IndraLab

Statements

ARF methylates CDKN2A. 28 / 28
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"Association ofp16 INK4A andp14 ARF methylation and tumor grade in cancer."
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"Although some studies involvingp16 INK4A andp14 ARF promoter methylation included patients with RCC, the studies published in this field have had small sample sizes."
28969078
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"More studies with sufficient data are necessary to further evaluate the prognostic value ofp16 INK4A andp14 ARF promoter methylation in RCC."
28969078
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"Prognostic value ofp16 INK4A andp14 ARF gene promoter methylation in RCC."
28969078
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"Association ofp16 INK4A andp14 ARF methylation and lymph node status in cancer."
28969078
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"Analysis of the pooled OR showed thatp16 INK4A andp14 ARF promoter methylation were significantly higher in patients with RCC than in control subjects, suggesting thatp16 INK4A andp14 ARF inactivation via promoter methylation may play an important role in the tumorigenesis of RCC."
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"The pooled OR from seven studies and from three studies suggested thatp16 INK4A andp14 ARF promoter methylation was not significantly correlated with tumor grade in RCC (OR = 1.20, 95% CI = 0.58-2.45, P = 0.625; OR = 2.13, 95% CI = 0.96-4.75, P = 0.063, respectively) (Table xref )."
28969078
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"In addition, our findings showed thatp16 INK4A andp14 ARF promoter methylation were not significantly associated with tumor grade, tumor stage, and lymph node status."
28969078
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"Of these studies, which involvedp16 INK4A andp14 ARF gene promoter methylation, nine studies evaluated the association betweenp16 INK4A promoter methylation and RCC risk, five studies assessed the correlation betweenp14 ARF promoter methylation and RCC risk, ten studies evaluated the relation betweenp16 INK4A promoter methylation and clinicopathological features, and four studies evaluated the relation betweenp14 ARF promoter methylation and clinicopathological features."
28969078
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"Although numerous studies have been conducted to evaluate the role ofp16 INK4A andp14 ARF promoter methylation in RCC, the results are still inconsistent and controversial."
28969078
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"In conclusion, our study showed that RCC had a higherp16 INK4A andp14 ARF gene promoter methylation than did nonmalignant control patients."
28969078
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"The pooled OR from five studies and two studies showed thatp16 INK4A andp14 ARF promoter methylation was not significantly associated with lymph node status in RCC (OR = 0.69, 95% CI = 0.18-2.69, P = 0.595; OR = 0.35, 95% CI = 0.04-2.83, P = 0.326, respectively) (Table xref )."
28969078
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"We further determined whetherp16 INK4A andp14 ARF promoter methylation were correlated with clinicopathological features."
28969078
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"Association betweenp16 INK4A andp14 ARF promoter methylation and RCC risk."
28969078
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"Therefore, in this study, we performed a systematic meta-analysis to further evaluate the clinical significance ofp16 INK4A andp14 ARF promoter methylation in RCC."
28969078
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"Association ofp16 INK4A andp14 ARF methylation and tumor stage in cancer."
28969078
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"In addition, whetherp16 INK4A andp14 ARF promoter methylation is associated with clinical characteristics of RCC remains to be determined."
28969078
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"The pooled OR from four studies and from one study showed thatp16 INK4A andp14 ARF promoter methylation was not significantly associated with tumor stage in RCC (OR = 1.00, 95% CI = 0.42-2.36, P = 0.999; OR = 1.03, 95% CI = 0.18-5.98, P = 0.97, respectively) (Table xref )."
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"Further large-scale studies with well-designed research are necessary to validate the role ofp16 INK4A andp14 ARF promoter methylation in the prognosis and clinical effects of RCC patients in the future."
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"However, the clinical effects ofp16 INK4A andp14 ARF promoter methylation on renal cell carcinoma (RCC) remain to be clarified."
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"Association ofp16 INK4A andp14 ARF methylation and the pathological T category of primary tumor (pT) in cancer."
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"Association ofp16 INK4A andp14 ARF methylation and gender in cancer."
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"Additional studies with sufficient data are essential to further evaluate the clinical features and prognostic effect ofp16 INK4A andp14 ARF promoter methylation in RCC."
28969078
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"The detailed overall survival (OS), and disease-free survival (DFS) data onp16 INK4A orp14 ARF gene promoter methylation as a prognostic factor for RCC were insufficient."
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"Association ofp16 INK4A andp14 ARF methylation and tumor histology in cancer."
28969078
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"Therefore, we conducted this study of all available articles to further evaluate the effects ofp16 INK4A andp14 ARF promoter methylation in RCC."
28969078
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"The prognostic data involving the pooled hazard ratio (HR) were insufficient and not available, as only three studies reporting showed thatp16 INK4A andp14 ARF gene promoter methylation were not significantly correlated with the prognosis of RCC in OS or DFS [ xref , xref , xref ]."
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"The results suggested thatp16 INK4A andp14 ARF promoter methylation may be correlated with the carcinogenesis of RCC, and that methylatedp14 ARF , especially, can be a major susceptibility gene."
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