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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EZH2 leads to the methylation of CDKN2A. 3 / 3

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"The knockdown of EZH2 in cultured CC cells decreased p16 INK4a methylation and decreased binding of EZH2 to the p16 INK4a gene promoter."

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"Ezh2 knockdown with shRNA eliminated H3K27me mediated DNA methylation of the p16 (INK4a) gene in presenescent MSCs, but had no effect on H3K9me enhanced DNA hypermethylation in the cells after senescence escape."

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"The authors concluded from their study that EZH2-dependent histone methylation and repression of the Ink4a / Arf locus are required for β-cell expansion [ xref , xref ]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...