IndraLab

Statements

X leads to the methylation of CDKN2A. 4 / 4
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"The HBx can induce p16 gene promoter methylation and inhibit the expression of p16 in HepG2 cells."
36482819
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"Moreover, HBx induces hypermethylation of p16 (INK4A) promoter through DNMT1 and DNMT3A."
20620135
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"HBx induced DNA hypermethylation of p16 (INK4a) promoter to repress its expression, which subsequently led to activation of G1-CDKs, phosphorylation of pRb, activation of E2F1, and finally transcriptional activation of DNMT1."
17575144
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"DNMT1 and DNMT3A may play important roles in the process of HBx inducing hypermethylation of the p16 (INK4A) promoter in the early stages of HBV associated HCC."
19732323