IndraLab

Statements

All-trans-retinoic acid leads to the methylation of CDKN2A. 6 / 6
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"Consistently, ATRA downregulated levels of DNMT 1 and 3b, induced promoter hypomethylation of p16, facilitated recruitment of Ets1/2 transcriptional activators to the p16 promoter, and enhanced the p1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, we conclude that ATRA induces p14 promoter hypomethylation to trigger apoptosis."
25827071
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"Here, we show that ATRA induces promoter hypomethylation of p16 and p21 via down-regulation of DNA methyltransferases 1, 3a, and 3b to facilitate binding of Ets1/2 to the p16 promoter and p53 to the p21 promoter, resulting in up-regulation of their expression and subsequent induction of cellular senescence in HepG2 cells."
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"Combination treatment of ATRA and DAC induced DNA hypomethylation as well as gene expression of p16 and RARbeta, which contributed to the growth inhibition, differentiation, apoptosis and cell cycle arrest of U937 cells."
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"In addition, ATRA downregulated levels of DNMT1 and induced promoter hypomethylation of p16 and RAR-beta 2, resulting in activation of their expression in the control cells."
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"Consistently, ATRA downregulated levels of DNMT1 and 3b and induced promoter hypomethylation of p16 and RAR-beta 2, resulting in activation of their expression in the HepG2 cells without Core expressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23474497