IndraLab

Statements

GNAS methylates CDKN2A. 6 / 6
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"Because the INK4 gene is frequently inactivated by de novo methylation, we investigated the frequency of INK4a exon 1alpha methylation in a subset of 120 primary breast cancers using methylation-specific PCR; 24 of these were methylated."
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"Out of 50 lung cancer tissues, 16 were positive for the p16 gene exon 1 methylation (32.0%), and 14 for the p16 gene exon 2 deletion (28.0%)."
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"Nguyen and colleagues 31 reported a high frequency of p16 INK4a exon 2 methy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in 54 cases of normal lung tissues, only 2 showed the p16 gene exon 1 methylation(3.7%), and none showed the p16 gene exon 2 deletion."
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"The functional consequences of CDKN2A exon 2 DNA methylation in tumor samples merits further investigation."
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"Since Herman et al xref first reported inactivation of CDKN2A by DNA methylation in prostate cancer, other researchers have investigated the role of hypermethylated CDKN2A in the carcinogenesis and progression of prostate cancer. xref , xref – xref , xref – xref Although there was no significant association between CDKN2A low expression and increased CDKN2A exon 2 methylation, the exon 2 methylation may be a potential biomarker for prostate tumor. xref These results were confirmed by other investigators."
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