IndraLab

Statements


E7 leads to the methylation of CDKN2A. 2 / 2
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"51 The methylation of p16 , which has been proved to be indirectly caused by HPV E7 oncoprotein, 52 was found in CC."

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"It is well known that E7 gene of HPV16 and 18 is involved in Rb inactivation and release of histone deacetylase (HDAC) from E2F-Rb and HDAC complex, enhancing P16INK4A hypermethylation through chromatin remodeling by HDAC XREF_BIBR."