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CDKN2A methylates CDKN2A. 56 / 56
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"The absence of p14 protein in cell lines with p14 methylation and re-expression of transcriptionally silenced p14 after treatment with 5-aza-2′-deoxycytidine confirms that the signal is attributable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CDKN2A methylation and loss of CDKN2A (p16) in colorectal cancer."
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"The findings of the present study also showed that TRAP exposure could increase p16 CDKN2A and APC gene promoter methylation."
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"Every 1 μg/m 3 increase of PM 10 resulted in 0.01% and 0.02% decrease of LINE - 1 and iNOS methylation, and 0.029% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% decrease of iNOS promoter methylation in lung tissue DNA, and 0.18 and 0.19 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
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"However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p16) expression independent of CIMP status remains uncertain."
20473920
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"We therefore evaluated the prognostic role of CDKN2A promoter methylation and loss of CDKN2A (p16) independent of CIMP status, utilizing the database of a large number (N=902) of clinically and molecularly-annotated colorectal cancers."
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"Methylation of p14(ARF) was often accompanied by p16(INK4a) methylation; however, 50% of p14(ARF) methylated tumors contained unmethylated p16(INK4a)."
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"To validate prediction data on the p16 nucleosome occupancy in the human genome (XREF_FIG) XREF_BIBR, we characterized nucleosome position within p16 CpG island in the p16 methylated human GC cell line AGS and the p16 unmethylated cell line MGC803 (detected by 392 bp DHPLC) using the mono-nucleosomal DNA as the template."
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"Nonetheless, it is unlikely that chemotherapy use substantially differed according to CDKN2A methylation or loss of CDKN2A (p16) in tumor, since such data were not available for treatment decision making."
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"Sex could interact with PM 2.5 in affecting blood APC promoter methylation, interact with PM 10 in affecting lung tissue LINE - 1 methylation, and interact with PM 2.5 in affecting lung tissue p16 CDKN2A promoter methylation ( xref )."
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"These observations suggest that, in the absence of JDP2, H3K27 is methylated by PRC2, and the p16 Ink4a / Arf locus is silenced by PRC1, whereas the increased expression of JDP2 helps to release PRC1 and PRC2 from the p16 Ink4a / Arf locus, thereby reducing H3K27 methylation."
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"The results showed that after age, sex, season, body weight, lung weight, and temperature were adjusted, exposure in the tunnel for 1 more day resulted in significant decrease of LINE - 1 (by 0.61% in blood DNA and 0.32% in lung tissue DNA) and iNOS promoter (by 0.84% in blood DNA and 0.69% in lung tissue DNA) methylation, and significant increase of p16 CDKN2A promoter methylation in lung tissue DNA (by 0.25%) ( xref )."
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"Further studies are needed to elucidate the exact mechanisms by which CDKN2A methylation or loss of CDKN2A (p16) leads to colorectal cancer development."
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"In contrast to the associations in blood, the findings in lung tissues showed that H3K9ac was negatively associated with both LINE - 1 and iNOS methylation, and positively associated with APC and p16 CDKN2A promoter methylation."
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"The absence of p14 protein in cell lines with p14 methylation and re-expression of transcriptionally silenced p14 after treatment with 5-aza-2′-deoxycytidine confirms that the signal is attributable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11839577
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"Expression of p16 protein and promoter methylation of the p16 gene between the benign and the malignant components was compared statistically."
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"In conclusion, in our large database of colorectal cancers, CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis."
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"Notably, P16 -specific methylation by P16-Dnmt directly increased the sensitivity of lung cancer cells to palbociclib in vitro and in vivo ."
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"The absence of p14 protein in cell lines with p14 methylation and re-expression of transcriptionally silenced p14 after treatment with 5-aza-2′-deoxycytidine confirms that the signal is attributable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Results Methylation status of p14ARF and p16INK4a gene HNSCC Promotor methylation of p14 ARF was present in 8 out of 50 cases (16%)."
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"Results Methylation status of p14ARF and p16INK4a gene HNSCC Promotor methylation of p14 ARF was present in 8 out of 50 cases (16%) (Table 1)."
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"Then, future studies are needed to evaluate the interaction of HPV16 infection and p16INK4a promoter methylation on expression p16 in HNSCC."
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"Nonetheless, it is unlikely that chemotherapy use substantially differed according to CDKN2A methylation or loss of CDKN2A (p16) in tumor, since such data were not available for treatment decision making."
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"In our current study, we have found that CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis of colorectal cancer patients."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR Our current study is the only one study that assessed the prognostic significance of CDKN2A methylation and loss of CDKN2A (p16) independent of these potential confounders."
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"Overexpression of p53 and hypermethylation of CDKN2A (P16INK-4a) have been reported in OSD ."
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"Methylation of p14(ARF) was often accompanied by p16(INK4a) methylation; however, 50% of p14(ARF) methylated tumors contained unmethylated p16(INK4a)."
11062168
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"We conducted this study to examine prognostic effect of CDKN2A (p16) promoter methylation and loss of CDKN2A (p16) independent of the CpG island methylator phenotype (CIMP), utilizing 902 clinically and molecularly-annotated colorectal cancers."
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"We continued examining the p16 INK4A data in controls and in the special histological subtypes of thyroid tu- mors: p16 INK4A promotor methylation P16 INK4A promotor methylation was found in only 2 of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p16) expression independent of CIMP status remains uncertain."
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"The findings of the present study showed that p16 CDKN2A gene promoter methylation did not change significantly after 4 h exposure."
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"These findings suggest that rapid TRAP exposure may not be sufficient to increase p16 CDKN2A gene promoter methylation, which could be associated with the powerful clearance ability of the respiratory system."
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"To explore possible epigenetic mechanisms of fiber-induced carcinogenesis, we examined gDNA from animals with advanced LNT-induced inflammatory lesions and inflammatory lesions and/or tumors from animals with LNT-induced mesothelioma (#610 and #461), as well as inflammatory lesions and/or tumors from animals with LFA-induced mesothelioma (#398), for p16 Ink4a or p19 Arf methylation status."
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"In our current study, we have found that CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis of colorectal cancer patients."
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"Nonetheless, it is unlikely that chemotherapy use substantially differed according to CDKN2A methylation or loss of CDKN2A (p16) in tumor, since such data were not available for treatment decision making."
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"Prognostic significance of CDKN2A promoter methylation or loss of CDKN2A (p16) in colorectal cancer xref - xref or normal-appearing mucosa adjacent to colorectal cancer xref has been studied ( xref )."
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"In consistent with this hypothesis, we found that P16 methylation by P16-Dnmt directly increased the paclitaxel IC50 value of BGC823 cells, whereas reactivation of P16 demethylation by P16-TET directly decreased the IC50 in H1299 cells."
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"Further studies are needed to elucidate the exact mechanisms by which CDKN2A methylation or loss of CDKN2A (p16) leads to colorectal cancer development."
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"Dulaimi et al. reported the hypermethylation of APC, RASSF1A or CDKN2A (p14ARF) in urine ctDNA from 39 out of 45 BC patients (87% sensitivity and 100% specificity), even detecting 16 cases that showed a negative result in cytology assays [111]."
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"The absence of p14 protein in cell lines with p14 methylation and re-expression of transcriptionally silenced p14 after treatment with 5-aza-2′-deoxycytidine confirms that the signal is attributable t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11839577
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"Both p16INK4A methylation and lack of p16 immunoreactivity were significantly related to larger tumor size and increased grade."
21415872
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"Season could interact with PM 2.5 , PM 10 , and NO 2 in affecting blood LINE-1 methylation, interact with PM 10 and NO 2 in affecting blood p16 CDKN2A promoter methylation, interact with PM 2.5 in affecting lung tissue LINE - 1 methylation, and interact with PM 10 in affecting lung tissue p16 CDKN2A promoter methylation."
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"CDKN2A promoter methylation and loss of CDKN2A (p16) were associated with shorter overall survival in univariate Cox regression analysis [hazard ratio (HR), 1.36; 95% CI, 1.10-1.66; p=0.0036 for CDKN2A methylation; HR, 1.30; 95% CI, 1.03-1.63; p=0.026 for CDKN2A (p16) loss] but not in multivariate analysis that adjusted for clinical and tumor variables including CIMP, MSI, and LINE-1 methylation."
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"Further studies are needed to elucidate the exact mechanisms by which CDKN2A methylation or loss of CDKN2A (p16) leads to colorectal cancer development."
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"In contrast, P16 -specific methylation by P16-Dnmt significantly increased paclitaxel resistance of lung cancer HCC827 cells and gastric cancer BGC823 cells (IC50 values increased from 18.2 to 24.0 ng/ml and 0.18 to 0.81 µg/ml, respectively; P =0.049 and <0.001, respectively)."
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"However, 7 d exposure at the tunnel but not crossroad significantly increased p16 CDKN2A gene promoter methylation."
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"Dominguez et al. [11] also reported a significant correlation between methylation of both p16 INK4a and p14 ARF genes and poor prognostic clinicopathologic parameters in breast, colon, and bladder car[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"p53 mutations and p14 alternative reading frame methylation status were also assessed."
11208819
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"After sex, season, SO 2 level, temperature, and age were adjusted, the results showed that every 1 μg/m 3 increase of PM 2.5 resulted in 0.04% increase of p16 CDKN2A promoter methylation in blood DNA, 0.02% and 0.06% decrease of LINE - 1 and iNOS methylation in lung tissue DNA, 0.01% and 0.01% increase of APC and p16 CDKN2A promoter methylation in lung tissue DNA, and 0.64 and 0.66 ng/mg protein increase of H3K9ac from PBMC and lung tissue histone, respectively."
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"In conclusion, in our large database of colorectal cancers, CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis."
20473920
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"There are advantages in utilizing the database of the two prospective cohort studies, the Nurses' Health Study and the Health Professionals Follow-up Study to examine prognostic significance of CDKN2A methylation or loss of CDKN2A (p16)."
20473920
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"In our current study, we have found that CDKN2A methylation or loss of CDKN2A (p16) is not independently associated with prognosis of colorectal cancer patients."
20473920
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"Every 1 μg/m 3 increase of NO 2 resulted in 0.08% and 0.10% increase of iNOS methylation in DNA from blood and lung tissues, and 0.09% decrease of p16 CDKN2A promoter methylation in DNA from blood, respectively ( xref )."
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"CDKN2A methylation and loss of CDKN2A (p16) in colorectal cancer."
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"p53 mutations and p14 alternative reading frame methylation status were also assessed."
11208819
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"Multivariate analysis to assess relations with CDKN2A methylation or loss of CDKN2A (p16)."
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