IndraLab

Statements

CDKN2A is modified
| 1 5556
CDKN2A is methylated. 10 / 5556
| 1 5555
sparser
"CDKN2A has been proved to bear a striking resemblance to classic TSGs such as p53 , and to be an important negative regulator of cell growth and proliferation. xref It is largely reported that a critical mechanism for silencing CDKN2A is hypermethylation of its regulatory region. xref Abnormal methylation of the CDKN2A gene is a common event in many types of human cancer, as well as in cervical cancer. xref , xref – xref However, conclusions regarding the role of methylated CDKN2A during the carcinogenesis of cervical cancer are inconsistent."
27574435
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"Total DNA methylation and promoter-specific methylation of the two tumor suppressor genes, p14ARF and p15INK4b , were performed employing the DNA derived from 40 petrochemical employers subjected to ambient benzene concentrations of <1 ppm, and 31 office employers not subjected to benzene."
34069279
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"After 10 days of treatment, we isolated the DNA from the cells for measurement p16 promoter methylation."
22355787
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"The present study investigated the rate of p16 gene promoter methylation and the protein expression levels of p16, cyclin D1, CDK4, Rb and E2F1 in LFs from the lungs of rats exposed to hyperoxia and normoxia on postnatal days 3, 7 and 14."
34434271
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"Methylation of p16INK4A was examined using methylation specific polymerase chain reaction (PCR) (MSP)."
24665436
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"Conclusion suggested that there were high incidence of methylation of p15(INK4B) and p16(INK4A) genes in patients with MM."
12578664
sparser
"The difference of CDKN2A-methylation and p16 protein expression between HCCs and liver metastases was statistically significant (p < 0.01, respectively)."
20569442
sparser
"It has been observed that there was a significant inverse correlation between p16 hyper methylation and P53 expression in a sample of Iranian esophageal squamous cell carcinoma (ESCC) patients [ xref ]."
33883026
sparser
"The p16 methylation status and the presence of p16 protein were analyzed by methylation-specific PCR and immunohistochemistry, respectively."
12547284
sparser
"Methylation of p16, IGFBP7, MLH1 and MINT1, -2, -12 and -31 was analyzed using bisulfite pyrosequencing."
22233696
CDKN2A is methylated on arginine. 1 / 1
| 1
sparser
"Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues."
26622834
CXXC1 affects CDKN2A
| 72
CXXC1 methylates CDKN2A. 10 / 65
| 65
sparser
"Southern blots showed methylation of p15 at one CpG site in an Eag I site, and no methylation of p16 at one CpG site in a Sac II site."
11532526
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"In genome analysis, the CpG methylation of p16 (cyclin-dependent kinase inhibitor 2A) is observed in all ameloblastic carcinoma samples, but only one ameloblastoma specimen exhibits the mutation."
24799899
sparser
"Pyrosequencing provided a sensitive tool for detecting CpG promoter methylation of CDKN2A gene and allowed quantitative assessment of the degree of methylation, because tumor samples often represent[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25542698
sparser
"Matrix-assisted laser desorption ionization-time of flight mass spectrometry was applied to detect methylation of CpG sites in the promoter region of the P16 gene; polymerase chain reaction was performed to assess HPV16 infection in the 2 groups."
25222242
sparser
"In addition to mutation and homozygous deletions, frequent 5′-CpG island methylation of CDKN2A gene resulting in transcriptional silencing of this gene is noted as an important event in the development of EC."
26283007
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"Thus, there were no significant differences in the methylation of all the 7 CpG sites of p16 gene."
29019900
sparser
"Accordingly, the investigators observed the CpG methylation of p16 in all collected ameloblastic carcinoma specimens."
22705216
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"The overall genome CpG methylation and promoter methylation of PTEN and CDKN2A were unaffected in the lesions."
25229773
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"The low frequency of p16 Ink4a CpG methylation found could therefore be explained by the occurrence of methylation po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11163109
sparser
"Of 12 HCCs with lower p16 mRNA expression level, 11 cases showed p16 promoter CpG islands methylation (91.6%)."
15112341
CXXC1 methylates CDKN2A. 7 / 7
| 7
sparser
"To this end, we mixed gDNA of HCT116 (one copy of each CpG-methylated and unmethylated CDKN2A (p16) ) and 293T (two copies of unmethylated CDKN2A (p16) ), so that the CpG-methylated CDKN2A (p16) accounted for 5–0.05% of total CDKN2A (p16) , and then subjected them to bisulfite treatment."
32698480
sparser
"CpG island methylation in p16 Ink4a was observed in a subset of BRAF V637E -induced serrated adenomas with dysplasia and carcinomas [ xref ]."
31735291
sparser
"In ameloblastic carcinoma, aberrant CpG island methylation of p16 was identified however there were no mutational alterations in p53 exons 5–8 [ xref ]."
35048074
sparser
"ORNi-PCR with ORN_p16_U and ORN_p16_M strongly suppressed the amplification of the target CDKN2A (p16) sequence from bisulfite-treated unmethylated and CpG-methylated human gDNA, respectively, as shown in xref A. Amplification from bisulfite-treated HCT116 gDNA was moderately suppressed by each ORN, probably due to the hemi-allelic CpG methylation of CDKN2A (p16) ."
32698480
sparser
"Effect of VPA/hydralazine on CpG island methylation of CDKN2A in mammary tumors."
31889127
sparser
"Conclusions: Our results indicate that carrying the minor allele of the MAFK polymorphisms, particularly when they are located in the 3'-UTR, has a high risk for the severity of gastric mucosal atrophy; furthermore, CDKN2A CpG methylation may develop in subjects with homozygous minor allele of these polymorphisms."
33877894
sparser
"In HCT116 cells, the CDKN2A (p16) genes are CpG-methylated in one allele but not in the other allele (i.e., there exist one copy of CpG-methylated and another copy of unmethylated CDKN2A (p16) gene) [ xref ]."
32698480
CDKN2A affects CDKN2A
| 19 38
CDKN2A methylates CDKN2A. 10 / 56
| 18 38
sparser
"The absence of p14 protein in cell lines with p14 methylation and re-expression of transcriptionally silenced p14 after treatment with 5-aza-2′-deoxycytidine confirms that the signal is attributable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11839577
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"CDKN2A methylation and loss of CDKN2A (p16) in colorectal cancer."
20473920
sparser
"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
28256616
sparser
"Every 1 μg/m 3 increase of PM 10 resulted in 0.01% and 0.02% decrease of LINE - 1 and iNOS methylation, and 0.029% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% decrease of iNOS promoter methylation in lung tissue DNA, and 0.18 and 0.19 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
28256616
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"However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p16) expression independent of CIMP status remains uncertain."
20473920
sparser
"We therefore evaluated the prognostic role of CDKN2A promoter methylation and loss of CDKN2A (p16) independent of CIMP status, utilizing the database of a large number (N=902) of clinically and molecularly-annotated colorectal cancers."
20473920
sparser
"Methylation of p14(ARF) was often accompanied by p16(INK4a) methylation; however, 50% of p14(ARF) methylated tumors contained unmethylated p16(INK4a)."
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"To validate prediction data on the p16 nucleosome occupancy in the human genome (XREF_FIG) XREF_BIBR, we characterized nucleosome position within p16 CpG island in the p16 methylated human GC cell line AGS and the p16 unmethylated cell line MGC803 (detected by 392 bp DHPLC) using the mono-nucleosomal DNA as the template."
22558275
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"Nonetheless, it is unlikely that chemotherapy use substantially differed according to CDKN2A methylation or loss of CDKN2A (p16) in tumor, since such data were not available for treatment decision making."
20473920
sparser
"Sex could interact with PM 2.5 in affecting blood APC promoter methylation, interact with PM 10 in affecting lung tissue LINE - 1 methylation, and interact with PM 2.5 in affecting lung tissue p16 CDKN2A promoter methylation ( xref )."
28256616
Methylated CDKN2A leads to the methylation of CDKN2A. 1 / 1
| 1
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"The higher frequency of p16 hypermethylation in HBV associated CNs, DNs and HCCs may thus support the role of the HBV in p16 hypermethylation."
12565176
ARF affects CDKN2A
| 28
ARF methylates CDKN2A. 10 / 28
| 28
sparser
"Association ofp16 INK4A andp14 ARF methylation and tumor grade in cancer."
28969078
sparser
"Although some studies involvingp16 INK4A andp14 ARF promoter methylation included patients with RCC, the studies published in this field have had small sample sizes."
28969078
sparser
"More studies with sufficient data are necessary to further evaluate the prognostic value ofp16 INK4A andp14 ARF promoter methylation in RCC."
28969078
sparser
"Prognostic value ofp16 INK4A andp14 ARF gene promoter methylation in RCC."
28969078
sparser
"Association ofp16 INK4A andp14 ARF methylation and lymph node status in cancer."
28969078
sparser
"Analysis of the pooled OR showed thatp16 INK4A andp14 ARF promoter methylation were significantly higher in patients with RCC than in control subjects, suggesting thatp16 INK4A andp14 ARF inactivation via promoter methylation may play an important role in the tumorigenesis of RCC."
28969078
sparser
"The pooled OR from seven studies and from three studies suggested thatp16 INK4A andp14 ARF promoter methylation was not significantly correlated with tumor grade in RCC (OR = 1.20, 95% CI = 0.58-2.45, P = 0.625; OR = 2.13, 95% CI = 0.96-4.75, P = 0.063, respectively) (Table xref )."
28969078
sparser
"In addition, our findings showed thatp16 INK4A andp14 ARF promoter methylation were not significantly associated with tumor grade, tumor stage, and lymph node status."
28969078
sparser
"Of these studies, which involvedp16 INK4A andp14 ARF gene promoter methylation, nine studies evaluated the association betweenp16 INK4A promoter methylation and RCC risk, five studies assessed the correlation betweenp14 ARF promoter methylation and RCC risk, ten studies evaluated the relation betweenp16 INK4A promoter methylation and clinicopathological features, and four studies evaluated the relation betweenp14 ARF promoter methylation and clinicopathological features."
28969078
sparser
"Although numerous studies have been conducted to evaluate the role ofp16 INK4A andp14 ARF promoter methylation in RCC, the results are still inconsistent and controversial."
28969078
PRMT6 affects CDKN2A
| 5 6
PRMT6 methylates CDKN2A. 4 / 4
| 2 2
sparser
"PRMT6 methylates p53, p21, and p16, involving in regulation of cell proliferation, cell-cycle arrest, senescence, and apoptosis [ xref , xref , xref ]."
33260152
sparser
"In addition to suppressing the expression of the cell cycle inhibitors p16 and p21 through epigenetic modifications [ xref , xref ], PRMT6 also methylates p16 and p21 and negatively regulates their functions."
| PMC
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"PRMT6 also directly methylates and inhibits the activity of tumor suppressor p16 (INK4A) [52]."
24742914
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"PRMT6 methylates p53, p21, and p16, involving in regulation of cell proliferation, cell-cycle arrest, senescence, and apoptosis [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
33260152
PRMT6 methylates CDKN2A on R22. 2 / 2
| 1 1
sparser
"PRMT6 methylates p16 at Arg22, Arg131 and Arg138 residues and promotes the cell cycle by inhibiting the interaction of p16 with CDK4 [ xref , xref ]."
| PMC
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
28120917
PRMT6 methylates CDKN2A on R131. 2 / 2
| 1 1
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
28120917
sparser
"PRMT6 methylates p16 at Arg22, Arg131 and Arg138 residues and promotes the cell cycle by inhibiting the interaction of p16 with CDK4 [ xref , xref ]."
| PMC
PRMT6 methylates CDKN2A on R138. 2 / 2
| 1 1
sparser
"PRMT6 methylates p16 at Arg22, Arg131 and Arg138 residues and promotes the cell cycle by inhibiting the interaction of p16 with CDK4 [ xref , xref ]."
| PMC
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"Recently, we have demonstrated that p16 are methylated at Arg 22, Arg 131 and Arg 138 by PRMT6 and these modifications alleviated the cell cycle arrest at G1 via reducing p16-CDK4 interaction XREF_BIBR."
28120917
PRMT6 methylates CDKN2A on arginine. 1 / 1
| 1
sparser
"Together, data presented in this report establish that methylation at specific arginine residues of p16 protein by PRMT6 may be critical for the activity of p16."
23032699
DNMT1 affects CDKN2A
| 8 3
DNMT1 methylates CDKN2A. 10 / 10
| 7 3
sparser
"In consistent with this hypothesis, we found that P16 methylation by P16-Dnmt directly increased the paclitaxel IC50 value of BGC823 cells, whereas reactivation of P16 demethylation by P16-TET directly decreased the IC50 in H1299 cells."
31205528
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"DNMT1 has been shown to be specifically over-expressed in NSCLC lung tumours compared to normal cells where DNMT1 over-expression resulted in increased methylation of the TSGs, FHIT, p16 INK4a and RARbeta 21."
29559689
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"DNMT1 siRNA induces demethylation of the tumor suppressor genes SOCS1 and p16."
25289094
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"Notably, P16 -specific methylation by P16-Dnmt directly increased the sensitivity of lung cancer cells to palbociclib in vitro and in vivo ."
31652270
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"Uropathogenic E. coli infection induces de novo methyltransferase activity and DNMT1 expression causing increased methylation of CDKN2A exon 1 and downregulation of this tumor suppressor gene in uroepithelial cells, which may increase the risk of bladder cancer."
34394088
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"In a multivariate analysis, CIMP and MLH1 and CIMP and p16 INK4a methylation statuses were predictive of prognosis, and the OS was longer for patients with tumors CIMP- and MLH1-M, as well as CIMP- and p16 INK4a -M. Furthermore, DNMT1 is significantly overexpressed in tumors than in normal tissues as well as in CIMP+ than CIMP- tumors."
28730335
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"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
24025864
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"Regulation of DNMT1 and DNMT3A by HBx promoted hypermethylation of p16 (INK4A) promoter region."
20620135
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"Based on multiple gene expression analysis (MGEA) using type 1, type 2, and pancreatic intraductal papillary mucinous neoplasms (n=4, 6, and 5, respectively), immunohistochemistry of DNMT1 and methylation-specific PCR for p16, APC, BRCA1, hMLH1, TIMP3, and SOX17 were performed on type 1 and 2 IPNBs (n=14, each)."
35641291
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"In contrast, P16 -specific methylation by P16-Dnmt significantly increased paclitaxel resistance of lung cancer HCC827 cells and gastric cancer BGC823 cells (IC50 values increased from 18.2 to 24.0 ng/ml and 0.18 to 0.81 µg/ml, respectively; P =0.049 and <0.001, respectively)."
31205528
Modified DNMT1 leads to the methylation of CDKN2A. 1 / 1
| 1
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"Besides the role played by the DNMT family in DNA hypermethylation and tumorigenesis, supression of DNMT1 expression in bladder cancer cells was shown to induce demethylation and reactivation of the silenced tumor suppressor gene CDKN2A."
22481891
MST1 affects CDKN2A
| 4 6
MST1 methylates CDKN2A. 10 / 10
| 4 6
sparser
"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
17595762
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"Because inactivation of the INK4a locus by promoter hypermethylation has been demonstrated in primary tumors from both human and rodents [3,5,25,27] , we examined these murine lung tumors for methy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11595130
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"Unfortunately, the p16 INK4a transcriptional activation and HR-HPV-E7 oncogene expression were not analyzed in most of the studies demonstrating methylation of p16 INK4a by MSP in some portion of cervical carcinomas [XREF_BIBR - XREF_BIBR]."
17359536
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"We detected methylation of p16 (INK4A) (17/43), p14 (ARF) (11/42) and TIMP3 (9/44) in MB and others by MSP."
17206475
sparser
"Unfortunately, the p16 INK4a transcriptional activation and HR-HPV-E7 oncogene expression were not analyzed in most of the studies demonstrating methylation of p16 INK4a by MSP in some portion of cervical carcinomas [ xref - xref ]."
17359536
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"We detected methylation of p16 (INK4A) (17/43), p14 (ARF) (11/42) and TIMP3 (9/44) in MB and others by MSP."
17206475
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"In the present study, we have, however, found that betaine had no effect on methylation of p16 or c-myc by MSP and there were no differences in c-myc methylation among the five groups of rats."
19642983
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"Detection of hypermethylated CDKN2A by MSP does not show potential for CRC detection considering its low sensitivity."
32328554
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"The MAGE -positive group in sputum showed a statistically significant higher MAGE A3 unmethylation and p16 MSP methylation rate than the MAGE negative group."
22134685
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"Fig xref shows the results of p16 promoter DNA methylation by MSP."
19642983
Arsenic atom affects CDKN2A
6 |
Arsenic atom methylates CDKN2A. 6 / 6
6 |
ctd
No evidence text available
23872714
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No evidence text available
24525453
ctd
No evidence text available
22466225
ctd
No evidence text available
23073540
ctd
No evidence text available
16251483
ctd
No evidence text available
25598836
All-trans-retinoic acid leads to the methylation of CDKN2A. 6 / 6
| 6
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"Consistently, ATRA downregulated levels of DNMT 1 and 3b, induced promoter hypomethylation of p16, facilitated recruitment of Ets1/2 transcriptional activators to the p16 promoter, and enhanced the p1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23474497
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"Therefore, we conclude that ATRA induces p14 promoter hypomethylation to trigger apoptosis."
25827071
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"Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells."
21843507
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"Combination treatment of ATRA and DAC induced DNA hypomethylation as well as gene expression of p16 and RARbeta, which contributed to the growth inhibition, differentiation, apoptosis and cell cycle arrest of U937 cells."
30111392
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"In addition, ATRA downregulated levels of DNMT1 and induced promoter hypomethylation of p16 and RAR-beta 2, resulting in activation of their expression in the control cells."
23474497
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"Consistently, ATRA downregulated levels of DNMT1 and 3b and induced promoter hypomethylation of p16 and RAR-beta 2, resulting in activation of their expression in the HepG2 cells without Core expressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23474497
GNAS affects CDKN2A
| 6
GNAS methylates CDKN2A. 6 / 6
| 6
sparser
"Because the INK4 gene is frequently inactivated by de novo methylation, we investigated the frequency of INK4a exon 1alpha methylation in a subset of 120 primary breast cancers using methylation-specific PCR; 24 of these were methylated."
10914724
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"Out of 50 lung cancer tissues, 16 were positive for the p16 gene exon 1 methylation (32.0%), and 14 for the p16 gene exon 2 deletion (28.0%)."
21329582
sparser
"Nguyen and colleagues 31 reported a high frequency of p16 INK4a exon 2 methy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11943705
sparser
"However, in 54 cases of normal lung tissues, only 2 showed the p16 gene exon 1 methylation(3.7%), and none showed the p16 gene exon 2 deletion."
21329582
sparser
"The functional consequences of CDKN2A exon 2 DNA methylation in tumor samples merits further investigation."
21731750
sparser
"Since Herman et al xref first reported inactivation of CDKN2A by DNA methylation in prostate cancer, other researchers have investigated the role of hypermethylated CDKN2A in the carcinogenesis and progression of prostate cancer. xref , xref – xref , xref – xref Although there was no significant association between CDKN2A low expression and increased CDKN2A exon 2 methylation, the exon 2 methylation may be a potential biomarker for prostate tumor. xref These results were confirmed by other investigators."
20861812
CDKN2B affects CDKN2A
| 3 2
CDKN2B methylates CDKN2A. 5 / 5
| 3 2
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"Accumulating evidence suggests an almost universal inactivation of the RB pathway in HCC, including by promoter hypermethylation of the p16 INK4a (~ 50% of cases) or p15 INK4b (~ 15% of cases) genes, and amplification of the gene coding for Cyclin D1 (~ 30% of cases)."
21875955
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"Their results indicated that the rates ofp15 INK4B andp16 INK4A promoter methylation in MM samples were significantly higher compared with normal controls."
25382971
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"In RRP Case 5, aberrant methylation of BRAC2, APC and CDKN2A in the reference papilloma biopsy and CDKN2B in biopsy 2 were also identified in the subsequent progression lesions (XREF_TABLE)."
22388100
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"In RRP Case 5, aberrant methylation of BRAC2, APC and CDKN2A in the reference papilloma biopsy and CDKN2B in biopsy 2 were also identified in the subsequent progression lesions (XREF_TABLE, XREF_FIG)."
21603083
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"Another intriguing observation in our study was the positive significant correlation between ANRIL exon 1–5 expression andp15 INK4b andp16 INK4a methylation (r = 0.23, p = 0.001 and r = 0.24, p = 0.001, respectively)."
23091611
HMLH1 affects CDKN2A
| 4
HMLH1 leads to the methylation of CDKN2A. 4 / 4
| 4
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"EBV-infection in cardiac and non cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1."
21538028
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"EBV-infection in cardiac and non cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1."
21538028
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"EBV-Infection in Cardiac and Non Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1."
20978327
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"EBV-Infection in Cardiac and Non Cardiac Gastric Adenocarcinomas is Associated with Promoter Methylation of p16, p14 and APC, but not hMLH1."
20978327
X affects CDKN2A
| 3 1
X leads to the methylation of CDKN2A. 4 / 4
| 3 1
sparser
"The HBx can induce p16 gene promoter methylation and inhibit the expression of p16 in HepG2 cells."
36482819
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"Moreover, HBx induces hypermethylation of p16 (INK4A) promoter through DNMT1 and DNMT3A."
20620135
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"HBx induced DNA hypermethylation of p16 (INK4a) promoter to repress its expression, which subsequently led to activation of G1-CDKs, phosphorylation of pRb, activation of E2F1, and finally transcriptional activation of DNMT1."
17575144
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"DNMT1 and DNMT3A may play important roles in the process of HBx inducing hypermethylation of the p16 (INK4A) promoter in the early stages of HBV associated HCC."
19732323
TP53 affects CDKN2A
| 4
TP53 methylates CDKN2A. 2 / 2
| 2
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"There were no statistically significant differences in age or gender in the methylation of p14 ARF, DAPK, and TMS1 and ASC or p53 gene mutation on p53-Bax mitochondrial apoptosis pathway."
22230750
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"Beyond global methylation alterations, several recent epidemiologic studies have reported positive gene specific associations between in utero exposure to arsenic and promoter methylation of CDKN2A (encoding p16INK4A) and TP53 measured in human umbilical cord peripheral blood lymphocytes (PBLs)."
23757598
Modified TP53 leads to the methylation of CDKN2A. 1 / 1
| 1
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"6 Reported molecular and genetic alterations in MCN of the pancreas include mutations in KRAS (V-Ki-ras2, Kirsten rat sarcoma viral oncogene homolog) oncogene 7 and DPC4 and SMAD4 (deleted in pancreatic cancer locus 4 protein) gene, XREF_BIBR, XREF_BIBR promoter hypermethylation of p16 ink4a / CDKN2A (inhibitor of cyclin dependent kinase 4/cyclin dependent kinase inhibitor 2A), and aberrant p53 protein expression."
24518503
Mutated TP53 leads to the methylation of CDKN2A. 1 / 1
| 1
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"Correlation between promoter methylation of p14 ARF, TMS1 and ASC, and DAPK, and p53 mutation with prognosis in cholangiocarcinoma."
22230750
MS-MLPA affects CDKN2A
| 4
MS-MLPA methylates CDKN2A. 4 / 4
| 4
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"MSP confirmed MS-MLPA methylation of BRCA2 (biopsy 1), APC (biopsy 4), GSTP1 (biopsy 6), and CDKN2A (biopsies 5 and 6)."
22388100
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"MSP confirmed MS-MLPA methylation of BRCA2 (biopsy 1), APC (biopsy 4), GSTP1 (biopsy 6), and CDKN2A (biopsies 5 and 6)."
21603083
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"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
21603083
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"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
22388100
Dioxygen affects CDKN2A
| 3
Dioxygen leads to the methylation of CDKN2A. 3 / 3
| 3
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"Of interest, high PlGF expressing tumors such as choriocarcinoma also have hypermethylation of p16ink4a, which may be mediated by the reactive oxygen species mediated pathway for regulation of PlGF expression."
26601163
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"Reactive oxygen induced carcinogenesis causes hypermethylation of p16 (Ink4a) and activation of MAP kinase."
11984000
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"Our conclusions from this is that reactive oxygen induced carcinogens cause hypermethylation of p16ink4a and MAP kinase activation."
22581366
Vehicle Emissions methylates CDKN2A. 3 / 3
3 |
ctd
No evidence text available
11872642
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26778509
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25560391
Tobacco Smoke Pollution methylates CDKN2A. 3 / 3
3 |
ctd
No evidence text available
12117769
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No evidence text available
19375815
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No evidence text available
25214829
TRAP affects CDKN2A
| 3
TRAP leads to the methylation of CDKN2A. 3 / 3
| 3
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"These findings suggest that rapid TRAP exposure may not be sufficient to increase p16 CDKN2A gene promoter methylation, which could be associated with the powerful clearance ability of the respiratory system."
28256616
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"In contrast, prolonged TRAP exposure could effectively induce p16 CDKN2A gene hypermethylation, thus reduce p16 CDKN2A gene expression, affect cell cycle, and finally play an important role in the development of multiple pulmonary diseases."
28256616
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"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
28256616
NSUN2 affects CDKN2A
| 2
NSUN2 methylates CDKN2A. 2 / 3
| 2
sparser
"In vitro methylation assays show that NSun2 methylates the p16 3′UTR at A988."
22395603
sparser
"NSun2 methylates the p16 3’UTR at A988."
22395603
MGMT affects CDKN2A
| 3
MGMT methylates CDKN2A. 3 / 3
| 3
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"The present study examined aberrant hypermethylation of p16, DAPK, RASSF1A, APC, WIF1, RUNX3, E-cad, MGMT and hMLH1 genes in histologically negative surgical margins of OSCC patients, and their associ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21697000
reach
"Furthermore, promoter methylation of both CDKN2A (p14ARF) and MGMT has been associated with tumour stage and the addition of GSTP1 and TIMP3 promoter methylation allowed to discriminate invasive tumours [112]."
30149597
reach
"Lin et al. (2005) analyzed the methylation of the genes p16 INK4a and MGMT in LSIL and found methylation rates of 20% and 30%, respectively."
25579180
Histone affects CDKN2A
| 2 1
Histone methylates CDKN2A. 3 / 3
| 2 1
sparser
"Histone methylation in APC, INK4a, and MLH has been frequently observed in sporadic colon cancer: APC and INK4a are tumor suppressor genes and MLH controls DNA stability ( xref – xref )."
27110580
reach
"Moreover, hypermethylation mediated silencing of p14 (ARF) expression [XREF_BIBR] and decreased Fas expression by histone modifications (methylation and acetylation) [XREF_BIBR] have also been proposed as a mechanism of IPF lung fibroblast resistance to apoptosis."
24746870
reach
"These studies for the first time link Twist-1 to histone methylation of the Ink4A and Arf locus by controlling the expression of histone methyltransferases as well as the expression of other bHLH factors."
22290439
EZH2 affects CDKN2A
| 2 1
EZH2 leads to the methylation of CDKN2A. 3 / 3
| 2 1
reach
"The knockdown of EZH2 in cultured CC cells decreased p16 INK4a methylation and decreased binding of EZH2 to the p16 INK4a gene promoter."
18393368
reach
"Ezh2 knockdown with shRNA eliminated H3K27me mediated DNA methylation of the p16 (INK4a) gene in presenescent MSCs, but had no effect on H3K9me enhanced DNA hypermethylation in the cells after senescence escape."
22873822
sparser
"The authors concluded from their study that EZH2-dependent histone methylation and repression of the Ink4a / Arf locus are required for β-cell expansion [ xref , xref ]."
33401659
APC affects CDKN2A
| 1 2
APC methylates CDKN2A. 3 / 3
| 1 2
reach
"Furthermore, since 5mTHF is involved in the supply of methyl groups to the remethylation cycle in which DNA is a terminal acceptor, FA may alter BC risk through altered epigenetic regulation of tumour suppressor genes as BC can involve hypermethylation of P16INK4a, BRCA1, BRCA2, oestrogen receptor (ER)-alpha, retinoic acid receptor-beta2, APC, and RASSF1A promoters leading to lower transcription and to impaired DNA repair."
27293554
sparser
"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
28256616
sparser
"After sex, season, SO 2 level, temperature, and age were adjusted, the results showed that every 1 μg/m 3 increase of PM 2.5 resulted in 0.04% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% and 0.06% decrease of LINE - 1 and iNOS methylation in lung tissue DNA, 0.01% and 0.01% increase of APC and p16 CDKN2A promoter methylation in lung tissue DNA, and 0.64 and 0.66 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
28256616
AADAC affects CDKN2A
| 3
AADAC leads to the methylation of CDKN2A. 3 / 3
| 3
reach
"To further understand how DAC causes hypomethylation of the p16 INK4A and XAF1 genes we examined the status of DNA methyl transferase (DNMT) isozymes which are known to catalyze DNA methylation."
19732952
reach
"Combination treatment of ATRA and DAC induced DNA hypomethylation as well as gene expression of p16 and RARbeta, which contributed to the growth inhibition, differentiation, apoptosis and cell cycle arrest of U937 cells."
30111392
reach
"In spite of CDKN2A hypomethylation induced by DAC, there was n't any change in the expression level of the gene (XREF_FIG)."
22076154
5-aza-2'-deoxycytidine leads to the methylation of CDKN2A. 3 / 3
2 | 1
reach
"In vitro, decitabine was shown to reverse the inactivation of p16 in lung cancer cell lines by removing the transcriptional block of p16 methylation."
23755372
ctd
No evidence text available
30259626
ctd
No evidence text available
17938735
Valproic acid affects CDKN2A
1 | 1
Valproic acid leads to the methylation of CDKN2A. 2 / 2
1 | 1
reach
"Unexpectedly, VPA/hydralazine treatment significantly increased methylation of Cdkn2a in introns 1 and 2."
31889127
ctd
No evidence text available
29154799
Nickel(2+) affects CDKN2A
| 2
Nickel(2+) leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"Methylation of RAR-beta2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats."
21565688
reach
"Nickel was found to promote gene specific hypermethylation of the tumor suppressor p16 in several studies."
29967663
Lpp affects CDKN2A
| 2
Lpp methylates CDKN2A. 2 / 2
| 2
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1–3)."
21603083
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
22388100
Hydralazine affects CDKN2A
| 2
Hydralazine leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"While not statistically significant, VPA/hydralazine decreased the elevated DNA methylation of Cdkn2a in both the promoter region and 1 exon in HF group (Fig. 5)."
31889127
reach
"Unexpectedly, VPA/hydralazine treatment significantly increased methylation of Cdkn2a in introns 1 and 2."
31889127
Cadmium dichloride methylates CDKN2A. 2 / 2
2 |
ctd
No evidence text available
25448810
ctd
No evidence text available
17938735
Cadmium atom affects CDKN2A
1 | 1
Cadmium atom methylates CDKN2A. 2 / 2
1 | 1
ctd
No evidence text available
17938735
reach
"In lung fibroblast cells, Cd exposure resulted in an increased in DNA methylation of p16 and an upregulation of DNMT3b [XREF_BIBR]."
29349066
Bisphenol A affects CDKN2A
2 |
Bisphenol A methylates CDKN2A. 2 / 2
2 |
ctd
No evidence text available
22258036
ctd
No evidence text available
28505145
WIZ affects CDKN2A
| 2
WIZ methylates CDKN2A. 2 / 2
| 2
sparser
"Methylation status of INK4a-ARF locus The CpG WIZ p16 Methylation Assay Kit was used (OncorInc, Gaithersburg, MD, USA) [33] according to the manufacturer’s description."
12924439
sparser
"The methylation status of the 5′ CpG island in the promoter region of the p16 gene was determined with the CpG Wiz p16 Methylation kit (Oncor, Gaithersburg, MD), based on the method developed by Herma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10393843
TWSG1 affects CDKN2A
| 2
TWSG1 methylates CDKN2A. 2 / 2
| 2
sparser
"Until now, p16 tumor suppressor gene promoter methylation has been the most studied [ xref ]."
11980589
sparser
"Data related to epigenetics of salivary gland tumors including p16 and p14 TSG methylation status are very scarce."
26351750
RB1 affects CDKN2A
| 1 1
RB1 methylates CDKN2A. 2 / 2
| 1 1
reach
"Therefore, these data support the notion that the re-expressed p16INK4A, induced by 5-AZA/decitabine, restored a functional pRB pathway.Hypermethylation of p16INK4A has been reported in various cancer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11098088
sparser
"There were differences in p16(INK) (4a) -Rb immunotypes and INK4a/ARF methylation between two entities, indicating that cardia adenocarcinoma may be different in cell proliferation, differentiation, and gene biomarkers compared with distal gastric adenocarcinoma."
25123601
RARB affects CDKN2A
| 1 1
RARB leads to the methylation of CDKN2A. 2 / 2
| 1 1
sparser
"Methylation frequency was significantly higher in NAF than adjacent normal tissue for p16 and marginally higher for RAR-β , suggesting that the assessment of p16 and perhaps RAR-β methylation levels in NAF may provide information on whether a breast contains cancer."
19618401
reach
"In our study, we found no association between one-carbon nutrients intake and likelihood of gene promoter methylation for E- cadherin, p16 or RAR-beta 2 in breast tumors or any indication of more than additive interaction for folate and alcohol for E- cadherin promoter methylation."
21916701
PRMT1 affects CDKN2A
| 2
PRMT1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"DNA damage by ultraviolet (UV) light increases the association and methylation of p14 by PRMT1 favoring its nucleolar export to fulfill its proapoptotic role as a tumor suppressor (Repenning et al., 2021) (Figure 3B)."
34619091
PRMT1 methylates CDKN2A on arginine. 1 / 1
| 1
reach
"PRMT1 methylates several arginine residues in the C-terminal nuclear and nucleolar localization sequence (NLS and NoLS) of p14 ARF."
33999432
PRC2_complex affects CDKN2A
| 2
PRC2_complex methylates CDKN2A. 2 / 2
| 2
reach
"This cooperation involves recruitment of PRC2, which trimethylates H3K27 at the E-cadherin and CDKN2A gene promoters 67."
24556840
reach
"These observations suggest that, in the absence of JDP2, H3K27 is methylated by PRC2, and the p16 Ink4a / Arf locus is silenced by PRC1, whereas the increased expression of JDP2 helps to release PRC1 and PRC2 from the p16 Ink4a / Arf locus, thereby reducing H3K27 methylation."
21197464
MYC affects CDKN2A
| 1 1
MYC methylates CDKN2A. 2 / 2
| 1 1
sparser
"In addition, mutations in TP53, RB1, amplifications in MYC and promoter methylation of p16(INK4a) and BRCA2 have been reported in malignant PT and FA tumors ."
26774289
reach
"In addition, mutations in TP53, RB1, amplifications in MYC and promoter methylation of p16 (INK4a) and BRCA2 have been reported in malignant PT and FA tumors [18-20]."
26774289
MTR affects CDKN2A
| 2
MTR methylates CDKN2A. 2 / 2
| 2
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1-3)."
22388100
sparser
"MSP confirmed MS-MLPA methylation of APC (biopsies 1 and 4) and CDKN2A (biopsies 1–3)."
21603083
KRAS affects CDKN2A
| 1 1
KRAS leads to the methylation of CDKN2A. 2 / 2
| 1 1
sparser
"Data from KRAS transformation studies suggest that activated KRAS promotes P16 methylation [ xref ]."
23509688
reach
"Previous report also showed that the mutated K-ras induces p16 hypermethylation, resulting in transcriptional silencing of INK4-ARF in human embryonic stem cells XREF_BIBR."
25029561
GPI affects CDKN2A
| 2
GPI leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"Moreover, Lu et al. discovered that PHI induced histone H3 hyperacetylation and p16 hypomethylation in a concentration dependent manner in myeloma cell line RPMI8226 [XREF_BIBR]."
25891109
reach
"PHI induces p16 DNA hypomethylation."
18577263
E7 affects CDKN2A
| 2
E7 leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"51 The methylation of p16 , which has been proved to be indirectly caused by HPV E7 oncoprotein, 52 was found in CC."
34323415
reach
"It is well known that E7 gene of HPV16 and 18 is involved in Rb inactivation and release of histone deacetylase (HDAC) from E2F-Rb and HDAC complex, enhancing P16INK4A hypermethylation through chromatin remodeling by HDAC XREF_BIBR."
24037287
DNMT3B affects CDKN2A
| 2
Modified DNMT3B leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"These results may support our present data showing that a high prevalence of p16INK4a promoter hypermethylation in lung tumors with HPV infection was more favorably associated with DNMT3b than with DN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16004934
reach
"These results strongly suggested that the involvement of HPV infection in nonsmoking female lung tumorigenesis may be mediated, at least to a certain extent, through the increase of DNMT3b protein expression to cause p16INK4a promoter hypermethylation."
16004934
DNMT3A affects CDKN2A
| 2
Modified DNMT3A leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Surprisingly, DNMT3a overexpression did not increase promoter methylation or expression of CDKN2a and NES, but greatly affected both promoter methylation and expression of the mammary lineage gene KRT19 (representative patient samples in XREF_FIG F, 3G, and XREF_SUPPLEMENTARY C)."
28781076
DNMT3A leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Regulation of DNMT1 and DNMT3A by HBx promoted hypermethylation of p16 (INK4A) promoter region."
20620135
CTNNB1 affects CDKN2A
| 2
CTNNB1 leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"The CTNNB1 subclass show activation of the Wnt/β-catenin pathway, TERT promoter mutations, and CDKN2A and CDH1 promoter hypermethylation (The Cancer Genome Atlas Research Network, 2017; Chiang et al., 2008; Xu et al., 2018)."
35961697
reach
"In this study, we found that simultaneous overexpression of all miRNAs in the miR-23a/27a/24-2 cluster was closely associated with postoperative recurrence, β-catenin upregulation and promoter methylation of p16 and CDH13 in early-stage NSCLC patients."
35071744
AHR affects CDKN2A
| 2
AHR leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"Additionally, in keratinocytes AHR is reported to induce the silencing and hypermethylation of the CDKN2A (p16) tumour suppressor gene and the inhibition of p53 signalling [XREF_BIBR]."
25960784
reach
"In human keratinocytes, AhR was reported to induce silencing and hypermethylation of the CDKN2A (p16) tumor suppressor gene and inhibition of p53 signaling."
27243009
ctd
No evidence text available
18204080
ctd
No evidence text available
20188851
(-)-epigallocatechin 3-gallate leads to the methylation of CDKN2A. 2 / 2
| 2
reach
"In the second series of experiments, we checked whether p16 hypomethylation induced by EGCG or MTX could be reversed by growing the cells in a medium containing leucovorin."
17683969
reach
"EGCG has been shown to cause promoter hypomethylation of p16, RARbeta2, MGMT, hMLH1, WIF-1, GSTP1 and RECK genes across different cancer types and has been reviewed extensively (Singh et al., 2013)."
28612587
reach
"N-methyl-N '-nitro-N-nitrosoguanidine, a well-known gastric carcinogen, has been demonstrated to induce CpG island hypermethylation of p16, and this hypermethylation increased with lesion progression along the multistep gastric carcinogenesis in the rat stomach."
17449942
reach
"P16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N '-nitro-N-nitrosoguanidine."
12547284
Tumour suppressor methylates CDKN2A. 1 / 1
| 1
sparser
"It indicates that the contribution of p16 tumour suppressor methylation in DLBCL development might be of high importance."
29072413
Triclosan affects CDKN2A
1 |
Triclosan methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
26970259
Technetium atom affects CDKN2A
| 1
sparser
"Interestingly, low-dose TCS elevated p16 gene methylation and inhibited p16 expression, which were not observed in high-dose (10μM) group."
26970259
Spn-A affects CDKN2A
| 1
Spn-A methylates CDKN2A. 1 / 1
| 1
sparser
"In the SWS cohort, lower umbilical cord CDKN2A DMR methylation predicted increased adiposity at ages 1, 4 and 6 years but not at birth, suggesting that CDKN2A methylation may be linked to the gain of fat mass postnatally."
28473239
Sodium fluoride affects CDKN2A
1 |
Sodium fluoride methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
30259626
Sodium arsenite affects CDKN2A
1 |
ctd
No evidence text available
11825526
Sodium arsenate affects CDKN2A
1 |
Sodium arsenate methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
11825526
Set1 affects CDKN2A
| 1
Set1 methylates CDKN2A. 1 / 1
| 1
reach
"Moreover, RBP2 depletion led to significantly enhanced H3-K4 trimethylation at the proximal promoter region of p16 ink4a, p21 CIP1, and p27 kip1 genes."
19850045
Selenium atom affects CDKN2A
| 1
Selenium atom leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Furthermore, Se deficiency has been demonstrated to cause global hypomethylation and promoter methylation of the p16 and p53 tumor suppressor genes [XREF_BIBR]."
22022340
Radon atom affects CDKN2A
1 |
Radon atom methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
16902270
Quercetin affects CDKN2A
| 1
Quercetin leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Flavonol quercetin from citrus fruits and buckwheat inhibited the proliferation of colon cancer RKO cells by reversing hypermethylation of the CDKN2A gene promoter DNA [XREF_BIBR, XREF_BIBR]."
28367075
Polycyclic arene affects CDKN2A
| 1
Polycyclic arene leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Consistently, Yang et al. [267] reported that PAH exposure induces CpG site-specific hypermethylation of the p16(INK4α) gene."
34203568
Phorbol 13-acetate 12-myristate leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Examples include the increase of methylation in ribosomal DNA hypermethylated clusters in liver and germ cells of senescent rats [33] and, in humans, CpG island promoter hypermethylation in the tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19500963
PaaK affects CDKN2A
| 1
PaaK methylates CDKN2A. 1 / 1
| 1
sparser
"Forty-one of 98 MM patients (41.8%) as well as four of the five (80%) primary PCL patients showed methylation of the p16 gene, while none of the patients with monoclonal gammopathy of undetermined significance, Waldenström Macroglobulinemia or smoldering multiple myeloma displayed a methylation status."
11920239
P21 waf1 affects CDKN2A
| 1
P21 waf1 methylates CDKN2A. 1 / 1
| 1
reach
"These data would support a role for direct demethylation of these downstream target genes by 5-aza-dc as has previously been shown with the frequent methylation of p16 ink4a and p21 waf1 and cip1 in CRC [XREF_BIBR, XREF_BIBR]."
20196786
Nitrogen dioxide affects CDKN2A
1 |
ctd
No evidence text available
26778509
Nicotinamide affects CDKN2A
1 |
Nicotinamide methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
24792773
Nickel sulfide affects CDKN2A
1 |
Nickel sulfide methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
11984000
Nickel subsulfide methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
21565688
MiR-23a/27a/24-2 cluster miRNAs affects CDKN2A
| 1
MiR-23a/27a/24-2 cluster miRNAs leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Furthermore, we demonstrated that the miR-23a/27a/24-2 cluster miRNAs activated Wnt/β-catenin signaling by targeting their suppressors and stimulated promoter methylation-induced silencing of p16 and CDH13 by affecting DNA methylation-related genes expression."
35071744
MiR-217 affects CDKN2A
| 1
MiR-217 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"These data suggested that miR-217 induced a hypomethylation dependent increase in p16 and pRb expression, likely due to its effect on DNMT1 translation, leading to HSF senescence."
28380423
Methyl affects CDKN2A
| 1
Methyl leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate and methyl deficiency in rats."
12359353
LinE affects CDKN2A
| 1
LinE methylates CDKN2A. 1 / 1
| 1
reach
"Tumor was assessed for DNA methylation (by LINE assays), apoptosis, necrosis, mitoses, Ki67, DNA methyltransferase (DNMT1), CTR1, and p16."
19470736
IspF affects CDKN2A
| 1
IspF methylates CDKN2A. 1 / 1
| 1
reach
"Moreover, MeCPs bind to methylated promoters of MLH1, p16 (INK4a) and master cell cycle regulator and tumour suppressor BRCA1 and recruit repressive complexes that specifically repress target genes XREF_BIBR, XREF_BIBR."
25892967
Inositol affects CDKN2A
| 1
Inositol leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"MSI was associated with BRAF mutation, promoter methylation of hMLH1, APC and p16 (INK4A) and a high MI (total number of methylated genes) (P values : 2.4 x 10 (-2), 2.5 x 10 (-3), 1.8 x 10 (-2), 4.6 x 10 (-2) and 1.0 x 10 (-2), respectively)."
18048385
Hydrogensulfite affects CDKN2A
| 1
reach
"First, we validated differential DNA methylation of the affected downstream CDKN2A region by bisulfite sequencing."
25619363
Hexachlorobenzene methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
26431795
HMLH1 genes affects CDKN2A
| 1
HMLH1 genes methylates CDKN2A. 1 / 1
| 1
reach
"The present study examined aberrant hypermethylation of p16, DAPK, RASSF1A, APC, WIF1, RUNX3, E-cad, MGMT and hMLH1 genes in histologically negative surgical margins of OSCC patients, and their associ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21697000
Glycoprotein affects CDKN2A
| 1
Glycoprotein methylates CDKN2A. 1 / 1
| 1
reach
"EGFR mutation has an inverse correlation with methylation of the p16INK4a gene and SPARC (secreted protein acidic and rich in cysteine), an extracellular Ca2+-binding glycoprotein associated with the regulation of cell adhesion and growth [41]."
| PMC
Glucaric acid affects CDKN2A
1 |
Glucaric acid methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
24792773
Genistein affects CDKN2A
| 1
Genistein leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Genistein suppresses multiple cellular processes such as proliferation and angiogenesis by demethylating tumour suppressor genes p16, MGMT, GSTPi, RARbeta, and hMLH1."
27891254
Folic acid affects CDKN2A
| 1
Folic acid leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"At 14 weeks of age, both maternal and postweaning folic acid supplementation significantly increased DNA methylation of the Ppar-gamma, p53, and p16 genes (p < 0.05) whereas only postweaning FA supplementation significantly increased DNA methylation of the ER-alpha and Apc genes (p < 0.05)."
23463647
Folate affects CDKN2A
| 1
Folate leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate and methyl deficiency in rats."
12359353
Fluoridochlorine affects CDKN2A
| 1
Fluoridochlorine leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"ClF caused hypomethylation of APC, CDKN2A, and PTEN, with a concomitant increase in their transcript levels."
31999420
Fluoride salt affects CDKN2A
1 |
Fluoride salt methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
30259626
Flavonol affects CDKN2A
| 1
Flavonol leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Flavonol quercetin from citrus fruits and buckwheat inhibited the proliferation of colon cancer RKO cells by reversing hypermethylation of the CDKN2A gene promoter DNA [XREF_BIBR, XREF_BIBR]."
28367075
Fenbendazole affects CDKN2A
1 |
Fenbendazole methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
22659510
Dichromic acid affects CDKN2A
1 |
Dichromic acid methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
27005777
Death-associated protein leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"The authors showed that rates of promoter methylation of p16, E-cadherin (CDH-1), and death associated protein kinase (DAPK) were significantly higher in noncancerous gastric mucosa of GC patients than in controls, and this was independent of other parameters."
18783519
Cpg-1 affects CDKN2A
| 1
Cpg-1 methylates CDKN2A. 1 / 1
| 1
sparser
"For every 10% increase in perinatal CDKN2A CpG1 methylation there was a decrease in %fat mass of 0.20 SD (95% CI − 0.33, − 0.06) age 4 years and 0.18 SD (− 0.31, − 0.05) age 6 years, controlling for sex."
28473239
Carbon nanotube affects CDKN2A
1 |
ctd
No evidence text available
29112861
Butyric acid affects CDKN2A
1 |
Butyric acid methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
24792773
Beryllium atom affects CDKN2A
1 |
Beryllium atom methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
11872642
Benzene affects CDKN2A
1 |
Benzene methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
20044985
Asbestos affects CDKN2A
1 |
Asbestos methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
15911247
Arsenite(3-) affects CDKN2A
1 |
Arsenite(3-) methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
21040761
Arsenic molecular entity methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
23073540
Amosite asbestos affects CDKN2A
1 |
ctd
No evidence text available
29112861
Adenoma Promotor affects CDKN2A
| 1
Adenoma Promotor methylates CDKN2A. 1 / 1
| 1
reach
"Pleomorphic adenoma Promotor methylation of p14 ARF was present in 1/42 cases."
12924439
ZNF304 affects CDKN2A
| 1
ZNF304 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Knockdown of ZNF304, KAP1, SETDB1 or DNMT1 also decreased p14 ARF promoter hypermethylation (XREF_FIG)."
24623306
XAF1 affects CDKN2A
| 1
XAF1 methylates CDKN2A. 1 / 1
| 1
reach
"Exposure to DAC for 48 h resulted in a dose dependent reversal of the hypermethylation of the p16 INK4A and XAF1 gene promoters as suggested by an increasing ratio of unmethylated to methylated (U/M) DNA (XREF_FIG)."
19732952
TNF affects CDKN2A
| 1
TNF methylates CDKN2A. 1 / 1
| 1
reach
"Early onset diabetes was associated with IL-6 and TNF-alpha hypomethylation and upregulation of CDKN2A."
32803503
TGM1 affects CDKN2A
| 1
TGM1 methylates CDKN2A. 1 / 1
| 1
reach
"Li et al. identified that lncRNA HOTAIR was upregulated in OS cells and significantly inhibited CDKN2A expression by hypermethylated modification of the CDKN2A promoter."
32143708
TCN1 affects CDKN2A
| 1
TCN1 methylates CDKN2A. 1 / 1
| 1
sparser
"HL-60 and T24 cancer cell lines were treated with azacitidine or decitabine in combination with HC and DNA methylation of LRE1, MAGEA1 and CDKN2A was quantitatively measured by bisulphite-polymerase chain reaction pyrosequencing."
17686055
Soot affects CDKN2A
1 |
Soot methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
11872642
SPARC affects CDKN2A
| 1
SPARC methylates CDKN2A. 1 / 1
| 1
reach
"EGFR mutation has an inverse correlation with methylation of the p16INK4a gene and SPARC (secreted protein acidic and rich in cysteine), an extracellular Ca2+-binding glycoprotein associated with the regulation of cell adhesion and growth [41]."
| PMC
SOCS1 affects CDKN2A
| 1
SOCS1 methylates CDKN2A. 1 / 1
| 1
reach
"Our previous studies have shown that the hypermethylation of p16INK4a [XREF_BIBR] and suppressor of cytokine signaling 1 (SOCS1) [XREF_BIBR] were more likely to happen in male gender patients."
26821013
SGI-110 affects CDKN2A
| 1
SGI-110 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"These authors further demonstrated that SGI-110 produced LINE-1 and p16 (a TSG) hypomethylation in a concentration dependent fashion, associated with robust re-expression of p16 mRNA and protein in both the human bladder carcinoma T24 cell line, as well as the human colon carcinoma HCT 116 cell line."
26190889
SETDB1 affects CDKN2A
| 1
SETDB1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Knockdown of ZNF304, KAP1, SETDB1 or DNMT1 also decreased p14 ARF promoter hypermethylation (XREF_FIG)."
24623306
RUNX3 affects CDKN2A
| 1
RUNX3 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Examples include the increase of methylation in ribosomal DNA hypermethylated clusters in liver and germ cells of senescent rats [33] and, in humans, CpG island promoter hypermethylation in the tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19500963
RASSF1A promoters affects CDKN2A
| 1
RASSF1A promoters methylates CDKN2A. 1 / 1
| 1
reach
"Furthermore, since 5mTHF is involved in the supply of methyl groups to the remethylation cycle in which DNA is a terminal acceptor, FA may alter BC risk through altered epigenetic regulation of tumour suppressor genes as BC can involve hypermethylation of P16INK4a, BRCA1, BRCA2, oestrogen receptor (ER)-alpha, retinoic acid receptor-beta2, APC, and RASSF1A promoters leading to lower transcription and to impaired DNA repair."
27293554
RARbeta gene affects CDKN2A
| 1
RARbeta gene methylates CDKN2A. 1 / 1
| 1
reach
"Soy flavonoids, genistein, biochanin A and daidzein, were shown to reverse DNA hypermethylation of CDKN2A, RARbeta, and MGMT genes in human esophageal squamous KYSE 510 carcinoma cells, as well as RARbeta gene in human prostate cancer LNCaP and PC-3 cells."
28367075
RAF affects CDKN2A
| 1
RAF leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"RAF could stimulate cell proliferation by hypermethylating the promoter of the tumor suppressor gene p16 INK4A in gastric epithelial cells (Wang et al., 2008)."
19450668
QMSP affects CDKN2A
| 1
QMSP methylates CDKN2A. 1 / 1
| 1
reach
"In particular, detection of p16 (INK4a) methylation by QMSP may serve as a highly specific marker of pulmonary squamous cell carcinoma."
15849750
ctd
No evidence text available
26778509
PTEN affects CDKN2A
| 1
PTEN leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"For example, mutation and promoter methylation of p16 and phosphatase and tensin homolog (PTEN) tumor suppressor genes have also been investigated in gastric cancer."
23432957
PAH affects CDKN2A
| 1
PAH leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"PAH exposure induced CpG site specific hypermethylation of p16 (INK4alpha) gene."
22028397
NUP214 affects CDKN2A
| 1
NUP214 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"There is increasing evidence that the hepatitis B X protein can induce methylation of p16 INK4A, supporting the close relationship between HCC and viral liver disease [XREF_BIBR]."
20556199
NPPA affects CDKN2A
| 1
NPPA leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"[Research on the growth inhibition of T47D cell and reversion of p16 hypermethylation by CDP]."
15573756
NFkappaB affects CDKN2A
| 1
NFkappaB leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
24025864
NADPH affects CDKN2A
| 1
NADPH leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Role of NADPH oxidase NOX5-S, NF-kappaB, and DNMT1 in acid induced p16 hypermethylation in Barrett 's cells."
24025864
ctd
No evidence text available
19642983
sparser
"Building on these premises, we systematically investigated the relationship between P16 methylation and the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib using both public datasets and cell models of P16 methylation induced by an artificial P16 -specific methyltransferase (P16-Dnmt) [ xref ]."
31652270
MTX1 affects CDKN2A
| 1
MTX1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"In the second series of experiments, we checked whether p16 hypomethylation induced by EGCG or MTX could be reversed by growing the cells in a medium containing leucovorin."
17683969
MSMB affects CDKN2A
| 1
MSMB methylates CDKN2A. 1 / 1
| 1
sparser
"Detection of p16 and MGMT promoter methylation by MSP."
16533425
MS-UC-FRET affects CDKN2A
| 1
MS-UC-FRET methylates CDKN2A. 1 / 1
| 1
reach
"CDKN2A Methylation in Lung Cancer Tissue by MS-UC-FRET."
27517925
MBD4 affects CDKN2A
| 1
MBD4 methylates CDKN2A. 1 / 1
| 1
reach
"Furthermore, a chromatin immunoprecipitation assay clearly shows that MBD4 binds to hypermethylated promoters of the p16 (INK4a) and hMLH1 genes."
15899845
MAD2L1 affects CDKN2A
| 1
MAD2L1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"The objective of this study was to investigate the role of promoter methylation of p16 (INK4A) and MAD2 genes in gastric marginal-zone B-cell lymphoma (MZBCL)."
19174606
MACROH2A1 affects CDKN2A
| 1
MACROH2A1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"[XREF_BIBR - XREF_BIBR] Interestingly, another study found that macroH2A1 can potentiate silencing, heterochromatin formation, and hypermethylation of the tumor suppressor p16 in CRC, but the work did not distinguish between macroH2A1.1 and macroH2A1.2."
28934364
LOH affects CDKN2A
| 1
LOH methylates CDKN2A. 1 / 1
| 1
reach
"The study shows p16 inactivation in 28.3% (either by LOH or by p16 methylation)."
18243403
LGI1 affects CDKN2A
| 1
LGI1 methylates CDKN2A. 1 / 1
| 1
sparser
"Partial methylation of the p16 gene was also demonstrated in three of eight primary leukemia samples with this translocation, suggesting that the p16 gene inactivation by hypermethylation might play a role in the leukemogenesis and disease progression of ALL with 11q23 translocation."
10360377
LD-MSP affects CDKN2A
| 1
LD-MSP methylates CDKN2A. 1 / 1
| 1
reach
"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
17595762
JNK affects CDKN2A
| 1
JNK leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Inhibition of JNK with SP600125 prevented the PM induced increase in expression of DNMT1 protein (XREF_FIG) and p16 methylation in these cells (XREF_FIG)."
22355787
Infections affects CDKN2A
| 1
Infections leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Persistent HBV infection can cause hypermethylation of p16 , and HBx may play a key role in this process (32)."
36189208
IL6 affects CDKN2A
| 1
IL6 methylates CDKN2A. 1 / 1
| 1
reach
"Early onset diabetes was associated with IL-6 and TNF-alpha hypomethylation and upregulation of CDKN2A."
32803503
HSP90 inhibitors affects CDKN2A
| 1
HSP90 inhibitors leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"HSP90 inhibitors also disrupt the DNMT-1 (DNA methyltransferases)/HSP90 interaction and thus abolish the methylation of the CDKN2A locus [78]."
25837868
HMOX1 affects CDKN2A
| 1
HMOX1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Silencing HO-1 sensitized SKM-1 cells toward AZA, which may be attributed to the influence of HO-1 on AZA induced p16 demethylation."
25585641
HMECs affects CDKN2A
| 1
HMECs methylates CDKN2A. 1 / 1
| 1
reach
"This would agree with the finding that HMECs can rapidly methylate and suppress CDKN2a during culture."
28781076
HC and DNA affects CDKN2A
| 1
HC and DNA methylates CDKN2A. 1 / 1
| 1
sparser
"HL-60 and T24 cancer cell lines were treated with azacitidine or decitabine in combination with HC and DNA methylation of LRE1, MAGEA1 and CDKN2A was quantitatively measured by bisulphite-polymerase chain reaction pyrosequencing."
17686055
H3K27 affects CDKN2A
| 1
H3K27 methylates CDKN2A. 1 / 1
| 1
reach
"Moreover, Ezh2 mediates increased trimethylation of p16INK4a and p19Arf by H3K27, which epigenetically represses Ink4a and Arf production and contributes to proliferation of pancreatic beta cells."
30842756
GKN2 affects CDKN2A
| 1
GKN2 methylates CDKN2A. 1 / 1
| 1
sparser
"A total of 82 NHLs were examined for p16 methylation by Southern blot and PCR analysis."
9067584
GALR1 affects CDKN2A
| 1
Methylated GALR1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"GALR1 methylation is observed in primary HNSCC tumors and correlates with decreased GALR1 expression, as well as increased tumor size, lymph node status, tumor stage, CCND1 expression, p16 methylation, and survival."
22704334
FOXM1 affects CDKN2A
| 1
FOXM1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Hence, whilst FOXM1 can induce promoter hypermethylation of p16 INK4A in " normal " cells, such effect may be perturbed in " cancer " cells."
22461910
FMN1 affects CDKN2A
| 1
FMN1 methylates CDKN2A. 1 / 1
| 1
sparser
"Of 44 colorectal cancer patients, 30 (68%) exhibited abnormal promoter methylation of p16 in their serum DNA by LD-MSP, while 13 (30%) exhibited it by conventional MSP."
17595762
FLT4 affects CDKN2A
| 1
FLT4 methylates CDKN2A. 1 / 1
| 1
sparser
"Forty-one of 98 MM patients (41.8%) as well as four of the five (80%) primary PCL patients showed methylation of the p16 gene, while none of the patients with monoclonal gammopathy of undetermined significance, Waldenström Macroglobulinemia or smoldering multiple myeloma displayed a methylation status."
11920239
EX2 affects CDKN2A
| 1
EX2 methylates CDKN2A. 1 / 1
| 1
sparser
"The only exception was CDKN2A EX2 methylation in Asian subjects (p = 0.11), which may be related to the small sample size but will need to be further explored."
17967182
ESCE affects CDKN2A
| 1
ESCE leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"Interestingly, ESCE induced limited demethylation of RARB and CDKN2A genes, which is consistent with the inability of this extract to re-activate their expression."
21232089
EHMT2 affects CDKN2A
| 1
EHMT2 methylates CDKN2A. 1 / 1
| 1
sparser
"These immortalized (transformed) MSCs showed further enhanced DNA methylation of the p16(INK4a) gene by increased H3K9me."
22873822
EGFR affects CDKN2A
| 1
Mutated EGFR methylates CDKN2A. 1 / 1
| 1
reach
"EGFR mutation has an inverse correlation with methylation of the p16INK4a gene and SPARC (secreted protein acidic and rich in cysteine), an extracellular Ca2+-binding glycoprotein associated with the regulation of cell adhesion and growth [41]."
| PMC
Dioxins affects CDKN2A
1 |
Dioxins methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
15111621
DDT affects CDKN2A
1 |
DDT methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
25410620
CpG affects CDKN2A
| 1
CpG methylates CDKN2A. 1 / 1
| 1
reach
"XREF_BIBR Barrett et al XREF_BIBR demonstrated CpG hypermethylation of CDKN2A in seven progressor samples of a specific genetic clonality; however, no control group was analysed in parallel for this specific marker in this study."
29961009
CpG promoter affects CDKN2A
| 1
CpG promoter methylates CDKN2A. 1 / 1
| 1
reach
"Pyrosequencing provided a sensitive tool for detecting CpG promoter methylation of CDKN2A gene and allowed quantitative assessment of the degree of methylation, because tumor samples often represent a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25542698
Core affects CDKN2A
| 1
Core leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"According to bisulfite sequencing analysis of the p16 promoter from -145 to +136 containing 15 CpG sites, 3.8% and 24.8% of the CpG sequences were methylated in the control cells and Core expressing c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23474497
COBRA affects CDKN2A
| 1
COBRA methylates CDKN2A. 1 / 1
| 1
sparser
"For an independent confirmation of these results, we again deaminated genomic DNA and analysed p16 methylation by COBRA ( xref )."
15860770
CDKN1B affects CDKN2A
| 1
CDKN1B methylates CDKN2A. 1 / 1
| 1
reach
"We observed that hypermethylation of the p15INK4b, p16INK4a and p21cip1 promoters, but not the p27kip1 promoter, was partly correlated with markedly decreased mRNA expression."
22293850
CDKN1A affects CDKN2A
| 1
CDKN1A methylates CDKN2A. 1 / 1
| 1
reach
"These data would support a role for direct demethylation of these downstream target genes by 5-aza-dc as has previously been shown with the frequent methylation of p16 ink4a and p21 waf1 and cip1 in CRC [XREF_BIBR, XREF_BIBR]."
20196786
CDH1 affects CDKN2A
| 1
CDH1 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"The authors showed that rates of promoter methylation of p16, E-cadherin (CDH-1), and death associated protein kinase (DAPK) were significantly higher in noncancerous gastric mucosa of GC patients than in controls, and this was independent of other parameters."
18783519
CBX7 affects CDKN2A
| 1
CBX7 leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"In consideration of above observation that CBX7 is downregulated in primary gastric carcinomas with p16 methylation and CBX7 knockdown does not induce demethylation of p16 in PC3 cells, it is likely that CBX7 upregulation may be sufficient for induction or maintenance of H3K9me3, but not for the establishment of DNA methylation within the p16 locus."
21060834
CASP8 affects CDKN2A
| 1
CASP8 methylates CDKN2A. 1 / 1
| 1
reach
"Promoter methylation status : CASP8 : in 36/40 tumors methylated; TIMP3 : 1/38 methylated; MGMT 0/44 methylated; CDKN2A : 1/46 methylated; E-cadherin 3/36 methylated; no association between methylation status and clinical outcome."
16688669
BRAF affects CDKN2A
| 1
BRAF-V600E leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"V600E Braf induces CpG methylation of p16 INK4a."
20941790
ctd
No evidence text available
30871143
APBA1 affects CDKN2A
| 1
APBA1 methylates CDKN2A. 1 / 1
| 1
reach
"Interestingly, the frequencies of methylation of CDH1, CDKN2A (P trend = 0.04), and MINT1 (P trend = 0.02) in non-IM mucosa increased in the GC group (Fig. 2)."
30254207
ANRIL affects CDKN2A
| 1
ANRIL methylates CDKN2A. 1 / 1
| 1
reach
"ANRIL binds with PRC1 at the RNA binding domains of CBX7 and methylates the CDKN2A promoter region at H3K27, which inhibits CDKN2A gene expression."
27428416
7,12-dimethyltetraphene methylates CDKN2A. 1 / 1
1 |
ctd
No evidence text available
24792773
reach
"These results however are in good agreement with previous reports showing the hypermethylation of tumor suppressor p16 by PMs from urban areas, which could lead to cancer development 39 and the induction of lung carcinoma by Mo inhalation exposure in mice."
25347054
5-Aza-2’-deoxycytidine affects CDKN2A
| 1
5-Aza-2’-deoxycytidine leads to the methylation of CDKN2A. 1 / 1
| 1
reach
"5-Aza-2’-deoxycytidine treatment attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats by decreasing TGF-β1 expression and increasing p16 expression by reversing the hypermethylation of p16 [86]."
35673969