IndraLab

Statements


Histone methylates CDKN2A. 3 / 3
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sparser
"Histone methylation in APC, INK4a, and MLH has been frequently observed in sporadic colon cancer: APC and INK4a are tumor suppressor genes and MLH controls DNA stability ( xref – xref )."

reach
"Moreover, hypermethylation mediated silencing of p14 (ARF) expression [XREF_BIBR] and decreased Fas expression by histone modifications (methylation and acetylation) [XREF_BIBR] have also been proposed as a mechanism of IPF lung fibroblast resistance to apoptosis."

reach
"These studies for the first time link Twist-1 to histone methylation of the Ink4A and Arf locus by controlling the expression of histone methyltransferases as well as the expression of other bHLH factors."