"Several reports have claimed predictive value ofp16 INK4a methylation ( xref , xref – xref , xref , xref , xref ) which we could not replicate in our cohort."
"However, there was no difference in promoter methylation in the ERalpha, ERbeta and p16 genes."
"p16 methylation was relatively common in PCM, but did not influence the survival outcome."
"CDKN2A has been proved to bear a striking resemblance to classic TSGs such as p53 , and to be an important negative regulator of cell growth and proliferation. xref It is largely reported that a critical mechanism for silencing CDKN2A is hypermethylation of its regulatory region. xref Abnormal methylation of the CDKN2A gene is a common event in many types of human cancer, as well as in cervical cancer. xref , xref – xref However, conclusions regarding the role of methylated CDKN2A during the carcinogenesis of cervical cancer are inconsistent."
"All cases with p16 methylation had experienced more than 15 years of chromate exposure."
"PCR revealed p16 methylation and no alteration in p53."
"The results demonstrated that the P16 , RASSF1A and APC methylation with low sensitivity (< 0.5) and AUC (< 0.8) could not distinguish lung cancer and non-tumor samples well."
"Of the nine genes which we studied, only methylation of CDKN2A and RUNX3 appeared to increase in frequency in the progression from BE to cancer, and only six of the nine genes increased in the extent of methylation."
"After 10 days of treatment, we isolated the DNA from the cells for measurement p16 promoter methylation."
"As shown in the Figure xref , Fagan plot analysis demonstrated that the probabilities of a patient being diagnosed with EC were 82%, 93%, and 98% following a positive result for methylation of CDKN2A , where the pretest probabilities of being diagnosed with EC were set to 25%, 50%, and 75%, respectively; when the test was negative, the probabilities of diagnosis with EC reduced to 14%, 33%, and 60%, respectively."