IndraLab

Statements

CXXC1 methylates CDKN2A. 7 / 7
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"To this end, we mixed gDNA of HCT116 (one copy of each CpG-methylated and unmethylated CDKN2A (p16) ) and 293T (two copies of unmethylated CDKN2A (p16) ), so that the CpG-methylated CDKN2A (p16) accounted for 5–0.05% of total CDKN2A (p16) , and then subjected them to bisulfite treatment."
32698480
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"CpG island methylation in p16 Ink4a was observed in a subset of BRAF V637E -induced serrated adenomas with dysplasia and carcinomas [ xref ]."
31735291
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"In ameloblastic carcinoma, aberrant CpG island methylation of p16 was identified however there were no mutational alterations in p53 exons 5–8 [ xref ]."
35048074
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"ORNi-PCR with ORN_p16_U and ORN_p16_M strongly suppressed the amplification of the target CDKN2A (p16) sequence from bisulfite-treated unmethylated and CpG-methylated human gDNA, respectively, as shown in xref A. Amplification from bisulfite-treated HCT116 gDNA was moderately suppressed by each ORN, probably due to the hemi-allelic CpG methylation of CDKN2A (p16) ."
32698480
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"Effect of VPA/hydralazine on CpG island methylation of CDKN2A in mammary tumors."
31889127
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"Conclusions: Our results indicate that carrying the minor allele of the MAFK polymorphisms, particularly when they are located in the 3'-UTR, has a high risk for the severity of gastric mucosal atrophy; furthermore, CDKN2A CpG methylation may develop in subjects with homozygous minor allele of these polymorphisms."
33877894
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"In HCT116 cells, the CDKN2A (p16) genes are CpG-methylated in one allele but not in the other allele (i.e., there exist one copy of CpG-methylated and another copy of unmethylated CDKN2A (p16) gene) [ xref ]."
32698480