IndraLab

Statements

CXXC1 methylates CDKN2A. 65 / 65
| 65
sparser
"Southern blots showed methylation of p15 at one CpG site in an Eag I site, and no methylation of p16 at one CpG site in a Sac II site."
11532526
sparser
"In genome analysis, the CpG methylation of p16 (cyclin-dependent kinase inhibitor 2A) is observed in all ameloblastic carcinoma samples, but only one ameloblastoma specimen exhibits the mutation."
24799899
sparser
"Pyrosequencing provided a sensitive tool for detecting CpG promoter methylation of CDKN2A gene and allowed quantitative assessment of the degree of methylation, because tumor samples often represent[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25542698
sparser
"Matrix-assisted laser desorption ionization-time of flight mass spectrometry was applied to detect methylation of CpG sites in the promoter region of the P16 gene; polymerase chain reaction was performed to assess HPV16 infection in the 2 groups."
25222242
sparser
"In addition to mutation and homozygous deletions, frequent 5′-CpG island methylation of CDKN2A gene resulting in transcriptional silencing of this gene is noted as an important event in the development of EC."
26283007
sparser
"Thus, there were no significant differences in the methylation of all the 7 CpG sites of p16 gene."
29019900
sparser
"Accordingly, the investigators observed the CpG methylation of p16 in all collected ameloblastic carcinoma specimens."
22705216
sparser
"The overall genome CpG methylation and promoter methylation of PTEN and CDKN2A were unaffected in the lesions."
25229773
sparser
"The low frequency of p16 Ink4a CpG methylation found could therefore be explained by the occurrence of methylation po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11163109
sparser
"Of 12 HCCs with lower p16 mRNA expression level, 11 cases showed p16 promoter CpG islands methylation (91.6%)."
15112341
sparser
"Specifically, the CpG island methylation in p16 and p21 were examined by MSP in early passage hBMDS cells as well as the clonal line from hBMDS cells."
22833839
sparser
"A CpG island methylation of p16 was identified by polymerase chain reaction."
22705216
sparser
"The above authors also analyzed six PCNSL for p16 INK4A CpG island methylation and detected aberrant patterns in three, in which p16 INK4A mRNA or pro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12660028
sparser
"Expression of p16, CDKN2A HD and 5' CDKN2A CpG island methylation was studied in 25 oligodendrogliomas by immunohistochemistry and PCR amplification."
11058870
sparser
"Here we have developed methylation-specific polymerase chain reaction (MSPCR) methods to detect methylation of CpG sites in p14(ARF) in CRC cell lines and primary CRC tumors, and correlated p14(ARF) mRNA expression with methylation in CRC cell lines using competitive quantitative reverse transcription-polymerase chain reaction methods."
11062168
sparser
"Results were supported by modulation of global DNA methylation and the modulation of promoter CpG methylation of p16, MLH1, and COX-2 genes."
21154115
sparser
"Similarly, the mean age of 4 patients who had PanINs showing p16 CpG island methylation was also older (70.8 years) than that of the other 25 patients (62.0 years)."
12000709
sparser
"We used two different technical approaches to detect changes in CpG methylation in the promoter region of the CDKN2A gene; methylation-specific PCR (MSP) analysis of bisulfite-converted DNA and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)."
21479383
sparser
"CpG methylation of the p16INK4a, RASSF1A, E cadherin, and GSTP1 genes was correlated to the reduction of mRNA levels in the cell lines, and mRNA expression of these 4 genes were indeed restored by low concentrations (2-6 micromol/L) of As2O3 through demethylation, as well as 1 micromol/L of 5-aza-2'-deoxycytidine."
16613325
sparser
"Methylation-specific PCR (MSP) was employed to detect promotor CpG island methylation of the DAPK, p16, and MGMT genes in 85 surgical tumor tissue samples and 40 pretreatment plasma samples from cervical cancers."
15099958
sparser
"Since it has been reported that BCC retain wild-type p16(INK4A) and here BCC with CpG-methylation of 14-3-3sigma did not show CpG-methylation of p16(INK4A) (0/17), silencing of 14-3-3sigma may contribute to evasion of senescence in BCC."
12934112
sparser
"In genome analysis, the CpG methylation of p16 (cyclin-dependent kinase inhibitor 2A) is observed in all ameloblastic carcinoma samples, but only one ameloblastoma specimen exhibits the mutation."
23837011
sparser
"CpG island methylation of p16 also correlated with patient age and metastatic status [ xref ]."
27418145
sparser
"P16 promoter CpG island methylation likely made p16 expressing silence thus contributed to the tumorigenesis of lung adenocarcinoma."
26629075
sparser
"In skeletal muscle, CpG sites in CDKN2A , DUSP9 , HNF4A , HHEX , KCNQ1 , KLF11 , PPARGC1A and SLC30A8 were differentially methylated."
23251491
sparser
"In this analysis, CpG methylation of genes (yes/no status) APC, GSTP1, MGMT , and P16 was not associated with any risk factors (data not shown)."
19861513
sparser
"Note that p16INK4a CpG island methylation is associated with its transcriptional silencing [ xref ]."
29176034
sparser
"CpG methylation of the p16 gene was observed in all ameloblastic carcinoma samples."
22705216
sparser
"Sex, BO segment length and histological diagnosis were combined with p16, HPP1 and RUNX3 CpG methylation status as well as a methylation index with a score of 0–3 was considered."
29961009
sparser
"On the other hand, the human p14ARF has a 5'CpG island in its promoter region, and some cell lines also have 5'CpG island methylation in the regulatory region of the p14ARF gene."
19101490
sparser
"Our study reports that high CpG island methylation of p16 gene and loss of p16 protein expression associate with the development and progression of ToF, which may have significant therapeutic applications for ToF."
27994181
sparser
"This observation suggests that the 5′ CpG island methylation of the p16 gene is another important mechanism by which p16 expression is regulated in leukemia, especially in B-ALL and AML."
10634644
sparser
"Results from the GMDR model showed that interaction existed among the high exposure of 1-hydroxy pyrene and the CpG island methylation of p16, FHIT in CINⅠ and CINⅡ/Ⅲ group."
28847065
sparser
"There was no significant correlation between P16 CpG methylation and HPV16 infection in Uyghur patients with CSCC."
25222242
sparser
"Many studies have investigated the potential role of expression genes for prognostic use, and unsurprisingly most of them are similar to those with a high potential for diagnostic use; in example, promoter CpG methylation of HLTF and CDKN2A is used with prognostic and diagnostic functions in tumours [ xref , xref ]."
27927793
sparser
"We have tested whether CpG methylation of both CDKN2A and TP73 occurs in 45 individuals with multiple myeloma (24 male and 21 female, mean age 66.4 years) and in 4 patients (2 male and 2 female, mean age 61.7 years) with Waldenström's macroglobulinemia."
19423161
sparser
"The overall survival was poorer in the patients with CpG island methylation of APC, p16, and TIMP3 than in the patients without methylation (Kaplan-Meier log-rank test, P = 0.0128, 0.0447, and 0.0137, respectively)."
12213730
sparser
"Twenty-seven percent (11 of 40) of NHLs at diagnosis and 31% (4 of 13) at relapse had p16 CpG island methylation."
12213729
sparser
"An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC , and BRAF genes, methylation at CpG sites of MLH1 and p16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series."
18767147
sparser
"Promotor CpG island methylation of DAPK, p16, and MGMT was detectable, respectively, in 60%, 28.2%, and 18.8% of cases of cervical tumor DNA; and in 40%, 10%, and 7.5% of cases of patients' plasma DNA."
15099958
sparser
"Here we have developed methylation-specific polymerase chain reaction (MSPCR) methods to detect methylation of CpG sites in p14(ARF) in CRC cell lines and primary CRC tumors, and correlated p14(ARF) mRNA expression with methylation in CRC cell lines using competitive quantitative reverse transcription-polymerase chain reaction methods."
11062168
sparser
"Although CpG methylation of p16 was observed in all ameloblastic carcinoma samples, only 1 ameloblastoma specimen exhibited the mutation."
22705216
sparser
"Smoking is likely to promote p16 CpG island methylation or by its effect of the activity and metabolism of DNA methyltransferase 1 (DNMT) on CpG island methylation status."
26629075
sparser
"These results suggest that methylation is a frequent event in cholangiocarcinomas and contributes to the cholangiocarcinogenesis, and that CpG island methylation of APC, p16, or TIMP-3 may serve as a potential prognostic biomarker of the cholangiocarcinomas."
12213730
sparser
"We have not observed CpG island methylation of the ppENK and p16 gene in normal pancreatic tissues, but it is possible that such aberrant methylation quickly results in clonal expansion and is thu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12000709
sparser
"Conclusion: Under the high exposure of 1-hydroxy pyrene and the CpG island methylation of p16, FHIT appeared to have increased the risk of cervical intraepithelial neoplasia and causing synergistic effect in cervical intraepithelial neoplasia."
28847065
sparser
"Methods: CDKN2A promoter CpG methylation was measured in peripheral blood from 812 adolescents aged 17 years (Western Australian Pregnancy Cohort Study)."
31552104
sparser
"11 All four of the invasive carcinomas showing p16 CpG island methylation also showed ppENK gene methylation."
12000709
sparser
"Because 5'CpG islands methylation of p16 and p15 genes might be an early event in HCC xref - xref , and because the gene expression due to extensive CpG island methylation had accepted as the main cause of inactivation of the p16 gene xref , the risk of p16 methylation directly response to the pathogenesis of HCC."
29896276
sparser
"The main genetic alterations are deletions (bi- or monoallelic) or 5' CpG island methylation of p15 and p16; very few cases or cell lines had p18 or p19 deletions or hypermethylation."
9639410
sparser
"Significant correlation between folates and methylation at specific CpG sites of p16 and MLH1 were different from those linked to arsenic exposure; in this study, we found correlations with methylation of p16 sites 3 and 5 and MLH1 site 4, compared with sites 1 both in p16 and MLH1 associated with arsenic exposure."
28748002
sparser
"In human PGL samples, promoter CpG methylation of the p16 INK4A gene alone as well as promoter methylation of at least 3 of the following genes RASSF1A , NORE1A ,p16 INK4A , RARB , DCR2 , CDH1 and APC (i.e. CpG island methylator phenotype (CIMP)) but notp14 ARF has been shown to correlate with aggressive tumor behavior xref , xref ."
21167381
sparser
"Vit B12 and folates correlated with DNA methylation in specific CpG sites of p16 , MGMT , and MLH1 genes."
28748002
sparser
"EBNA3C inactivation did not alter p16(INK4A) promoter CpG methylation, but reduced already low H3K27me3, relative to resting B cells, and increased H3K4me3 and H3-acetylation, linking EBNA3C inactivation to histone modifications associated with increased transcription."
21245331
sparser
"DNA methylation of TP53 and p16 at CpG sites was quantified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) of the MassArray system (Sequenom EpiTYPER [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27005777
sparser
"Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carci­nogens."
17971904
sparser
"In this regard, a nucleosome boundary is likely to be present around the target site for sgRNA_mid2 in CpG-methylated p16INK4a in the human gastric adenocarcinoma cell line AGS xref ."
27465215
sparser
"The aim of the current study was to investigate p16 CpG island methylation and establish any correlation with mRNA expression in a north Indian population."
27644676
sparser
"CIMP+ tumors are identified based on promoter CpG island methylation of CDKN2A and MLH1 genes, and these tumors tend to have a unique molecular and clinicopathological profile compared to CIMP lesions."
29614786
sparser
"CpG island methylation of p16 gene, which has been observed in prostate cell lines, appears rare in prostate cancer tissues ( xref ; xref ; xref ; xref ; xref ; xref )."
19936097
sparser
"Leda et al. found the level of p16 CpG methylation to increase in highly lead-exposed individuals and that this might indicate that gene-specific hypermethylation could be involved in the mechanism of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21396434
sparser
"The difference of the methylating rates in both smokers and non-smokers was significant to suggest the closely association of CpG island methylation of p16 with smoking."
26629075
sparser
"DNA damage of PBMCs and the p14(ARK), p15(INK4b) and p16(INK4a) gene CpG island methylation in the promoter region were detected by comet assay and methylation-specific polymerase chain reaction techniques, respectively."
24837742
sparser
"Conversely, there were no significant changes in CpG methylation in the p16 and p21 genes (data not shown)."
29466247
sparser
"5'CpG islands methylation of p16 and p15 genes might be an early event in hepatocarcinogenesis."
15112341