDB1 affects CDKN2A
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SETDB1 leads to the methylation of CDKN2A. 1 / 1
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"Knockdown of ZNF304, KAP1, SETDB1 or DNMT1 also decreased p14 ARF promoter hypermethylation (XREF_FIG)."
S100A9 affects CDKN2A
| 1
S100A9 methylates CDKN2A. 1 / 1
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sparser
"Methylation of p14(ARF) was often accompanied by p16(INK4a) methylation; however, 50% of p14(ARF) methylated tumors contained unmethylated p16(INK4a)."
RB1 affects CDKN2A
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RB1 methylates CDKN2A. 1 / 1
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sparser
"There were differences in p16(INK) (4a) -Rb immunotypes and INK4a/ARF methylation between two entities, indicating that cardia adenocarcinoma may be different in cell proliferation, differentiation, and gene biomarkers compared with distal gastric adenocarcinoma."
RASSF1A promoters affects CDKN2A
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RASSF1A promoters methylates CDKN2A. 1 / 1
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"Furthermore, since 5mTHF is involved in the supply of methyl groups to the remethylation cycle in which DNA is a terminal acceptor, FA may alter BC risk through altered epigenetic regulation of tumour suppressor genes as BC can involve hypermethylation of P16INK4a, BRCA1, BRCA2, oestrogen receptor (ER)-alpha, retinoic acid receptor-beta2, APC, and RASSF1A promoters leading to lower transcription and to impaired DNA repair."
RARbeta gene affects CDKN2A
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RARbeta gene methylates CDKN2A. 1 / 1
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"Soy flavonoids, genistein, biochanin A and daidzein, were shown to reverse DNA hypermethylation of CDKN2A, RARbeta, and MGMT genes in human esophageal squamous KYSE 510 carcinoma cells, as well as RARbeta gene in human prostate cancer LNCaP and PC-3 cells."
QMSP affects CDKN2A
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QMSP methylates CDKN2A. 1 / 1
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"In particular, detection of p16 (INK4a) methylation by QMSP may serve as a highly specific marker of pulmonary squamous cell carcinoma."
PTEN affects CDKN2A
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PTEN leads to the methylation of CDKN2A. 1 / 1
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"For example, mutation and promoter methylation of p16 and phosphatase and tensin homolog (PTEN) tumor suppressor genes have also been investigated in gastric cancer."
PAH affects CDKN2A
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PAH leads to the methylation of CDKN2A. 1 / 1
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"PAH exposure induced CpG site specific hypermethylation of p16 (INK4alpha) gene."
NUP214 affects CDKN2A
| 1
NUP214 leads to the methylation of CDKN2A. 1 / 1
| 1
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"There is increasing evidence that the hepatitis B X protein can induce methylation of p16 INK4A, supporting the close relationship between HCC and viral liver disease [XREF_BIBR]."
NPPA affects CDKN2A
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NPPA leads to the methylation of CDKN2A. 1 / 1
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"[Research on the growth inhibition of T47D cell and reversion of p16 hypermethylation by CDP]."
NFkappaB affects CDKN2A
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NFkappaB leads to the methylation of CDKN2A. 1 / 1
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"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
NADPH affects CDKN2A
| 1
NADPH leads to the methylation of CDKN2A. 1 / 1
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"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
MYC affects CDKN2A
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MYC methylates CDKN2A. 1 / 1
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sparser
"In addition, mutations in TP53, RB1, amplifications in MYC and promoter methylation of p16(INK4a) and BRCA2 have been reported in malignant PT and FA tumors ."
MS-UC-FRET affects CDKN2A
| 1
MS-UC-FRET methylates CDKN2A. 1 / 1
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"CDKN2A Methylation in Lung Cancer Tissue by MS-UC-FRET."
MBD4 affects CDKN2A
| 1
MBD4 methylates CDKN2A. 1 / 1
| 1
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"Furthermore, a chromatin immunoprecipitation assay clearly shows that MBD4 binds to hypermethylated promoters of the p16 (INK4a) and hMLH1 genes."
MAD2L1 affects CDKN2A
| 1
MAD2L1 leads to the methylation of CDKN2A. 1 / 1
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"The objective of this study was to investigate the role of promoter methylation of p16 (INK4A) and MAD2 genes in gastric marginal-zone B-cell lymphoma (MZBCL)."
LOH affects CDKN2A
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LOH methylates CDKN2A. 1 / 1
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"The study shows p16 inactivation in 28.3% (either by LOH or by p16 methylation)."
LD-MSP affects CDKN2A
| 1
LD-MSP methylates CDKN2A. 1 / 1
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"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
LAMTOR2 affects CDKN2A
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LAMTOR2 methylates CDKN2A. 1 / 1
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sparser
"Methylation of p14(ARF) was often accompanied by p16(INK4a) methylation; however, 50% of p14(ARF) methylated tumors contained unmethylated p16(INK4a)."
JNK affects CDKN2A
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JNK leads to the methylation of CDKN2A. 1 / 1
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"Inhibition of JNK with SP600125 prevented the PM induced increase in expression of DNMT1 protein (XREF_FIG) and p16 methylation in these cells (XREF_FIG)."
HMOX1 affects CDKN2A
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HMOX1 leads to the methylation of CDKN2A. 1 / 1
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"Silencing HO-1 sensitized SKM-1 cells toward AZA, which may be attributed to the influence of HO-1 on AZA induced p16 demethylation."
HMECs affects CDKN2A
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HMECs methylates CDKN2A. 1 / 1
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"This would agree with the finding that HMECs can rapidly methylate and suppress CDKN2a during culture."
HC and DNA affects CDKN2A
| 1
| 1
sparser
"HL-60 and T24 cancer cell lines were treated with azacitidine or decitabine in combination with HC and DNA methylation of LRE1, MAGEA1 and CDKN2A was quantitatively measured by bisulphite-polymerase chain reaction pyrosequencing."
H3K27 affects CDKN2A
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H3K27 methylates CDKN2A. 1 / 1
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"Moreover, Ezh2 mediates increased trimethylation of p16INK4a and p19Arf by H3K27, which epigenetically represses Ink4a and Arf production and contributes to proliferation of pancreatic beta cells."
H2AFY affects CDKN2A
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H2AFY leads to the methylation of CDKN2A. 1 / 1
| 1
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"[XREF_BIBR - XREF_BIBR] Interestingly, another study found that macroH2A1 can potentiate silencing, heterochromatin formation, and hypermethylation of the tumor suppressor p16 in CRC, but the work did not distinguish between macroH2A1.1 and macroH2A1.2."
GKN2 affects CDKN2A
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GKN2 methylates CDKN2A. 1 / 1
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sparser
"A total of 82 NHLs were examined for p16 methylation by Southern blot and PCR analysis."
GALR1 affects CDKN2A
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Methylated GALR1 leads to the methylation of CDKN2A. 1 / 1
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"GALR1 methylation is observed in primary HNSCC tumors and correlates with decreased GALR1 expression, as well as increased tumor size, lymph node status, tumor stage, CCND1 expression, p16 methylation, and survival."
FOXM1 affects CDKN2A
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FOXM1 leads to the methylation of CDKN2A. 1 / 1
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"Hence, whilst FOXM1 can induce promoter hypermethylation of p16 INK4A in " normal " cells, such effect may be perturbed in " cancer " cells."
FMN1 affects CDKN2A
| 1
FMN1 methylates CDKN2A. 1 / 1
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sparser
"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
FLT4 affects CDKN2A
| 1
FLT4 methylates CDKN2A. 1 / 1
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sparser
"Forty-one of 98 MM patients (41.8%) as well as four of the five (80%) primary PCL patients showed methylation of the p16 gene, while none of the patients with monoclonal gammopathy of undetermined significance, Waldenström Macroglobulinemia or smoldering multiple myeloma displayed a methylation status."
EX2 affects CDKN2A
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EX2 methylates CDKN2A. 1 / 1
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sparser
"The only exception was CDKN2A EX2 methylation in Asian subjects (p = 0.11), which may be related to the small sample size but will need to be further explored."
ESCE affects CDKN2A
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ESCE leads to the methylation of CDKN2A. 1 / 1
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"Interestingly, ESCE induced limited demethylation of RARB and CDKN2A genes, which is consistent with the inability of this extract to re-activate their expression."
EHMT2 affects CDKN2A
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EHMT2 methylates CDKN2A. 1 / 1
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sparser
"These immortalized (transformed) MSCs showed further enhanced DNA methylation of the p16(INK4a) gene by increased H3K9me."
E7 affects CDKN2A
| 1
E7 leads to the methylation of CDKN2A. 1 / 1
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"It is well known that E7 gene of HPV16 and 18 is involved in Rb inactivation and release of histone deacetylase (HDAC) from E2F-Rb and HDAC complex, enhancing P16INK4A hypermethylation through chromatin remodeling by HDAC XREF_BIBR."
DNMT3B affects CDKN2A
| 1
Modified DNMT3B leads to the methylation of CDKN2A. 1 / 1
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"These results strongly suggested that the involvement of HPV infection in nonsmoking female lung tumorigenesis may be mediated, at least to a certain extent, through the increase of DNMT3b protein expression to cause p16INK4a promoter hypermethylation."
CpG affects CDKN2A
| 1
CpG methylates CDKN2A. 1 / 1
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"XREF_BIBR Barrett et al XREF_BIBR demonstrated CpG hypermethylation of CDKN2A in seven progressor samples of a specific genetic clonality; however, no control group was analysed in parallel for this specific marker in this study."
COBRA affects CDKN2A
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COBRA methylates CDKN2A. 1 / 1
| 1
sparser
"For an independent confirmation of these results, we again deaminated genomic DNA and analysed p16 methylation by COBRA ( xref )."
CDKN1B affects CDKN2A
| 1
CDKN1B methylates CDKN2A. 1 / 1
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"We observed that hypermethylation of the p15INK4b, p16INK4a and p21cip1 promoters, but not the p27kip1 promoter, was partly correlated with markedly decreased mRNA expression."
CDKN1A affects CDKN2A
| 1
CDKN1A methylates CDKN2A. 1 / 1
| 1
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"These data would support a role for direct demethylation of these downstream target genes by 5-aza-dc as has previously been shown with the frequent methylation of p16 ink4a and p21 waf1 and cip1 in CRC [XREF_BIBR, XREF_BIBR]."
CDH1 affects CDKN2A
| 1
CDH1 leads to the methylation of CDKN2A. 1 / 1
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"The authors showed that rates of promoter methylation of p16, E-cadherin (CDH-1), and death associated protein kinase (DAPK) were significantly higher in noncancerous gastric mucosa of GC patients than in controls, and this was independent of other parameters."
CBX7 affects CDKN2A
| 1
CBX7 leads to the methylation of CDKN2A. 1 / 1
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"In consideration of above observation that CBX7 is downregulated in primary gastric carcinomas with p16 methylation and CBX7 knockdown does not induce demethylation of p16 in PC3 cells, it is likely that CBX7 upregulation may be sufficient for induction or maintenance of H3K9me3, but not for the establishment of DNA methylation within the p16 locus."
CASP8 affects CDKN2A
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CASP8 methylates CDKN2A. 1 / 1
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"Promoter methylation status : CASP8 : in 36/40 tumors methylated; TIMP3 : 1/38 methylated; MGMT 0/44 methylated; CDKN2A : 1/46 methylated; E-cadherin 3/36 methylated; no association between methylation status and clinical outcome."
BRAF affects CDKN2A
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BRAF-V600E leads to the methylation of CDKN2A. 1 / 1
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"V600E Braf induces CpG methylation of p16 INK4a."
ANRIL affects CDKN2A
| 1
ANRIL methylates CDKN2A. 1 / 1
| 1
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"ANRIL binds with PRC1 at the RNA binding domains of CBX7 and methylates the CDKN2A promoter region at H3K27, which inhibits CDKN2A gene expression."
5-methylphenazinium methyl sulfate affects CDKN2A
| 1
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"These results however are in good agreement with previous reports showing the hypermethylation of tumor suppressor p16 by PMs from urban areas, which could lead to cancer development 39 and the induction of lung carcinoma by Mo inhalation exposure in mice."
5-aza-2'-deoxycytidine affects CDKN2A
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5-aza-2'-deoxycytidine leads to the methylation of CDKN2A. 1 / 1
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"In vitro, decitabine was shown to reverse the inactivation of p16 in lung cancer cell lines by removing the transcriptional block of p16 methylation."
(-)-epigallocatechin 3-gallate affects CDKN2A
| 1
(-)-epigallocatechin 3-gallate leads to the methylation of CDKN2A. 1 / 1
| 1
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"EGCG has been shown to cause promoter hypomethylation of p16, RARbeta2, MGMT, hMLH1, WIF-1, GSTP1 and RECK genes across different cancer types and has been reviewed extensively (Singh et al., 2013)."